7R3A

Crystal structure of S-adenosyl-L-homocysteine hydrolase from Methanococcus maripaludis in complex with inosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004013	molecular_function	adenosylhomocysteinase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016802	molecular_function	trialkylsulfonium hydrolase activity
A	0033353	biological_process	S-adenosylmethionine cycle
B	0004013	molecular_function	adenosylhomocysteinase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016802	molecular_function	trialkylsulfonium hydrolase activity
B	0033353	biological_process	S-adenosylmethionine cycle
C	0004013	molecular_function	adenosylhomocysteinase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016787	molecular_function	hydrolase activity
C	0016802	molecular_function	trialkylsulfonium hydrolase activity
C	0033353	biological_process	S-adenosylmethionine cycle
D	0004013	molecular_function	adenosylhomocysteinase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016802	molecular_function	trialkylsulfonium hydrolase activity
D	0033353	biological_process	S-adenosylmethionine cycle
E	0004013	molecular_function	adenosylhomocysteinase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006556	biological_process	S-adenosylmethionine biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0016787	molecular_function	hydrolase activity
E	0016802	molecular_function	trialkylsulfonium hydrolase activity
E	0033353	biological_process	S-adenosylmethionine cycle
F	0004013	molecular_function	adenosylhomocysteinase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006556	biological_process	S-adenosylmethionine biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016802	molecular_function	trialkylsulfonium hydrolase activity
F	0033353	biological_process	S-adenosylmethionine cycle
G	0004013	molecular_function	adenosylhomocysteinase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006556	biological_process	S-adenosylmethionine biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0016787	molecular_function	hydrolase activity
G	0016802	molecular_function	trialkylsulfonium hydrolase activity
G	0033353	biological_process	S-adenosylmethionine cycle
H	0004013	molecular_function	adenosylhomocysteinase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006556	biological_process	S-adenosylmethionine biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0016787	molecular_function	hydrolase activity
H	0016802	molecular_function	trialkylsulfonium hydrolase activity
H	0033353	biological_process	S-adenosylmethionine cycle

Functional Information from PROSITE/UniProt

site_id	PS00738
Number of Residues	15
Details	ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. GCNpLSTQDdVAAAC

Chain	Residue	Details
A	GLY93-CYS107

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site_id	PS00739
Number of Residues	18
Details	ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKnvvVgGYGwCGRGvaS

Chain	Residue	Details
A	GLY225-SER242

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00563

Chain	Residue	Details
A	ASP143
A	ASN357
B	ASP143
B	GLU168
B	THR169
B	LYS198
B	ASP202
B	ASN203
B	GLY232
B	GLU255
B	ALA311
A	GLU168
B	ASN357
C	ASP143
C	GLU168
C	THR169
C	LYS198
C	ASP202
C	ASN203
C	GLY232
C	GLU255
C	ALA311
A	THR169
C	ASN357
D	ASP143
D	GLU168
D	THR169
D	LYS198
D	ASP202
D	ASN203
D	GLY232
D	GLU255
D	ALA311
A	LYS198
D	ASN357
E	ASP143
E	GLU168
E	THR169
E	LYS198
E	ASP202
E	ASN203
E	GLY232
E	GLU255
E	ALA311
A	ASP202
E	ASN357
F	ASP143
F	GLU168
F	THR169
F	LYS198
F	ASP202
F	ASN203
F	GLY232
F	GLU255
F	ALA311
A	ASN203
F	ASN357
G	ASP143
G	GLU168
G	THR169
G	LYS198
G	ASP202
G	ASN203
G	GLY232
G	GLU255
G	ALA311
A	GLY232
G	ASN357
H	ASP143
H	GLU168
H	THR169
H	LYS198
H	ASP202
H	ASN203
H	GLY232
H	GLU255
H	ALA311
A	GLU255
H	ASN357
A	ALA311

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