7QNE
Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0004890 | molecular_function | GABA-A receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006821 | biological_process | chloride transport |
A | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0004890 | molecular_function | GABA-A receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0004890 | molecular_function | GABA-A receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006821 | biological_process | chloride transport |
C | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0004890 | molecular_function | GABA-A receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006821 | biological_process | chloride transport |
D | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0004890 | molecular_function | GABA-A receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
site_id | PS00236 |
Number of Residues | 15 |
Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMhLedFPmDahaC |
Chain | Residue | Details |
A | CYS139-CYS153 | |
B | CYS136-CYS150 | |
C | CYS151-CYS165 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 248 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
C | GLN1-PHE236 | |
C | ARG284-ALA295 | |
C | LEU434-LEU436 | |
D | GLN1-PHE226 | |
D | ASN275-THR284 | |
D | TYR415-GLN429 |
site_id | SWS_FT_FI2 |
Number of Residues | 83 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
C | THR237-ILE257 | |
C | ALA264-ALA283 | |
C | MET296-PHE320 | |
C | TYR413-TYR433 | |
D | VAL227-LEU247 | |
D | PRO253-ARG274 | |
D | ALA285-THR306 | |
D | LEU395-THR414 |
site_id | SWS_FT_FI3 |
Number of Residues | 96 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
C | ASN258-PRO263 | |
C | VAL321-SER412 | |
D | ASN248-VAL252 | |
D | VAL307-ARG394 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
C | ASN13 | |
C | ASN90 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
C | ASN208 | |
D | THR130 | |
E | ASP95 | |
E | PHE200 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30266951 |
Chain | Residue | Details |
A | TRP246 | |
D | TRP246 | |
B | THR202 | |
E | TYR97 | |
E | SER156 | |
E | THR202 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN11 | |
D | ASN11 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
A | ASN111 | |
D | ASN111 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
Chain | Residue | Details |
B | ASN8 | |
E | ASN8 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
Chain | Residue | Details |
B | ASN80 | |
E | ASN80 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
Chain | Residue | Details |
B | ASN149 | |
E | ASN149 |