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7SOX

Cryo-electron tomography structure of membrane-bound EHD4 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002042biological_processcell migration involved in sprouting angiogenesis
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005769cellular_componentearly endosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006897biological_processendocytosis
A0006907biological_processpinocytosis
A0030100biological_processregulation of endocytosis
A0030139cellular_componentendocytic vesicle
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031901cellular_componentearly endosome membrane
A0032456biological_processendocytic recycling
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0051260biological_processprotein homooligomerization
A0055038cellular_componentrecycling endosome membrane
A0060271biological_processcilium assembly
A0071363biological_processcellular response to growth factor stimulus
A0072659biological_processprotein localization to plasma membrane
B0000166molecular_functionnucleotide binding
B0002042biological_processcell migration involved in sprouting angiogenesis
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005769cellular_componentearly endosome
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0006897biological_processendocytosis
B0006907biological_processpinocytosis
B0030100biological_processregulation of endocytosis
B0030139cellular_componentendocytic vesicle
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031901cellular_componentearly endosome membrane
B0032456biological_processendocytic recycling
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0051260biological_processprotein homooligomerization
B0055038cellular_componentrecycling endosome membrane
B0060271biological_processcilium assembly
B0071363biological_processcellular response to growth factor stimulus
B0072659biological_processprotein localization to plasma membrane
C0000166molecular_functionnucleotide binding
C0002042biological_processcell migration involved in sprouting angiogenesis
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005769cellular_componentearly endosome
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0005912cellular_componentadherens junction
C0006897biological_processendocytosis
C0006907biological_processpinocytosis
C0030100biological_processregulation of endocytosis
C0030139cellular_componentendocytic vesicle
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031901cellular_componentearly endosome membrane
C0032456biological_processendocytic recycling
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0051260biological_processprotein homooligomerization
C0055038cellular_componentrecycling endosome membrane
C0060271biological_processcilium assembly
C0071363biological_processcellular response to growth factor stimulus
C0072659biological_processprotein localization to plasma membrane
D0000166molecular_functionnucleotide binding
D0002042biological_processcell migration involved in sprouting angiogenesis
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005769cellular_componentearly endosome
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0006897biological_processendocytosis
D0006907biological_processpinocytosis
D0030100biological_processregulation of endocytosis
D0030139cellular_componentendocytic vesicle
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031901cellular_componentearly endosome membrane
D0032456biological_processendocytic recycling
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0051260biological_processprotein homooligomerization
D0055038cellular_componentrecycling endosome membrane
D0060271biological_processcilium assembly
D0071363biological_processcellular response to growth factor stimulus
D0072659biological_processprotein localization to plasma membrane
E0000166molecular_functionnucleotide binding
E0002042biological_processcell migration involved in sprouting angiogenesis
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005769cellular_componentearly endosome
E0005783cellular_componentendoplasmic reticulum
E0005886cellular_componentplasma membrane
E0005912cellular_componentadherens junction
E0006897biological_processendocytosis
E0006907biological_processpinocytosis
E0030100biological_processregulation of endocytosis
E0030139cellular_componentendocytic vesicle
E0030674molecular_functionprotein-macromolecule adaptor activity
E0031901cellular_componentearly endosome membrane
E0032456biological_processendocytic recycling
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0051260biological_processprotein homooligomerization
E0055038cellular_componentrecycling endosome membrane
E0060271biological_processcilium assembly
E0071363biological_processcellular response to growth factor stimulus
E0072659biological_processprotein localization to plasma membrane
F0000166molecular_functionnucleotide binding
F0002042biological_processcell migration involved in sprouting angiogenesis
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005769cellular_componentearly endosome
F0005783cellular_componentendoplasmic reticulum
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0006897biological_processendocytosis
F0006907biological_processpinocytosis
F0030100biological_processregulation of endocytosis
F0030139cellular_componentendocytic vesicle
F0030674molecular_functionprotein-macromolecule adaptor activity
F0031901cellular_componentearly endosome membrane
F0032456biological_processendocytic recycling
F0046872molecular_functionmetal ion binding
F0048471cellular_componentperinuclear region of cytoplasm
F0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
F0051260biological_processprotein homooligomerization
F0055038cellular_componentrecycling endosome membrane
F0060271biological_processcilium assembly
F0071363biological_processcellular response to growth factor stimulus
F0072659biological_processprotein localization to plasma membrane
G0000166molecular_functionnucleotide binding
G0002042biological_processcell migration involved in sprouting angiogenesis
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005525molecular_functionGTP binding
G0005737cellular_componentcytoplasm
G0005769cellular_componentearly endosome
G0005783cellular_componentendoplasmic reticulum
G0005886cellular_componentplasma membrane
G0005912cellular_componentadherens junction
G0006897biological_processendocytosis
G0006907biological_processpinocytosis
G0030100biological_processregulation of endocytosis
G0030139cellular_componentendocytic vesicle
G0030674molecular_functionprotein-macromolecule adaptor activity
G0031901cellular_componentearly endosome membrane
G0032456biological_processendocytic recycling
G0046872molecular_functionmetal ion binding
G0048471cellular_componentperinuclear region of cytoplasm
G0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
G0051260biological_processprotein homooligomerization
G0055038cellular_componentrecycling endosome membrane
G0060271biological_processcilium assembly
G0071363biological_processcellular response to growth factor stimulus
G0072659biological_processprotein localization to plasma membrane
H0000166molecular_functionnucleotide binding
H0002042biological_processcell migration involved in sprouting angiogenesis
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005525molecular_functionGTP binding
H0005737cellular_componentcytoplasm
H0005769cellular_componentearly endosome
H0005783cellular_componentendoplasmic reticulum
H0005886cellular_componentplasma membrane
H0005912cellular_componentadherens junction
H0006897biological_processendocytosis
H0006907biological_processpinocytosis
H0030100biological_processregulation of endocytosis
H0030139cellular_componentendocytic vesicle
H0030674molecular_functionprotein-macromolecule adaptor activity
H0031901cellular_componentearly endosome membrane
H0032456biological_processendocytic recycling
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
H0051260biological_processprotein homooligomerization
H0055038cellular_componentrecycling endosome membrane
H0060271biological_processcilium assembly
H0071363biological_processcellular response to growth factor stimulus
H0072659biological_processprotein localization to plasma membrane
I0000166molecular_functionnucleotide binding
I0002042biological_processcell migration involved in sprouting angiogenesis
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005525molecular_functionGTP binding
I0005737cellular_componentcytoplasm
I0005769cellular_componentearly endosome
I0005783cellular_componentendoplasmic reticulum
I0005886cellular_componentplasma membrane
I0005912cellular_componentadherens junction
I0006897biological_processendocytosis
I0006907biological_processpinocytosis
I0030100biological_processregulation of endocytosis
I0030139cellular_componentendocytic vesicle
I0030674molecular_functionprotein-macromolecule adaptor activity
I0031901cellular_componentearly endosome membrane
I0032456biological_processendocytic recycling
I0046872molecular_functionmetal ion binding
I0048471cellular_componentperinuclear region of cytoplasm
I0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
I0051260biological_processprotein homooligomerization
I0055038cellular_componentrecycling endosome membrane
I0060271biological_processcilium assembly
I0071363biological_processcellular response to growth factor stimulus
I0072659biological_processprotein localization to plasma membrane
J0000166molecular_functionnucleotide binding
J0002042biological_processcell migration involved in sprouting angiogenesis
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005525molecular_functionGTP binding
J0005737cellular_componentcytoplasm
J0005769cellular_componentearly endosome
J0005783cellular_componentendoplasmic reticulum
J0005886cellular_componentplasma membrane
J0005912cellular_componentadherens junction
J0006897biological_processendocytosis
J0006907biological_processpinocytosis
J0030100biological_processregulation of endocytosis
J0030139cellular_componentendocytic vesicle
J0030674molecular_functionprotein-macromolecule adaptor activity
J0031901cellular_componentearly endosome membrane
J0032456biological_processendocytic recycling
J0046872molecular_functionmetal ion binding
J0048471cellular_componentperinuclear region of cytoplasm
J0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
J0051260biological_processprotein homooligomerization
J0055038cellular_componentrecycling endosome membrane
J0060271biological_processcilium assembly
J0071363biological_processcellular response to growth factor stimulus
J0072659biological_processprotein localization to plasma membrane
K0000166molecular_functionnucleotide binding
K0002042biological_processcell migration involved in sprouting angiogenesis
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005524molecular_functionATP binding
K0005525molecular_functionGTP binding
K0005737cellular_componentcytoplasm
K0005769cellular_componentearly endosome
K0005783cellular_componentendoplasmic reticulum
K0005886cellular_componentplasma membrane
K0005912cellular_componentadherens junction
K0006897biological_processendocytosis
K0006907biological_processpinocytosis
K0030100biological_processregulation of endocytosis
K0030139cellular_componentendocytic vesicle
K0030674molecular_functionprotein-macromolecule adaptor activity
K0031901cellular_componentearly endosome membrane
K0032456biological_processendocytic recycling
K0046872molecular_functionmetal ion binding
K0048471cellular_componentperinuclear region of cytoplasm
K0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
K0051260biological_processprotein homooligomerization
K0055038cellular_componentrecycling endosome membrane
K0060271biological_processcilium assembly
K0071363biological_processcellular response to growth factor stimulus
K0072659biological_processprotein localization to plasma membrane
L0000166molecular_functionnucleotide binding
L0002042biological_processcell migration involved in sprouting angiogenesis
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005525molecular_functionGTP binding
L0005737cellular_componentcytoplasm
L0005769cellular_componentearly endosome
L0005783cellular_componentendoplasmic reticulum
L0005886cellular_componentplasma membrane
L0005912cellular_componentadherens junction
L0006897biological_processendocytosis
L0006907biological_processpinocytosis
L0030100biological_processregulation of endocytosis
L0030139cellular_componentendocytic vesicle
L0030674molecular_functionprotein-macromolecule adaptor activity
L0031901cellular_componentearly endosome membrane
L0032456biological_processendocytic recycling
L0046872molecular_functionmetal ion binding
L0048471cellular_componentperinuclear region of cytoplasm
L0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
L0051260biological_processprotein homooligomerization
L0055038cellular_componentrecycling endosome membrane
L0060271biological_processcilium assembly
L0071363biological_processcellular response to growth factor stimulus
L0072659biological_processprotein localization to plasma membrane
M0000166molecular_functionnucleotide binding
M0002042biological_processcell migration involved in sprouting angiogenesis
M0005509molecular_functioncalcium ion binding
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005525molecular_functionGTP binding
M0005737cellular_componentcytoplasm
M0005769cellular_componentearly endosome
M0005783cellular_componentendoplasmic reticulum
M0005886cellular_componentplasma membrane
M0005912cellular_componentadherens junction
M0006897biological_processendocytosis
M0006907biological_processpinocytosis
M0030100biological_processregulation of endocytosis
M0030139cellular_componentendocytic vesicle
M0030674molecular_functionprotein-macromolecule adaptor activity
M0031901cellular_componentearly endosome membrane
M0032456biological_processendocytic recycling
M0046872molecular_functionmetal ion binding
M0048471cellular_componentperinuclear region of cytoplasm
M0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
M0051260biological_processprotein homooligomerization
M0055038cellular_componentrecycling endosome membrane
M0060271biological_processcilium assembly
M0071363biological_processcellular response to growth factor stimulus
M0072659biological_processprotein localization to plasma membrane
N0000166molecular_functionnucleotide binding
N0002042biological_processcell migration involved in sprouting angiogenesis
N0005509molecular_functioncalcium ion binding
N0005515molecular_functionprotein binding
N0005524molecular_functionATP binding
N0005525molecular_functionGTP binding
N0005737cellular_componentcytoplasm
N0005769cellular_componentearly endosome
N0005783cellular_componentendoplasmic reticulum
N0005886cellular_componentplasma membrane
N0005912cellular_componentadherens junction
N0006897biological_processendocytosis
N0006907biological_processpinocytosis
N0030100biological_processregulation of endocytosis
N0030139cellular_componentendocytic vesicle
N0030674molecular_functionprotein-macromolecule adaptor activity
N0031901cellular_componentearly endosome membrane
N0032456biological_processendocytic recycling
N0046872molecular_functionmetal ion binding
N0048471cellular_componentperinuclear region of cytoplasm
N0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
N0051260biological_processprotein homooligomerization
N0055038cellular_componentrecycling endosome membrane
N0060271biological_processcilium assembly
N0071363biological_processcellular response to growth factor stimulus
N0072659biological_processprotein localization to plasma membrane
O0000166molecular_functionnucleotide binding
O0002042biological_processcell migration involved in sprouting angiogenesis
O0005509molecular_functioncalcium ion binding
O0005515molecular_functionprotein binding
O0005524molecular_functionATP binding
O0005525molecular_functionGTP binding
O0005737cellular_componentcytoplasm
O0005769cellular_componentearly endosome
O0005783cellular_componentendoplasmic reticulum
O0005886cellular_componentplasma membrane
O0005912cellular_componentadherens junction
O0006897biological_processendocytosis
O0006907biological_processpinocytosis
O0030100biological_processregulation of endocytosis
O0030139cellular_componentendocytic vesicle
O0030674molecular_functionprotein-macromolecule adaptor activity
O0031901cellular_componentearly endosome membrane
O0032456biological_processendocytic recycling
O0046872molecular_functionmetal ion binding
O0048471cellular_componentperinuclear region of cytoplasm
O0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
O0051260biological_processprotein homooligomerization
O0055038cellular_componentrecycling endosome membrane
O0060271biological_processcilium assembly
O0071363biological_processcellular response to growth factor stimulus
O0072659biological_processprotein localization to plasma membrane
P0000166molecular_functionnucleotide binding
P0002042biological_processcell migration involved in sprouting angiogenesis
P0005509molecular_functioncalcium ion binding
P0005515molecular_functionprotein binding
P0005524molecular_functionATP binding
P0005525molecular_functionGTP binding
P0005737cellular_componentcytoplasm
P0005769cellular_componentearly endosome
P0005783cellular_componentendoplasmic reticulum
P0005886cellular_componentplasma membrane
P0005912cellular_componentadherens junction
P0006897biological_processendocytosis
P0006907biological_processpinocytosis
P0030100biological_processregulation of endocytosis
P0030139cellular_componentendocytic vesicle
P0030674molecular_functionprotein-macromolecule adaptor activity
P0031901cellular_componentearly endosome membrane
P0032456biological_processendocytic recycling
P0046872molecular_functionmetal ion binding
P0048471cellular_componentperinuclear region of cytoplasm
P0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
P0051260biological_processprotein homooligomerization
P0055038cellular_componentrecycling endosome membrane
P0060271biological_processcilium assembly
P0071363biological_processcellular response to growth factor stimulus
P0072659biological_processprotein localization to plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DCDCDGMLDeeEF
ChainResidueDetails
AASP492-PHE504

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3696
DetailsDomain: {"description":"Dynamin-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1408
DetailsDomain: {"description":"EH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00077","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues560
DetailsDomain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues112
DetailsRegion: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues16
DetailsRegion: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues48
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues48
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues16
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues144
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8BH64","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues80
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues16
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9H223","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues16
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9H223","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues16
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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