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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7UC2

Structure of G6PD-D200N tetramer bound to NADP+ with no symmetry applied

Functional Information from GO Data
ChainGOidnamespacecontents
A0004345molecular_functionglucose-6-phosphate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005536molecular_functionD-glucose binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006098biological_processpentose-phosphate shunt
A0006629biological_processlipid metabolic process
A0006695biological_processcholesterol biosynthetic process
A0006739biological_processNADP+ metabolic process
A0006740biological_processNADPH regeneration
A0006749biological_processglutathione metabolic process
A0009051biological_processpentose-phosphate shunt, oxidative branch
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010041biological_processresponse to iron(III) ion
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
A0019322biological_processpentose biosynthetic process
A0021762biological_processsubstantia nigra development
A0030246molecular_functioncarbohydrate binding
A0032094biological_processresponse to food
A0034451cellular_componentcentriolar satellite
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043249biological_processerythrocyte maturation
A0043523biological_processregulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046390biological_processribose phosphate biosynthetic process
A0050661molecular_functionNADP binding
A0051156biological_processglucose 6-phosphate metabolic process
A0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
A0070062cellular_componentextracellular exosome
A1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0004345molecular_functionglucose-6-phosphate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005536molecular_functionD-glucose binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006098biological_processpentose-phosphate shunt
B0006629biological_processlipid metabolic process
B0006695biological_processcholesterol biosynthetic process
B0006739biological_processNADP+ metabolic process
B0006740biological_processNADPH regeneration
B0006749biological_processglutathione metabolic process
B0009051biological_processpentose-phosphate shunt, oxidative branch
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010041biological_processresponse to iron(III) ion
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
B0019322biological_processpentose biosynthetic process
B0021762biological_processsubstantia nigra development
B0030246molecular_functioncarbohydrate binding
B0032094biological_processresponse to food
B0034451cellular_componentcentriolar satellite
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043249biological_processerythrocyte maturation
B0043523biological_processregulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046390biological_processribose phosphate biosynthetic process
B0050661molecular_functionNADP binding
B0051156biological_processglucose 6-phosphate metabolic process
B0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
B0070062cellular_componentextracellular exosome
B1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
C0004345molecular_functionglucose-6-phosphate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005536molecular_functionD-glucose binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006098biological_processpentose-phosphate shunt
C0006629biological_processlipid metabolic process
C0006695biological_processcholesterol biosynthetic process
C0006739biological_processNADP+ metabolic process
C0006740biological_processNADPH regeneration
C0006749biological_processglutathione metabolic process
C0009051biological_processpentose-phosphate shunt, oxidative branch
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010041biological_processresponse to iron(III) ion
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
C0019322biological_processpentose biosynthetic process
C0021762biological_processsubstantia nigra development
C0030246molecular_functioncarbohydrate binding
C0032094biological_processresponse to food
C0034451cellular_componentcentriolar satellite
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043249biological_processerythrocyte maturation
C0043523biological_processregulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046390biological_processribose phosphate biosynthetic process
C0050661molecular_functionNADP binding
C0051156biological_processglucose 6-phosphate metabolic process
C0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
C0070062cellular_componentextracellular exosome
C1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
D0004345molecular_functionglucose-6-phosphate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005536molecular_functionD-glucose binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006006biological_processglucose metabolic process
D0006098biological_processpentose-phosphate shunt
D0006629biological_processlipid metabolic process
D0006695biological_processcholesterol biosynthetic process
D0006739biological_processNADP+ metabolic process
D0006740biological_processNADPH regeneration
D0006749biological_processglutathione metabolic process
D0009051biological_processpentose-phosphate shunt, oxidative branch
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010041biological_processresponse to iron(III) ion
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
D0019322biological_processpentose biosynthetic process
D0021762biological_processsubstantia nigra development
D0030246molecular_functioncarbohydrate binding
D0032094biological_processresponse to food
D0034451cellular_componentcentriolar satellite
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043249biological_processerythrocyte maturation
D0043523biological_processregulation of neuron apoptotic process
D0045471biological_processresponse to ethanol
D0046390biological_processribose phosphate biosynthetic process
D0050661molecular_functionNADP binding
D0051156biological_processglucose 6-phosphate metabolic process
D0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
D0070062cellular_componentextracellular exosome
D1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
D2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P11411","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10745013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BHL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24769394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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