7S1Y
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0006972 | biological_process | hyperosmotic response |
| A | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
| A | 0008511 | molecular_function | sodium:potassium:chloride symporter activity |
| A | 0008519 | molecular_function | ammonium channel activity |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0010818 | biological_process | T cell chemotaxis |
| A | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030321 | biological_process | transepithelial chloride transport |
| A | 0030644 | biological_process | intracellular chloride ion homeostasis |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031253 | cellular_component | cell projection membrane |
| A | 0035633 | biological_process | maintenance of blood-brain barrier |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0035865 | biological_process | cellular response to potassium ion |
| A | 0042995 | cellular_component | cell projection |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0044297 | cellular_component | cell body |
| A | 0044298 | cellular_component | cell body membrane |
| A | 0045795 | biological_process | positive regulation of cell volume |
| A | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051879 | molecular_function | Hsp90 protein binding |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055078 | biological_process | sodium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0061044 | biological_process | negative regulation of vascular wound healing |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070634 | biological_process | transepithelial ammonium transport |
| A | 0071944 | cellular_component | cell periphery |
| A | 0072488 | biological_process | ammonium transmembrane transport |
| A | 0098658 | biological_process | inorganic anion import across plasma membrane |
| A | 0098659 | biological_process | inorganic cation import across plasma membrane |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| A | 0150003 | biological_process | regulation of spontaneous synaptic transmission |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1903561 | cellular_component | extracellular vesicle |
| A | 1904450 | biological_process | positive regulation of aspartate secretion |
| A | 1904464 | biological_process | regulation of matrix metallopeptidase secretion |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| A | 1990869 | biological_process | cellular response to chemokine |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006883 | biological_process | intracellular sodium ion homeostasis |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0006972 | biological_process | hyperosmotic response |
| B | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
| B | 0008511 | molecular_function | sodium:potassium:chloride symporter activity |
| B | 0008519 | molecular_function | ammonium channel activity |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0010818 | biological_process | T cell chemotaxis |
| B | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0030321 | biological_process | transepithelial chloride transport |
| B | 0030644 | biological_process | intracellular chloride ion homeostasis |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0031253 | cellular_component | cell projection membrane |
| B | 0035633 | biological_process | maintenance of blood-brain barrier |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0035865 | biological_process | cellular response to potassium ion |
| B | 0042995 | cellular_component | cell projection |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0044297 | cellular_component | cell body |
| B | 0044298 | cellular_component | cell body membrane |
| B | 0045795 | biological_process | positive regulation of cell volume |
| B | 0046873 | molecular_function | metal ion transmembrane transporter activity |
| B | 0051087 | molecular_function | protein-folding chaperone binding |
| B | 0051879 | molecular_function | Hsp90 protein binding |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055078 | biological_process | sodium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0061044 | biological_process | negative regulation of vascular wound healing |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070634 | biological_process | transepithelial ammonium transport |
| B | 0071944 | cellular_component | cell periphery |
| B | 0072488 | biological_process | ammonium transmembrane transport |
| B | 0098658 | biological_process | inorganic anion import across plasma membrane |
| B | 0098659 | biological_process | inorganic cation import across plasma membrane |
| B | 0098719 | biological_process | sodium ion import across plasma membrane |
| B | 0150003 | biological_process | regulation of spontaneous synaptic transmission |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1903561 | cellular_component | extracellular vesicle |
| B | 1904450 | biological_process | positive regulation of aspartate secretion |
| B | 1904464 | biological_process | regulation of matrix metallopeptidase secretion |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 1990869 | biological_process | cellular response to chemokine |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | TRANSMEM: Discontinuously helical; Name=1 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ILE288-ILE317 | |
| B | ILE288-ILE317 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | GLY318-SER337 | |
| B | GLY318-SER337 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1122 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | THR338-ILE368 | |
| B | ILE625-LEU652 | |
| B | VAL693-ILE715 | |
| A | GLU431-LYS433 | |
| A | ASN506-LYS520 | |
| A | ILE625-LEU652 | |
| A | VAL693-ILE715 | |
| B | THR338-ILE368 | |
| B | GLU431-LYS433 | |
| B | ASN506-LYS520 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | GLY369-LYS396 | |
| B | GLY369-LYS396 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 192 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | GLU397-ILE406 | |
| A | PRO456-PHE487 | |
| A | CYS543-PHE599 | |
| B | GLU397-ILE406 | |
| B | PRO456-PHE487 | |
| B | CYS543-PHE599 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ASN407-TRP430 | |
| B | ASN407-TRP430 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ALA434-ILE455 | |
| B | ALA434-ILE455 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 34 |
| Details | TRANSMEM: Discontinuously helical; Name=6 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | PHE488-ALA505 | |
| B | PHE488-ALA505 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | GLY521-SER542 | |
| B | GLY521-SER542 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | THR600-LYS624 | |
| B | THR600-LYS624 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ARG653-VAL673 | |
| B | ARG653-VAL673 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ILE674-SER692 | |
| B | ILE674-SER692 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 34 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | SER716-TRP733 | |
| B | SER716-TRP733 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE |
| Chain | Residue | Details |
| A | ALA734-TYR746 | |
| B | ALA734-TYR746 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36239040, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ASN298 | |
| B | THR611 | |
| B | SER614 | |
| B | ALA615 | |
| A | GLY301 | |
| A | LEU304 | |
| A | THR611 | |
| A | SER614 | |
| A | ALA615 | |
| B | ASN298 | |
| B | GLY301 | |
| B | LEU304 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ILE299 | |
| B | ILE299 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | TRP300 | |
| B | TRP300 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO |
| Chain | Residue | Details |
| A | VAL302 | |
| B | VAL302 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | MET303 | |
| B | MET303 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0007744|PDB:7S1Y |
| Chain | Residue | Details |
| A | ALA373 | |
| A | LEU683 | |
| B | ALA373 | |
| B | LEU683 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | VAL384 | |
| B | VAL384 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ALA497 | |
| B | ALA497 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ALA498 | |
| B | ALA498 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7SMP |
| Chain | Residue | Details |
| A | GLY500 | |
| B | GLY500 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ILE501 | |
| A | LEU502 | |
| B | ILE501 | |
| B | LEU502 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7ZGO |
| Chain | Residue | Details |
| A | ALA687 | |
| B | ALA687 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER78 | |
| B | SER78 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER80 | |
| B | SER80 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:16669787 |
| Chain | Residue | Details |
| A | HIS204 | |
| A | TYR208 | |
| B | HIS204 | |
| B | TYR208 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:12145305, ECO:0000269|PubMed:16669787 |
| Chain | Residue | Details |
| A | PHE213 | |
| B | PHE213 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:12145305, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | MET218 | |
| B | MET218 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55016 |
| Chain | Residue | Details |
| A | ALA231 | |
| B | ALA231 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55016 |
| Chain | Residue | Details |
| A | LEU243 | |
| B | LEU243 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55012 |
| Chain | Residue | Details |
| A | PRO267 | |
| B | PRO267 |
| site_id | SWS_FT_FI35 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | GLN941 | |
| A | LYS995 | |
| B | GLN941 | |
| B | LYS995 |
| site_id | SWS_FT_FI36 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55012 |
| Chain | Residue | Details |
| A | PRO945 | |
| B | PRO945 |
| site_id | SWS_FT_FI37 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASP554 | |
| A | CYS563 | |
| B | ASP554 | |
| B | CYS563 |
