7QNE
Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | GABA(A) receptor subunit alpha-1 | polymer | 456 | 51865.7 | 2 | UniProt (A0A1B0GV38) Pfam (PF02931) Pfam (PF02932) UniProt (by SIFTS) (P14867) In PDB | Homo sapiens (human) | Gamma-aminobutyric acid receptor subunit alpha-1 |
2 | B, E | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 473 | 54180.3 | 2 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit beta-3 |
3 | C | GABA(A) receptor subunit gamma-2 | polymer | 495 | 56922.1 | 1 | UniProt (A0A286YFI6) Pfam (PF02931) Pfam (PF02932) UniProt (by SIFTS) (P18507) In PDB | Homo sapiens (human) | Gamma-aminobutyric acid receptor subunit gamma-2 |
4 | G | Megabody Mb38 | polymer | 123 | 13462.9 | 1 | Lama glama | ||
5 | a | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
6 | b, e | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
7 | F, H | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
8 | d | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
9 | A, D | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) | |||
10 | A | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) | |||
11 | A, B, C, E | DECANE | non-polymer | 142.3 | 4 | Chemie (D10) | |||
12 | A, C, D | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
13 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
14 | D | ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{H}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | non-polymer | 326.3 | 1 | Chemie (EIE) |
Sequence modifications
C: -38 - 436 (UniProt: A0A286YFI6)
PDB | External Database | Details |
---|---|---|
- | Pro 376 | deletion |
- | Ile 377 | deletion |
- | His 378 | deletion |
- | His 379 | deletion |
- | His 380 | deletion |
- | Ile 381 | deletion |
- | Gly 382 | deletion |
- | Asp 383 | deletion |
- | Ile 384 | deletion |
- | Val 385 | deletion |
- | Glu 386 | deletion |
- | Lys 387 | deletion |
- | Gln 388 | deletion |
- | Pro 389 | deletion |
- | Arg 390 | deletion |
- | Ile 391 | deletion |
- | Ser 392 | deletion |
- | Arg 393 | deletion |
- | Glu 394 | deletion |
- | Gln 395 | deletion |
- | Leu 396 | deletion |
- | Thr 397 | deletion |
- | Asp 398 | deletion |
Leu 338 | Ser 400 | conflict |
Leu 339 | Pro 401 | conflict |
Arg 340 | Ser 402 | conflict |
Met 341 | Leu 403 | conflict |
Phe 342 | Pro 404 | conflict |
Phe 344 | Ser 406 | conflict |
Lys 345 | Gln 407 | conflict |
Gly 437 | - | expression tag |
Gly 438 | - | expression tag |
Ser 439 | - | expression tag |
Gly 440 | - | expression tag |
Gly 441 | - | expression tag |
Ser 442 | - | expression tag |
Gly 443 | - | expression tag |
Gly 444 | - | expression tag |
Ser 445 | - | expression tag |
Gly 446 | - | expression tag |
Lys 447 | - | expression tag |
Thr 448 | - | expression tag |
Glu 449 | - | expression tag |
Thr 450 | - | expression tag |
Ser 451 | - | expression tag |
Gln 452 | - | expression tag |
Val 453 | - | expression tag |
Ala 454 | - | expression tag |
Pro 455 | - | expression tag |
Ala 456 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 282477.0 | |
Branched | Number of molecules | 6 |
Total formula weight | 5464.9 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2830.4 | |
All* | Total formula weight | 290772.3 |