7UAI
Meprin alpha helix in complex with fetuin-B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005615 | cellular_component | extracellular space |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016020 | cellular_component | membrane |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016020 | cellular_component | membrane |
| D | 0004222 | molecular_function | metalloendopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016020 | cellular_component | membrane |
| E | 0004222 | molecular_function | metalloendopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0016020 | cellular_component | membrane |
| H | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| H | 0005615 | cellular_component | extracellular space |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. IIEHEILHAL |
| Chain | Residue | Details |
| E | ILE152-LEU161 |
| site_id | PS00740 |
| Number of Residues | 41 |
| Details | MAM_1 MAM domain signature. GyFMqfsTssgsaeeaal.LesriLypkrkqqCLqFfYkmtG |
| Chain | Residue | Details |
| E | GLY312-GLY352 |
| site_id | PS01254 |
| Number of Residues | 119 |
| Details | FETUIN_1 Fetuin family signature 1. CNDsdvlavagfalrdinkdrkdgyvlrlnrvndaqeyrrgglgslfyltldvletdCHvlrkkawqdCgmriffesvygq..CkaifymnnpsrvlylaaynCtlrpvskkkiymtCpdC |
| Chain | Residue | Details |
| A | CYS36-CYS154 |
| site_id | PS01255 |
| Number of Residues | 10 |
| Details | FETUIN_2 Fetuin family signature 2. DvLETdCHvL |
| Chain | Residue | Details |
| A | ASP87-LEU96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER315 | |
| H | SER315 | |
| C | GLU156 | |
| D | GLU156 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN37 | |
| D | HIS155 | |
| D | HIS159 | |
| D | HIS165 | |
| A | ASN136 | |
| H | ASN37 | |
| H | ASN136 | |
| B | HIS159 | |
| B | HIS165 | |
| C | HIS155 | |
| C | HIS159 | |
| C | HIS165 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN182 | |
| B | ASN258 | |
| B | ASN414 | |
| B | ASN440 | |
| B | ASN447 | |
| B | ASN539 | |
| C | ASN140 | |
| C | ASN222 | |
| C | ASN258 | |
| C | ASN414 | |
| C | ASN440 | |
| H | ASN182 | |
| C | ASN447 | |
| C | ASN539 | |
| D | ASN140 | |
| D | ASN222 | |
| D | ASN258 | |
| D | ASN414 | |
| D | ASN440 | |
| D | ASN447 | |
| D | ASN539 | |
| E | ASN258 | |
| E | ASN414 | |
| E | ASN440 | |
| E | ASN447 | |
| E | ASN539 | |
| B | ASN140 | |
| B | ASN222 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250|UniProtKB:Q58D62 |
| Chain | Residue | Details |
| A | THR289 | |
| A | THR292 | |
| H | THR289 | |
| H | THR292 |
