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7SO0

Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human Chemokine CCL2

Functional Information from GO Data
ChainGOidnamespacecontents
A0019957molecular_functionC-C chemokine binding
A1900137biological_processnegative regulation of chemokine activity
B0001525biological_processangiogenesis
B0002548biological_processmonocyte chemotaxis
B0004672molecular_functionprotein kinase activity
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006468biological_processprotein phosphorylation
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0006959biological_processhumoral immune response
B0007010biological_processcytoskeleton organization
B0007155biological_processcell adhesion
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007186biological_processG protein-coupled receptor signaling pathway
B0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008009molecular_functionchemokine activity
B0008360biological_processregulation of cell shape
B0009617biological_processresponse to bacterium
B0009887biological_processanimal organ morphogenesis
B0019079biological_processviral genome replication
B0019221biological_processcytokine-mediated signaling pathway
B0019233biological_processsensory perception of pain
B0019725biological_processcellular homeostasis
B0030335biological_processpositive regulation of cell migration
B0031727molecular_functionCCR2 chemokine receptor binding
B0034351biological_processnegative regulation of glial cell apoptotic process
B0035684biological_processhelper T cell extravasation
B0043524biological_processnegative regulation of neuron apoptotic process
B0043615biological_processastrocyte cell migration
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0048020molecular_functionCCR chemokine receptor binding
B0048245biological_processeosinophil chemotaxis
B0048246biological_processmacrophage chemotaxis
B0050870biological_processpositive regulation of T cell activation
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0051968biological_processpositive regulation of synaptic transmission, glutamatergic
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
B0071222biological_processcellular response to lipopolysaccharide
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0090280biological_processpositive regulation of calcium ion import
B1904783biological_processpositive regulation of NMDA glutamate receptor activity
B1905563biological_processnegative regulation of vascular endothelial cell proliferation
B2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
B2000353biological_processpositive regulation of endothelial cell apoptotic process
B2000427biological_processpositive regulation of apoptotic cell clearance
B2000502biological_processnegative regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues43
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCYnftnrk..IsvqrLasYrritssk.Cpke.AVIFktivakei.CA
ChainResidueDetails
BCYS11-ALA53

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsSITE: Involved in dimerization
ChainResidueDetails
BALA8
BLYS35
BLYS38

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Involved in dimerization, receptor binding and signaling
ChainResidueDetails
BTYR13

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Involved in GAG binding
ChainResidueDetails
BARG18
BLYS19
BLYS58
BHIS66

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Involved in GAG binding and receptor binding
ChainResidueDetails
BARG24
BLYS49

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:1661560, ECO:0000269|PubMed:2648385
ChainResidueDetails
BGLN1

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN14

226707

PDB entries from 2024-10-30

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