7S7C

Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000176	cellular_component	nuclear exosome (RNase complex)
A	0000178	cellular_component	exosome (RNase complex)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000460	biological_process	maturation of 5.8S rRNA
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0006397	biological_process	mRNA processing
A	0006401	biological_process	RNA catabolic process
A	0006974	biological_process	DNA damage response
A	0008380	biological_process	RNA splicing
A	0016076	biological_process	snRNA catabolic process
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031499	cellular_component	TRAMP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0008270	molecular_function	zinc ion binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
E	0000166	molecular_function	nucleotide binding
E	0000176	cellular_component	nuclear exosome (RNase complex)
E	0000178	cellular_component	exosome (RNase complex)
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0000460	biological_process	maturation of 5.8S rRNA
E	0003676	molecular_function	nucleic acid binding
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005730	cellular_component	nucleolus
E	0006364	biological_process	rRNA processing
E	0006397	biological_process	mRNA processing
E	0006401	biological_process	RNA catabolic process
E	0006974	biological_process	DNA damage response
E	0008380	biological_process	RNA splicing
E	0016076	biological_process	snRNA catabolic process
E	0016607	cellular_component	nuclear speck
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0031499	cellular_component	TRAMP complex
E	0071013	cellular_component	catalytic step 2 spliceosome
F	0003676	molecular_function	nucleic acid binding
F	0008270	molecular_function	zinc ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	172
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31358741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29844170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358741","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	28
Details	Region: {"description":"RBM7 binding","evidences":[{"source":"PubMed","id":"27905398","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LXY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	27
Details	Region: {"description":"ZCCHC8 binding","evidences":[{"source":"PubMed","id":"27905398","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LXY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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