7QO6

26S proteasome Rpt1-RK -Ubp6-UbVS complex in the s2 state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0030163	biological_process	protein catabolic process
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0030163	biological_process	protein catabolic process
3	0005839	cellular_component	proteasome core complex
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0030163	biological_process	protein catabolic process
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0030163	biological_process	protein catabolic process
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005839	cellular_component	proteasome core complex
5	0030163	biological_process	protein catabolic process
6	0005839	cellular_component	proteasome core complex
6	0030163	biological_process	protein catabolic process
7	0003674	molecular_function	molecular_function
7	0005515	molecular_function	protein binding
7	0005634	cellular_component	nucleus
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0005839	cellular_component	proteasome core complex
7	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0030163	biological_process	protein catabolic process
7	0034515	cellular_component	proteasome storage granule
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0043248	biological_process	proteasome assembly
8	0004843	molecular_function	cysteine-type deubiquitinase activity
8	0016579	biological_process	protein deubiquitination
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0030163	biological_process	protein catabolic process
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0030163	biological_process	protein catabolic process
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0030163	biological_process	protein catabolic process
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0030163	biological_process	protein catabolic process
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0030163	biological_process	protein catabolic process
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0030163	biological_process	protein catabolic process
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0030163	biological_process	protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0030163	biological_process	protein catabolic process
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0005524	molecular_function	ATP binding
H	0016887	molecular_function	ATP hydrolysis activity
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005839	cellular_component	proteasome core complex
i	0030163	biological_process	protein catabolic process
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
j	0005839	cellular_component	proteasome core complex
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0030163	biological_process	protein catabolic process
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0005524	molecular_function	ATP binding
J	0016887	molecular_function	ATP hydrolysis activity
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0030163	biological_process	protein catabolic process
K	0005524	molecular_function	ATP binding
K	0016887	molecular_function	ATP hydrolysis activity
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005839	cellular_component	proteasome core complex
l	0030163	biological_process	protein catabolic process
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
m	0005839	cellular_component	proteasome core complex
m	0030163	biological_process	protein catabolic process
M	0005524	molecular_function	ATP binding
M	0016887	molecular_function	ATP hydrolysis activity
n	0003674	molecular_function	molecular_function
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0030163	biological_process	protein catabolic process
n	0034515	cellular_component	proteasome storage granule
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0043248	biological_process	proteasome assembly
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0034515	cellular_component	proteasome storage granule
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043248	biological_process	proteasome assembly
S	0000502	cellular_component	proteasome complex
S	0030234	molecular_function	enzyme regulator activity
S	0042176	biological_process	regulation of protein catabolic process
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
U	0005515	molecular_function	protein binding
U	0005838	cellular_component	proteasome regulatory particle
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0003674	molecular_function	molecular_function
Y	0005515	molecular_function	protein binding
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0006457	biological_process	protein folding
Y	0006511	biological_process	ubiquitin-dependent protein catabolic process
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0030447	biological_process	filamentous growth
Y	0034515	cellular_component	proteasome storage granule
Y	0035753	biological_process	maintenance of DNA trinucleotide repeats
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Y	0044183	molecular_function	protein folding chaperone
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0051726	biological_process	regulation of cell cycle
Y	0060090	molecular_function	molecular adaptor activity
Y	0070390	cellular_component	transcription export complex 2
Y	0072742	biological_process	SAGA complex localization to transcription regulatory region
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0030234	molecular_function	enzyme regulator activity
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0034515	cellular_component	proteasome storage granule
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
9	LYS27-ASP52

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DDDEIDV

Chain	Residue	Details
U	ASP243-VAL249

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsnSvFSPdGRnfQVEYAvkA

Chain	Residue	Details
g	TYR8-ALA30
c	TYR6-SER28
b	TYR5-ALA27
d	TYR4-ALA26
a	TYR12-ALA34
e	TYR8-ALA30
f	TYR6-ALA28

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVImATNradtLDpALl.R

Chain	Residue	Details
K	VAL312-ARG330
I	VAL322-ARG340
J	ILE288-ARG306
L	THR321-ARG339
H	ILE349-ARG367
M	VAL321-ARG339

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIrVqdSVILASSkavtrgisvlkdsdd.KtrqlsphtlmsfaGeaGD

Chain	Residue	Details
k	LEU5-ASP52
h	MET13-ASP60
c	ILE36-ASP83
i	VAL33-ASP80
7	ILE45-ASP92
6	LEU21-ASP68
j	VAL13-ASP59
d	VAL34-ASP81
l	LEU79-ASP126

---

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GFknmGNtCYLNAtLQ

Chain	Residue	Details
8	GLY110-GLN125

---

site_id	PS00973
Number of Residues	19
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiGVitHqGanses.GHY

Chain	Residue	Details
8	TYR430-TYR448

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	65
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	74
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	68
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	74
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	65
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	66
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	66
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	64
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	34
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	37
Details	Repeat: {"description":"PC 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	36
Details	Repeat: {"description":"PC 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	135
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"12504901","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	168
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---