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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7TV4

Crystal structure of NEMO CoZi in complex with HOIP NZF1 and linear diubiquitin

Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
CLYS27-ASP52
CLYS103-ASP128
site_idPS01358
Number of Residues20
DetailsZF_RANBP2_1 Zinc finger RanBP2-type signature. WaCqs..CtfeNeaaavlCsiC
ChainResidueDetails
KTRP354-CYS373
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21455181","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin and interchain with MARCHF2)","evidences":[{"source":"PubMed","id":"21455181","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32935379","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"14651848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21455181","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"15620648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17562858","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19136968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21455181","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"14651848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19136968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20010814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21455181","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"20010814","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"O88522","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues75
DetailsDomain: {"description":"Ubiquitin-like 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-02-11

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