6I53

Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc

Summary for 6I53

Entry DOI	10.2210/pdb6i53/pdb
EMDB information	4411
Descriptor	Gamma-aminobutyric acid receptor subunit beta-3, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, Gamma-aminobutyric acid receptor subunit alpha-1, ... (10 entities in total)
Functional Keywords	ligand gated ion channel cys-loop receptor gaba-a receptor, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	294283.60
Authors	Laverty, D.,Desai, R.,Uchanski, T.,Masiulis, S.,Wojciech, J.S.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-11-12, release date: 2019-01-02, Last modification date: 2022-03-30)
Primary citation	Laverty, D.,Desai, R.,Uchanski, T.,Masiulis, S.,Stec, W.J.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer. Nature, 565:516-520, 2019 Cited by PubMed: 30602789 DOI: 10.1038/s41586-018-0833-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation