7QO6

26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0005839	cellular_component	proteasome core complex
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0051603	biological_process	proteolysis involved in protein catabolic process
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0051603	biological_process	proteolysis involved in protein catabolic process
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005839	cellular_component	proteasome core complex
5	0051603	biological_process	proteolysis involved in protein catabolic process
6	0005839	cellular_component	proteasome core complex
6	0051603	biological_process	proteolysis involved in protein catabolic process
7	0000502	cellular_component	proteasome complex
7	0003674	molecular_function	molecular_function
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0005839	cellular_component	proteasome core complex
7	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0034515	cellular_component	proteasome storage granule
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0043248	biological_process	proteasome assembly
7	0051603	biological_process	proteolysis involved in protein catabolic process
8	0004843	molecular_function	cysteine-type deubiquitinase activity
8	0016579	biological_process	protein deubiquitination
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0005524	molecular_function	ATP binding
H	0016887	molecular_function	ATP hydrolysis activity
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
J	0005524	molecular_function	ATP binding
J	0016887	molecular_function	ATP hydrolysis activity
K	0005524	molecular_function	ATP binding
K	0016887	molecular_function	ATP hydrolysis activity
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
M	0005524	molecular_function	ATP binding
M	0016887	molecular_function	ATP hydrolysis activity
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0034515	cellular_component	proteasome storage granule
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043248	biological_process	proteasome assembly
S	0000502	cellular_component	proteasome complex
S	0030234	molecular_function	enzyme regulator activity
S	0042176	biological_process	regulation of protein catabolic process
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005838	cellular_component	proteasome regulatory particle
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0003674	molecular_function	molecular_function
Y	0005515	molecular_function	protein binding
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0006457	biological_process	protein folding
Y	0006511	biological_process	ubiquitin-dependent protein catabolic process
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0030447	biological_process	filamentous growth
Y	0034515	cellular_component	proteasome storage granule
Y	0035753	biological_process	maintenance of DNA trinucleotide repeats
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Y	0044183	molecular_function	protein folding chaperone
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0051726	biological_process	regulation of cell cycle
Y	0060090	molecular_function	molecular adaptor activity
Y	0070390	cellular_component	transcription export complex 2
Y	0072742	biological_process	SAGA complex localization to transcription regulatory region
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0030234	molecular_function	enzyme regulator activity
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0034515	cellular_component	proteasome storage granule
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0051603	biological_process	proteolysis involved in protein catabolic process
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0051603	biological_process	proteolysis involved in protein catabolic process
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	proteolysis involved in protein catabolic process
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0051603	biological_process	proteolysis involved in protein catabolic process
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006508	biological_process	proteolysis
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	proteolysis involved in protein catabolic process
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005839	cellular_component	proteasome core complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
j	0005839	cellular_component	proteasome core complex
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005839	cellular_component	proteasome core complex
l	0051603	biological_process	proteolysis involved in protein catabolic process
m	0005839	cellular_component	proteasome core complex
m	0051603	biological_process	proteolysis involved in protein catabolic process
n	0000502	cellular_component	proteasome complex
n	0003674	molecular_function	molecular_function
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0034515	cellular_component	proteasome storage granule
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0043248	biological_process	proteasome assembly
n	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
9	LYS27-ASP52

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DDDEIDV

Chain	Residue	Details
U	ASP243-VAL249

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site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA

Chain	Residue	Details
f	TYR6-ALA28
a	TYR12-ALA34
c	TYR6-SER28
e	TYR8-ALA30
g	TYR8-ALA30
d	TYR4-ALA26
b	TYR5-ALA27

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkIImATNrldiLDpALl.R

Chain	Residue	Details
J	ILE288-ARG306
L	THR321-ARG339
I	VAL322-ARG340
K	VAL312-ARG330
M	VAL321-ARG339
H	ILE349-ARG367

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD

Chain	Residue	Details
7	ILE45-ASP92
j	VAL13-ASP59
i	VAL33-ASP80
k	LEU5-ASP52
6	LEU21-ASP68
c	ILE36-ASP83
d	VAL34-ASP81
l	LEU79-ASP126
h	MET13-ASP60

---

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GFknmGNtCYLNAtLQ

Chain	Residue	Details
8	GLY110-GLN125

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site_id	PS00973
Number of Residues	19
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiGVitHqGanses.GHY

Chain	Residue	Details
8	TYR430-TYR448

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:12504901, ECO:0007744|PubMed:22814378

Chain	Residue	Details
N	SER2
Z	SER178

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
N	THR801
N	THR932

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17287358

Chain	Residue	Details
Z	THR24

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
Z	SER187
Z	SER695

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