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7QPD

Structure of the human MHC I peptide-loading complex editing module

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001669cellular_componentacrosomal vesicle
C0001849molecular_functioncomplement component C1q complex binding
C0002502biological_processpeptide antigen assembly with MHC class I protein complex
C0003677molecular_functionDNA binding
C0003723molecular_functionRNA binding
C0003729molecular_functionmRNA binding
C0005049molecular_functionnuclear export signal receptor activity
C0005178molecular_functionintegrin binding
C0005506molecular_functioniron ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005783cellular_componentendoplasmic reticulum
C0005788cellular_componentendoplasmic reticulum lumen
C0005789cellular_componentendoplasmic reticulum membrane
C0005790cellular_componentsmooth endoplasmic reticulum
C0005829cellular_componentcytosol
C0005840cellular_componentribosome
C0005925cellular_componentfocal adhesion
C0006355biological_processregulation of DNA-templated transcription
C0006457biological_processprotein folding
C0006611biological_processprotein export from nucleus
C0006874biological_processintracellular calcium ion homeostasis
C0007283biological_processspermatogenesis
C0008270molecular_functionzinc ion binding
C0008284biological_processpositive regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0012505cellular_componentendomembrane system
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0017148biological_processnegative regulation of translation
C0030246molecular_functioncarbohydrate binding
C0030670cellular_componentphagocytic vesicle membrane
C0030866biological_processcortical actin cytoskeleton organization
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032355biological_processresponse to estradiol
C0032991cellular_componentprotein-containing complex
C0033018cellular_componentsarcoplasmic reticulum lumen
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
C0033574biological_processresponse to testosterone
C0034504biological_processprotein localization to nucleus
C0034975biological_processprotein folding in endoplasmic reticulum
C0036503biological_processERAD pathway
C0040020biological_processregulation of meiotic nuclear division
C0042277molecular_functionpeptide binding
C0042562molecular_functionhormone binding
C0042824cellular_componentMHC class I peptide loading complex
C0042921biological_processnuclear receptor-mediated glucocorticoid signaling pathway
C0042981biological_processregulation of apoptotic process
C0044183molecular_functionprotein folding chaperone
C0044194cellular_componentcytolytic granule
C0044322cellular_componentendoplasmic reticulum quality control compartment
C0045665biological_processnegative regulation of neuron differentiation
C0045787biological_processpositive regulation of cell cycle
C0045892biological_processnegative regulation of DNA-templated transcription
C0046872molecular_functionmetal ion binding
C0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
C0048471cellular_componentperinuclear region of cytoplasm
C0050681molecular_functionnuclear androgen receptor binding
C0050766biological_processpositive regulation of phagocytosis
C0050821biological_processprotein stabilization
C0051082molecular_functionunfolded protein binding
C0051087molecular_functionprotein-folding chaperone binding
C0051208biological_processsequestering of calcium ion
C0051604biological_processprotein maturation
C0055007biological_processcardiac muscle cell differentiation
C0060473cellular_componentcortical granule
C0070062cellular_componentextracellular exosome
C0071257biological_processcellular response to electrical stimulus
C0071285biological_processcellular response to lithium ion
C0071682cellular_componentendocytic vesicle lumen
C0090398biological_processcellular senescence
C0098553cellular_componentlumenal side of endoplasmic reticulum membrane
C0098586biological_processcellular response to virus
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0140313molecular_functionmolecular sequestering activity
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1901164biological_processnegative regulation of trophoblast cell migration
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1901652biological_processresponse to peptide
C1903416biological_processresponse to glycoside
C1904614biological_processresponse to biphenyl
C2000510biological_processpositive regulation of dendritic cell chemotaxis
E0002250biological_processadaptive immune response
E0002376biological_processimmune system process
E0002502biological_processpeptide antigen assembly with MHC class I protein complex
E0003723molecular_functionRNA binding
E0003756molecular_functionprotein disulfide isomerase activity
E0004197molecular_functioncysteine-type endopeptidase activity
E0004629molecular_functionphospholipase C activity
E0005515molecular_functionprotein binding
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005783cellular_componentendoplasmic reticulum
E0005788cellular_componentendoplasmic reticulum lumen
E0005925cellular_componentfocal adhesion
E0006457biological_processprotein folding
E0009986cellular_componentcell surface
E0015035molecular_functionprotein-disulfide reductase activity
E0015036molecular_functiondisulfide oxidoreductase activity
E0016853molecular_functionisomerase activity
E0034975biological_processprotein folding in endoplasmic reticulum
E0034976biological_processresponse to endoplasmic reticulum stress
E0042470cellular_componentmelanosome
E0042802molecular_functionidentical protein binding
E0042824cellular_componentMHC class I peptide loading complex
E0045335cellular_componentphagocytic vesicle
E0055038cellular_componentrecycling endosome membrane
E0061779cellular_componentTapasin-ERp57 complex
E0070062cellular_componentextracellular exosome
E0070527biological_processplatelet aggregation
E0097191biological_processextrinsic apoptotic signaling pathway
E0098761biological_processcellular response to interleukin-7
E0106222molecular_functionlncRNA binding
E2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
M0000139cellular_componentGolgi membrane
M0001913biological_processT cell mediated cytotoxicity
M0001916biological_processpositive regulation of T cell mediated cytotoxicity
M0002250biological_processadaptive immune response
M0002376biological_processimmune system process
M0002419biological_processT cell mediated cytotoxicity directed against tumor cell target
M0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
M0002476biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
M0002485biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
M0002486biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
M0002502biological_processpeptide antigen assembly with MHC class I protein complex
M0002726biological_processpositive regulation of T cell cytokine production
M0003723molecular_functionRNA binding
M0005102molecular_functionsignaling receptor binding
M0005515molecular_functionprotein binding
M0005615cellular_componentextracellular space
M0005783cellular_componentendoplasmic reticulum
M0005789cellular_componentendoplasmic reticulum membrane
M0005794cellular_componentGolgi apparatus
M0005797cellular_componentGolgi medial cisterna
M0005886cellular_componentplasma membrane
M0006955biological_processimmune response
M0009897cellular_componentexternal side of plasma membrane
M0009986cellular_componentcell surface
M0012507cellular_componentER to Golgi transport vesicle membrane
M0016020cellular_componentmembrane
M0016045biological_processdetection of bacterium
M0019731biological_processantibacterial humoral response
M0019882biological_processantigen processing and presentation
M0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
M0030670cellular_componentphagocytic vesicle membrane
M0030881molecular_functionbeta-2-microglobulin binding
M0031901cellular_componentearly endosome membrane
M0032729biological_processpositive regulation of type II interferon production
M0036037biological_processCD8-positive, alpha-beta T cell activation
M0042270biological_processprotection from natural killer cell mediated cytotoxicity
M0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
M0042605molecular_functionpeptide antigen binding
M0042608molecular_functionT cell receptor binding
M0042610molecular_functionCD8 receptor binding
M0042612cellular_componentMHC class I protein complex
M0042824cellular_componentMHC class I peptide loading complex
M0045087biological_processinnate immune response
M0046977molecular_functionTAP binding
M0050830biological_processdefense response to Gram-positive bacterium
M0050852biological_processT cell receptor signaling pathway
M0055038cellular_componentrecycling endosome membrane
M0062061molecular_functionTAP complex binding
M0070062cellular_componentextracellular exosome
M0070971cellular_componentendoplasmic reticulum exit site
M0098553cellular_componentlumenal side of endoplasmic reticulum membrane
M2000566biological_processpositive regulation of CD8-positive, alpha-beta T cell proliferation
M2000568biological_processpositive regulation of memory T cell activation
M2001187biological_processpositive regulation of CD8-positive, alpha-beta T cell activation
T0000139cellular_componentGolgi membrane
T0002398biological_processMHC class Ib protein complex assembly
T0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
T0002502biological_processpeptide antigen assembly with MHC class I protein complex
T0005515molecular_functionprotein binding
T0005783cellular_componentendoplasmic reticulum
T0005789cellular_componentendoplasmic reticulum membrane
T0006457biological_processprotein folding
T0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
T0010468biological_processregulation of gene expression
T0016020cellular_componentmembrane
T0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
T0023024molecular_functionMHC class I protein complex binding
T0030670cellular_componentphagocytic vesicle membrane
T0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
T0042288molecular_functionMHC class I protein binding
T0042605molecular_functionpeptide antigen binding
T0042824cellular_componentMHC class I peptide loading complex
T0044183molecular_functionprotein folding chaperone
T0046978molecular_functionTAP1 binding
T0046979molecular_functionTAP2 binding
T0050823biological_processpeptide antigen stabilization
T0051082molecular_functionunfolded protein binding
T0060090molecular_functionmolecular adaptor activity
T0061635biological_processregulation of protein complex stability
T0061779cellular_componentTapasin-ERp57 complex
T0062061molecular_functionTAP complex binding
T0065003biological_processprotein-containing complex assembly
T0098553cellular_componentlumenal side of endoplasmic reticulum membrane
Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. KDEL
ChainResidueDetails
CLYS397-LEU400

site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. LVeFFapWCGHCKrLapeY
ChainResidueDetails
ELEU25-TYR43
ELEU374-TYR392

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
BTYR78-HIS84
MTYR257-HIS263

site_idPS00803
Number of Residues16
DetailsCALRETICULIN_1 Calreticulin family signature 1. KhEQnidCGGGYVKLF
ChainResidueDetails
CLYS81-PHE96

site_idPS00804
Number of Residues9
DetailsCALRETICULIN_2 Calreticulin family signature 2. IMFGPDiCG
ChainResidueDetails
CILE113-GLY121

site_idPS00805
Number of Residues13
DetailsCALRETICULIN_REPEAT Calreticulin family repeated motif signature. IkDpDasKPEDWD
ChainResidueDetails
CILE191-ASP203
CILE208-ASP220
CILE225-ASP237

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21423620, ECO:0000269|PubMed:27840680, ECO:0007744|PDB:3POS, ECO:0007744|PDB:3POW, ECO:0007744|PDB:5LK5
ChainResidueDetails
CGLN9
CLYS45
CLYS47
CASP311

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14211
ChainResidueDetails
CTYR92
CLYS94
CTYR111
CASP118
CASP300

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS31
CLYS142
CLYS192
EHIS384
BLYS91
BLYS94

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
ChainResidueDetails
CLYS47
MTHR73
MTYR84
MTHR143
MLYS146
MTYR171

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
CASN327
MTYR159

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000255
ChainResidueDetails
MTYR59

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
MSER319
MSER325
MSER326
MSER328

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
MTYR320
ELYS228
ELYS338
ELYS470

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
MSER332
MSER335

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
MASN86

236620

PDB entries from 2025-05-28

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