7SI4
CRYSTAL STRUCTURE OF EED WITH MRTX-2219
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001222 | molecular_function | transcription corepressor binding |
| A | 0001739 | cellular_component | sex chromatin |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005677 | cellular_component | chromatin silencing complex |
| A | 0005694 | cellular_component | chromosome |
| A | 0006325 | biological_process | chromatin organization |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0021510 | biological_process | spinal cord development |
| A | 0031491 | molecular_function | nucleosome binding |
| A | 0031507 | biological_process | heterochromatin formation |
| A | 0035098 | cellular_component | ESC/E(Z) complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045120 | cellular_component | pronucleus |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0140718 | biological_process | facultative heterochromatin formation |
| A | 1990841 | molecular_function | promoter-specific chromatin binding |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI |
| Chain | Residue | Details |
| A | LEU206-ILE220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 154 |
| Details | Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
