7SQ2
Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex
Replaces: 3OHMFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001501 | biological_process | skeletal system development |
| A | 0001508 | biological_process | action potential |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005834 | cellular_component | heterotrimeric G-protein complex |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007207 | biological_process | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| A | 0007215 | biological_process | glutamate receptor signaling pathway |
| A | 0007507 | biological_process | heart development |
| A | 0008217 | biological_process | regulation of blood pressure |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0010543 | biological_process | regulation of platelet activation |
| A | 0016020 | cellular_component | membrane |
| A | 0016322 | biological_process | neuron remodeling |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0021884 | biological_process | forebrain neuron development |
| A | 0030234 | molecular_function | enzyme regulator activity |
| A | 0030425 | cellular_component | dendrite |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0042711 | biological_process | maternal behavior |
| A | 0042733 | biological_process | embryonic digit morphogenesis |
| A | 0044297 | cellular_component | cell body |
| A | 0045634 | biological_process | regulation of melanocyte differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| A | 0048066 | biological_process | developmental pigmentation |
| A | 0060158 | biological_process | phospholipase C-activating dopamine receptor signaling pathway |
| A | 0086100 | biological_process | endothelin receptor signaling pathway |
| A | 0099524 | cellular_component | postsynaptic cytosol |
| A | 1904888 | biological_process | cranial skeletal system development |
| A | 1990806 | biological_process | ligand-gated ion channel signaling pathway |
| B | 0004435 | molecular_function | phosphatidylinositol-4,5-bisphosphate phospholipase C activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20966218","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SQ2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"5-glutamyl histamine","evidences":[{"source":"PubMed","id":"23022564","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 150 |
| Details | Domain: {"description":"PI-PLC X-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 116 |
| Details | Domain: {"description":"PI-PLC Y-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00271","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 128 |
| Details | Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
