7S7B
Human Nuclear exosome targeting (NEXT) complex homodimer bound to RNA (substrate 1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000176 | cellular_component | nuclear exosome (RNase complex) |
| A | 0000178 | cellular_component | exosome (RNase complex) |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0000460 | biological_process | maturation of 5.8S rRNA |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016076 | biological_process | snRNA catabolic process |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031499 | cellular_component | TRAMP complex |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003723 | molecular_function | RNA binding |
| E | 0000176 | cellular_component | nuclear exosome (RNase complex) |
| E | 0000178 | cellular_component | exosome (RNase complex) |
| E | 0000398 | biological_process | mRNA splicing, via spliceosome |
| E | 0000460 | biological_process | maturation of 5.8S rRNA |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0003723 | molecular_function | RNA binding |
| E | 0003724 | molecular_function | RNA helicase activity |
| E | 0004386 | molecular_function | helicase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005681 | cellular_component | spliceosomal complex |
| E | 0005730 | cellular_component | nucleolus |
| E | 0006364 | biological_process | rRNA processing |
| E | 0006397 | biological_process | mRNA processing |
| E | 0006401 | biological_process | RNA catabolic process |
| E | 0006974 | biological_process | DNA damage response |
| E | 0008380 | biological_process | RNA splicing |
| E | 0016076 | biological_process | snRNA catabolic process |
| E | 0016607 | cellular_component | nuclear speck |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0031499 | cellular_component | TRAMP complex |
| E | 0071013 | cellular_component | catalytic step 2 spliceosome |
| F | 0003676 | molecular_function | nucleic acid binding |
| F | 0008270 | molecular_function | zinc ion binding |
| G | 0003676 | molecular_function | nucleic acid binding |
| G | 0003723 | molecular_function | RNA binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | ZN_FING: CCHC-type => ECO:0000255|PROSITE-ProRule:PRU00047 |
| Chain | Residue | Details |
| B | PRO227-MET244 | |
| F | PRO227-MET244 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| B | ALA2 | |
| F | ALA2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR342 | |
| B | THR577 | |
| B | THR648 | |
| F | THR342 | |
| F | THR577 | |
| F | THR648 | |
| E | LYS167 | |
| E | THR168 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | ASP564 | |
| F | ASP564 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | LYS571 | |
| F | LYS571 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by GSK3 => ECO:0000269|PubMed:16263084, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | PRO584 | |
| F | PRO584 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER598 | |
| F | SER598 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER649 | |
| B | SER695 | |
| F | SER649 | |
| F | SER695 | |
| E | LYS24 | |
| E | LYS358 | |
| E | LYS723 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER658 | |
| F | SER658 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS505 | |
| F | LYS505 |
