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7SOX

Cryo-electron tomography structure of membrane-bound EHD4 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006907biological_processpinocytosis
A0030100biological_processregulation of endocytosis
A0031901cellular_componentearly endosome membrane
A0032456biological_processendocytic recycling
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0051260biological_processprotein homooligomerization
A0055038cellular_componentrecycling endosome membrane
A0071363biological_processcellular response to growth factor stimulus
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006907biological_processpinocytosis
B0030100biological_processregulation of endocytosis
B0031901cellular_componentearly endosome membrane
B0032456biological_processendocytic recycling
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0051260biological_processprotein homooligomerization
B0055038cellular_componentrecycling endosome membrane
B0071363biological_processcellular response to growth factor stimulus
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006907biological_processpinocytosis
C0030100biological_processregulation of endocytosis
C0031901cellular_componentearly endosome membrane
C0032456biological_processendocytic recycling
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0051260biological_processprotein homooligomerization
C0055038cellular_componentrecycling endosome membrane
C0071363biological_processcellular response to growth factor stimulus
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006907biological_processpinocytosis
D0030100biological_processregulation of endocytosis
D0031901cellular_componentearly endosome membrane
D0032456biological_processendocytic recycling
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0051260biological_processprotein homooligomerization
D0055038cellular_componentrecycling endosome membrane
D0071363biological_processcellular response to growth factor stimulus
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005783cellular_componentendoplasmic reticulum
E0005886cellular_componentplasma membrane
E0006907biological_processpinocytosis
E0030100biological_processregulation of endocytosis
E0031901cellular_componentearly endosome membrane
E0032456biological_processendocytic recycling
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0051260biological_processprotein homooligomerization
E0055038cellular_componentrecycling endosome membrane
E0071363biological_processcellular response to growth factor stimulus
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005783cellular_componentendoplasmic reticulum
F0005886cellular_componentplasma membrane
F0006907biological_processpinocytosis
F0030100biological_processregulation of endocytosis
F0031901cellular_componentearly endosome membrane
F0032456biological_processendocytic recycling
F0046872molecular_functionmetal ion binding
F0048471cellular_componentperinuclear region of cytoplasm
F0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
F0051260biological_processprotein homooligomerization
F0055038cellular_componentrecycling endosome membrane
F0071363biological_processcellular response to growth factor stimulus
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005525molecular_functionGTP binding
G0005737cellular_componentcytoplasm
G0005768cellular_componentendosome
G0005783cellular_componentendoplasmic reticulum
G0005886cellular_componentplasma membrane
G0006907biological_processpinocytosis
G0030100biological_processregulation of endocytosis
G0031901cellular_componentearly endosome membrane
G0032456biological_processendocytic recycling
G0046872molecular_functionmetal ion binding
G0048471cellular_componentperinuclear region of cytoplasm
G0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
G0051260biological_processprotein homooligomerization
G0055038cellular_componentrecycling endosome membrane
G0071363biological_processcellular response to growth factor stimulus
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005525molecular_functionGTP binding
H0005737cellular_componentcytoplasm
H0005768cellular_componentendosome
H0005783cellular_componentendoplasmic reticulum
H0005886cellular_componentplasma membrane
H0006907biological_processpinocytosis
H0030100biological_processregulation of endocytosis
H0031901cellular_componentearly endosome membrane
H0032456biological_processendocytic recycling
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
H0051260biological_processprotein homooligomerization
H0055038cellular_componentrecycling endosome membrane
H0071363biological_processcellular response to growth factor stimulus
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005525molecular_functionGTP binding
I0005737cellular_componentcytoplasm
I0005768cellular_componentendosome
I0005783cellular_componentendoplasmic reticulum
I0005886cellular_componentplasma membrane
I0006907biological_processpinocytosis
I0030100biological_processregulation of endocytosis
I0031901cellular_componentearly endosome membrane
I0032456biological_processendocytic recycling
I0046872molecular_functionmetal ion binding
I0048471cellular_componentperinuclear region of cytoplasm
I0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
I0051260biological_processprotein homooligomerization
I0055038cellular_componentrecycling endosome membrane
I0071363biological_processcellular response to growth factor stimulus
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005525molecular_functionGTP binding
J0005737cellular_componentcytoplasm
J0005768cellular_componentendosome
J0005783cellular_componentendoplasmic reticulum
J0005886cellular_componentplasma membrane
J0006907biological_processpinocytosis
J0030100biological_processregulation of endocytosis
J0031901cellular_componentearly endosome membrane
J0032456biological_processendocytic recycling
J0046872molecular_functionmetal ion binding
J0048471cellular_componentperinuclear region of cytoplasm
J0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
J0051260biological_processprotein homooligomerization
J0055038cellular_componentrecycling endosome membrane
J0071363biological_processcellular response to growth factor stimulus
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005525molecular_functionGTP binding
K0005737cellular_componentcytoplasm
K0005768cellular_componentendosome
K0005783cellular_componentendoplasmic reticulum
K0005886cellular_componentplasma membrane
K0006907biological_processpinocytosis
K0030100biological_processregulation of endocytosis
K0031901cellular_componentearly endosome membrane
K0032456biological_processendocytic recycling
K0046872molecular_functionmetal ion binding
K0048471cellular_componentperinuclear region of cytoplasm
K0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
K0051260biological_processprotein homooligomerization
K0055038cellular_componentrecycling endosome membrane
K0071363biological_processcellular response to growth factor stimulus
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005525molecular_functionGTP binding
L0005737cellular_componentcytoplasm
L0005768cellular_componentendosome
L0005783cellular_componentendoplasmic reticulum
L0005886cellular_componentplasma membrane
L0006907biological_processpinocytosis
L0030100biological_processregulation of endocytosis
L0031901cellular_componentearly endosome membrane
L0032456biological_processendocytic recycling
L0046872molecular_functionmetal ion binding
L0048471cellular_componentperinuclear region of cytoplasm
L0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
L0051260biological_processprotein homooligomerization
L0055038cellular_componentrecycling endosome membrane
L0071363biological_processcellular response to growth factor stimulus
M0005509molecular_functioncalcium ion binding
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005525molecular_functionGTP binding
M0005737cellular_componentcytoplasm
M0005768cellular_componentendosome
M0005783cellular_componentendoplasmic reticulum
M0005886cellular_componentplasma membrane
M0006907biological_processpinocytosis
M0030100biological_processregulation of endocytosis
M0031901cellular_componentearly endosome membrane
M0032456biological_processendocytic recycling
M0046872molecular_functionmetal ion binding
M0048471cellular_componentperinuclear region of cytoplasm
M0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
M0051260biological_processprotein homooligomerization
M0055038cellular_componentrecycling endosome membrane
M0071363biological_processcellular response to growth factor stimulus
N0005509molecular_functioncalcium ion binding
N0005515molecular_functionprotein binding
N0005524molecular_functionATP binding
N0005525molecular_functionGTP binding
N0005737cellular_componentcytoplasm
N0005768cellular_componentendosome
N0005783cellular_componentendoplasmic reticulum
N0005886cellular_componentplasma membrane
N0006907biological_processpinocytosis
N0030100biological_processregulation of endocytosis
N0031901cellular_componentearly endosome membrane
N0032456biological_processendocytic recycling
N0046872molecular_functionmetal ion binding
N0048471cellular_componentperinuclear region of cytoplasm
N0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
N0051260biological_processprotein homooligomerization
N0055038cellular_componentrecycling endosome membrane
N0071363biological_processcellular response to growth factor stimulus
O0005509molecular_functioncalcium ion binding
O0005515molecular_functionprotein binding
O0005524molecular_functionATP binding
O0005525molecular_functionGTP binding
O0005737cellular_componentcytoplasm
O0005768cellular_componentendosome
O0005783cellular_componentendoplasmic reticulum
O0005886cellular_componentplasma membrane
O0006907biological_processpinocytosis
O0030100biological_processregulation of endocytosis
O0031901cellular_componentearly endosome membrane
O0032456biological_processendocytic recycling
O0046872molecular_functionmetal ion binding
O0048471cellular_componentperinuclear region of cytoplasm
O0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
O0051260biological_processprotein homooligomerization
O0055038cellular_componentrecycling endosome membrane
O0071363biological_processcellular response to growth factor stimulus
P0005509molecular_functioncalcium ion binding
P0005515molecular_functionprotein binding
P0005524molecular_functionATP binding
P0005525molecular_functionGTP binding
P0005737cellular_componentcytoplasm
P0005768cellular_componentendosome
P0005783cellular_componentendoplasmic reticulum
P0005886cellular_componentplasma membrane
P0006907biological_processpinocytosis
P0030100biological_processregulation of endocytosis
P0031901cellular_componentearly endosome membrane
P0032456biological_processendocytic recycling
P0046872molecular_functionmetal ion binding
P0048471cellular_componentperinuclear region of cytoplasm
P0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
P0051260biological_processprotein homooligomerization
P0055038cellular_componentrecycling endosome membrane
P0071363biological_processcellular response to growth factor stimulus
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DCDCDGMLDeeEF
ChainResidueDetails
AASP492-PHE504

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8BH64
ChainResidueDetails
AGLY68
DGLY68
DLYS223
DTRP261
EGLY68
ELYS223
ETRP261
FGLY68
FLYS223
FTRP261
GGLY68
ALYS223
GLYS223
GTRP261
HGLY68
HLYS223
HTRP261
IGLY68
ILYS223
ITRP261
JGLY68
JLYS223
ATRP261
JTRP261
KGLY68
KLYS223
KTRP261
LGLY68
LLYS223
LTRP261
MGLY68
MLYS223
MTRP261
BGLY68
NGLY68
NLYS223
NTRP261
OGLY68
OLYS223
OTRP261
PGLY68
PLYS223
PTRP261
BLYS223
BTRP261
CGLY68
CLYS223
CTRP261

site_idSWS_FT_FI2
Number of Residues80
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP492
BGLU503
CASP492
CASP494
CASP496
CMET498
CGLU503
DASP492
DASP494
DASP496
DMET498
AASP494
DGLU503
EASP492
EASP494
EASP496
EMET498
EGLU503
FASP492
FASP494
FASP496
FMET498
AASP496
FGLU503
GASP492
GASP494
GASP496
GMET498
GGLU503
HASP492
HASP494
HASP496
HMET498
AMET498
HGLU503
IASP492
IASP494
IASP496
IMET498
IGLU503
JASP492
JASP494
JASP496
JMET498
AGLU503
JGLU503
KASP492
KASP494
KASP496
KMET498
KGLU503
LASP492
LASP494
LASP496
LMET498
BASP492
LGLU503
MASP492
MASP494
MASP496
MMET498
MGLU503
NASP492
NASP494
NASP496
NMET498
BASP494
NGLU503
OASP492
OASP494
OASP496
OMET498
OGLU503
PASP492
PASP494
PASP496
PMET498
BASP496
PGLU503
BMET498

site_idSWS_FT_FI3
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9H223
ChainResidueDetails
ASER162
JSER162
KSER162
LSER162
MSER162
NSER162
OSER162
PSER162
BSER162
CSER162
DSER162
ESER162
FSER162
GSER162
HSER162
ISER162

site_idSWS_FT_FI4
Number of Residues16
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9H223
ChainResidueDetails
ATYR451
JTYR451
KTYR451
LTYR451
MTYR451
NTYR451
OTYR451
PTYR451
BTYR451
CTYR451
DTYR451
ETYR451
FTYR451
GTYR451
HTYR451
ITYR451

site_idSWS_FT_FI5
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER459
JSER459
KSER459
LSER459
MSER459
NSER459
OSER459
PSER459
BSER459
CSER459
DSER459
ESER459
FSER459
GSER459
HSER459
ISER459

225946

PDB entries from 2024-10-09

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