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7UC2

Structure of G6PD-D200N tetramer bound to NADP+ with no symmetry applied

Functional Information from GO Data
ChainGOidnamespacecontents
A0004345molecular_functionglucose-6-phosphate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005536molecular_functionD-glucose binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006098biological_processpentose-phosphate shunt
A0006629biological_processlipid metabolic process
A0006695biological_processcholesterol biosynthetic process
A0006739biological_processNADP metabolic process
A0006740biological_processNADPH regeneration
A0006749biological_processglutathione metabolic process
A0009051biological_processpentose-phosphate shunt, oxidative branch
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010041biological_processresponse to iron(III) ion
A0010734biological_processnegative regulation of protein glutathionylation
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
A0019322biological_processpentose biosynthetic process
A0021762biological_processsubstantia nigra development
A0030246molecular_functioncarbohydrate binding
A0032094biological_processresponse to food
A0034451cellular_componentcentriolar satellite
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043231cellular_componentintracellular membrane-bounded organelle
A0043249biological_processerythrocyte maturation
A0043523biological_processregulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046390biological_processribose phosphate biosynthetic process
A0050661molecular_functionNADP binding
A0051156biological_processglucose 6-phosphate metabolic process
A0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
A0070062cellular_componentextracellular exosome
A1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0004345molecular_functionglucose-6-phosphate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005536molecular_functionD-glucose binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006098biological_processpentose-phosphate shunt
B0006629biological_processlipid metabolic process
B0006695biological_processcholesterol biosynthetic process
B0006739biological_processNADP metabolic process
B0006740biological_processNADPH regeneration
B0006749biological_processglutathione metabolic process
B0009051biological_processpentose-phosphate shunt, oxidative branch
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010041biological_processresponse to iron(III) ion
B0010734biological_processnegative regulation of protein glutathionylation
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
B0019322biological_processpentose biosynthetic process
B0021762biological_processsubstantia nigra development
B0030246molecular_functioncarbohydrate binding
B0032094biological_processresponse to food
B0034451cellular_componentcentriolar satellite
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043231cellular_componentintracellular membrane-bounded organelle
B0043249biological_processerythrocyte maturation
B0043523biological_processregulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046390biological_processribose phosphate biosynthetic process
B0050661molecular_functionNADP binding
B0051156biological_processglucose 6-phosphate metabolic process
B0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
B0070062cellular_componentextracellular exosome
B1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
C0004345molecular_functionglucose-6-phosphate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005536molecular_functionD-glucose binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006098biological_processpentose-phosphate shunt
C0006629biological_processlipid metabolic process
C0006695biological_processcholesterol biosynthetic process
C0006739biological_processNADP metabolic process
C0006740biological_processNADPH regeneration
C0006749biological_processglutathione metabolic process
C0009051biological_processpentose-phosphate shunt, oxidative branch
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010041biological_processresponse to iron(III) ion
C0010734biological_processnegative regulation of protein glutathionylation
C0014070biological_processresponse to organic cyclic compound
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
C0019322biological_processpentose biosynthetic process
C0021762biological_processsubstantia nigra development
C0030246molecular_functioncarbohydrate binding
C0032094biological_processresponse to food
C0034451cellular_componentcentriolar satellite
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043231cellular_componentintracellular membrane-bounded organelle
C0043249biological_processerythrocyte maturation
C0043523biological_processregulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046390biological_processribose phosphate biosynthetic process
C0050661molecular_functionNADP binding
C0051156biological_processglucose 6-phosphate metabolic process
C0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
C0070062cellular_componentextracellular exosome
C1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
C2000378biological_processnegative regulation of reactive oxygen species metabolic process
D0004345molecular_functionglucose-6-phosphate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005536molecular_functionD-glucose binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006006biological_processglucose metabolic process
D0006098biological_processpentose-phosphate shunt
D0006629biological_processlipid metabolic process
D0006695biological_processcholesterol biosynthetic process
D0006739biological_processNADP metabolic process
D0006740biological_processNADPH regeneration
D0006749biological_processglutathione metabolic process
D0009051biological_processpentose-phosphate shunt, oxidative branch
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010041biological_processresponse to iron(III) ion
D0010734biological_processnegative regulation of protein glutathionylation
D0014070biological_processresponse to organic cyclic compound
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
D0019322biological_processpentose biosynthetic process
D0021762biological_processsubstantia nigra development
D0030246molecular_functioncarbohydrate binding
D0032094biological_processresponse to food
D0034451cellular_componentcentriolar satellite
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043231cellular_componentintracellular membrane-bounded organelle
D0043249biological_processerythrocyte maturation
D0043523biological_processregulation of neuron apoptotic process
D0045471biological_processresponse to ethanol
D0046390biological_processribose phosphate biosynthetic process
D0050661molecular_functionNADP binding
D0051156biological_processglucose 6-phosphate metabolic process
D0061052biological_processnegative regulation of cell growth involved in cardiac muscle cell development
D0070062cellular_componentextracellular exosome
D1904879biological_processpositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
D2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P11411
ChainResidueDetails
AHIS263
BHIS263
CHIS263
DHIS263

site_idSWS_FT_FI2
Number of Residues52
DetailsBINDING: BINDING => ECO:0000269|PubMed:10745013, ECO:0000269|PubMed:15858258, ECO:0007744|PDB:1QKI, ECO:0007744|PDB:2BH9
ChainResidueDetails
AGLY38
AASP421
AARG487
ATYR503
ATRP509
BGLY38
BARG72
BTYR147
BLYS171
BARG357
BLYS366
AARG72
BARG370
BARG393
BTYR401
BASP421
BARG487
BTYR503
BTRP509
CGLY38
CARG72
CTYR147
ATYR147
CLYS171
CARG357
CLYS366
CARG370
CARG393
CTYR401
CASP421
CARG487
CTYR503
CTRP509
ALYS171
DGLY38
DARG72
DTYR147
DLYS171
DARG357
DLYS366
DARG370
DARG393
DTYR401
DASP421
AARG357
DARG487
DTYR503
DTRP509
ALYS366
AARG370
AARG393
ATYR401

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BH9
ChainResidueDetails
AHIS201
DHIS201
DGLU239
DASP258
AGLU239
AASP258
BHIS201
BGLU239
BASP258
CHIS201
CGLU239
CASP258

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15858258, ECO:0007744|PDB:2BHL
ChainResidueDetails
ALYS360
DLYS360
DARG365
DGLN395
AARG365
AGLN395
BLYS360
BARG365
BGLN395
CLYS360
CARG365
CGLN395

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7857286, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER8
BSER8
CSER8
DSER8

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR10
BTHR10
CTHR10
DTHR10

site_idSWS_FT_FI8
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS89
DLYS89
DLYS432
DLYS497
ALYS432
ALYS497
BLYS89
BLYS432
BLYS497
CLYS89
CLYS432
CLYS497

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS171
BLYS171
CLYS171
DLYS171

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:24769394, ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS403
BLYS403
CLYS403
DLYS403

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR503
BTYR503
CTYR503
DTYR503

227344

PDB entries from 2024-11-13

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