7RAV
Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002376 | biological_process | immune system process |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0010804 | biological_process | negative regulation of tumor necrosis factor-mediated signaling pathway |
| A | 0016045 | biological_process | detection of bacterium |
| A | 0032731 | biological_process | positive regulation of interleukin-1 beta production |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043027 | molecular_function | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045087 | biological_process | innate immune response |
| A | 0046330 | biological_process | positive regulation of JNK cascade |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| A | 0072557 | cellular_component | IPAF inflammasome complex |
| A | 0120283 | molecular_function | protein serine/threonine kinase binding |
Functional Information from PROSITE/UniProt
| site_id | PS01282 |
| Number of Residues | 69 |
| Details | BIR_REPEAT_1 BIR repeat. EeaRlesfed.WpfyahgtsprvlsaAGFvFtgkrDtvqCfsCggslgnWeegddpwkeHakwfPkCefL |
| Chain | Residue | Details |
| A | GLU159-LEU227 | |
| A | GLU278-LEU345 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 67 |
| Details | Repeat: {"description":"BIR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"BIR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 295 |
| Details | Domain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29182158","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5YUD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
