Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Q3N

Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0007155	biological_process	cell adhesion
F	0009289	cellular_component	pilus
U	0000922	cellular_component	spindle pole
U	0001822	biological_process	kidney development
U	0002251	biological_process	organ or tissue specific immune response
U	0003091	biological_process	renal water homeostasis
U	0003094	biological_process	glomerular filtration
U	0005509	molecular_function	calcium ion binding
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005615	cellular_component	extracellular space
U	0005783	cellular_component	endoplasmic reticulum
U	0005796	cellular_component	Golgi lumen
U	0005886	cellular_component	plasma membrane
U	0005929	cellular_component	cilium
U	0006629	biological_process	lipid metabolic process
U	0006874	biological_process	intracellular calcium ion homeostasis
U	0006883	biological_process	intracellular sodium ion homeostasis
U	0006914	biological_process	autophagy
U	0006915	biological_process	apoptotic process
U	0006954	biological_process	inflammatory response
U	0006968	biological_process	cellular defense response
U	0006986	biological_process	response to unfolded protein
U	0007029	biological_process	endoplasmic reticulum organization
U	0007157	biological_process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
U	0007159	biological_process	leukocyte cell-cell adhesion
U	0008217	biological_process	regulation of blood pressure
U	0008285	biological_process	negative regulation of cell population proliferation
U	0008380	biological_process	RNA splicing
U	0009410	biological_process	response to xenobiotic stimulus
U	0009414	biological_process	response to water deprivation
U	0009986	cellular_component	cell surface
U	0010467	biological_process	gene expression
U	0015747	biological_process	urate transport
U	0016020	cellular_component	membrane
U	0016323	cellular_component	basolateral plasma membrane
U	0016324	cellular_component	apical plasma membrane
U	0019864	molecular_function	IgG binding
U	0019898	cellular_component	extrinsic component of membrane
U	0030643	biological_process	intracellular phosphate ion homeostasis
U	0030644	biological_process	intracellular chloride ion homeostasis
U	0032496	biological_process	response to lipopolysaccharide
U	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
U	0033555	biological_process	multicellular organismal response to stress
U	0034620	biological_process	cellular response to unfolded protein
U	0034976	biological_process	response to endoplasmic reticulum stress
U	0035809	biological_process	regulation of urine volume
U	0036503	biological_process	ERAD pathway
U	0044861	biological_process	protein transport into plasma membrane raft
U	0045087	biological_process	innate immune response
U	0046720	biological_process	citric acid secretion
U	0048871	biological_process	multicellular organismal-level homeostasis
U	0048878	biological_process	chemical homeostasis
U	0050801	biological_process	monoatomic ion homeostasis
U	0050829	biological_process	defense response to Gram-negative bacterium
U	0050891	biological_process	multicellular organismal-level water homeostasis
U	0051223	biological_process	regulation of protein transport
U	0055062	biological_process	phosphate ion homeostasis
U	0055064	biological_process	chloride ion homeostasis
U	0055074	biological_process	calcium ion homeostasis
U	0055075	biological_process	potassium ion homeostasis
U	0055078	biological_process	sodium ion homeostasis
U	0060073	biological_process	micturition
U	0060170	cellular_component	ciliary membrane
U	0061077	biological_process	chaperone-mediated protein folding
U	0070062	cellular_component	extracellular exosome
U	0070294	biological_process	renal sodium ion absorption
U	0071918	biological_process	urea transmembrane transport
U	0072044	biological_process	collecting duct development
U	0072051	biological_process	juxtaglomerular apparatus development
U	0072070	biological_process	loop of Henle development
U	0072218	biological_process	metanephric ascending thin limb development
U	0072221	biological_process	metanephric distal convoluted tubule development
U	0072233	biological_process	metanephric thick ascending limb development
U	0072665	biological_process	protein localization to vacuole
U	0097190	biological_process	apoptotic signaling pathway
U	0097709	biological_process	connective tissue replacement
U	0097744	biological_process	renal urate salt excretion
U	0098552	cellular_component	side of membrane
U	0140367	biological_process	antibacterial innate immune response
U	1990266	biological_process	neutrophil migration

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFsCvC

Chain	Residue	Details
U	CYS83-CYS94
U	CYS126-CYS137

site_id	PS00682
Number of Residues	41
Details	ZP_1 ZP domain signature. VgtmldggDlsrFaLlMtnCYaTPss..NaTdplkyfIIqdr.C

Chain	Residue	Details
U	VAL487-CYS527

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtCqeGFtgdglt..C

Chain	Residue	Details
U	CYS50-CYS63
U	CYS92-CYS106
U	CYS135-CYS150

site_id	PS01187
Number of Residues	28
Details	EGF_CA Calcium-binding EGF-like domain signature. DlDECaipgahn.......Csanss..CvNtpgsFsC

Chain	Residue	Details
U	ASP65-CYS92
U	ASP108-CYS135

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage => ECO:0000269\|PubMed:18375198

Chain	Residue	Details
U	PHE587

site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:32616672

Chain	Residue	Details
U	ASN38

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:35273390, ECO:0007744\|PDB:7PFP, ECO:0007744\|PDB:7Q3N

Chain	Residue	Details
U	ASN76
U	ASN80

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:22171320, ECO:0000269\|PubMed:26811476, ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:35273390, ECO:0007744\|PDB:7PFP, ECO:0007744\|PDB:7Q3N

Chain	Residue	Details
U	ASN232

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:35273390, ECO:0007744\|PDB:7PFP, ECO:0007744\|PDB:7Q3N

Chain	Residue	Details
U	ASN275

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:22171320, ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:33196145, ECO:0000269\|PubMed:35273390, ECO:0007744\|PDB:6TQK, ECO:0007744\|PDB:6TQL, ECO:0007744\|PDB:7PFP

Chain	Residue	Details
U	ASN322

site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:22171320, ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:32815518, ECO:0000269\|PubMed:33196145, ECO:0000269\|PubMed:35273390, ECO:0007744\|PDB:6TQK, ECO:0007744\|PDB:6TQL, ECO:0007744\|PDB:6ZS5, ECO:0007744\|PDB:6ZYA, ECO:0007744\|PDB:7PFP

Chain	Residue	Details
U	ASN396

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; alternate => ECO:0000269\|PubMed:32616672, ECO:0000269\|PubMed:32815518, ECO:0000269\|PubMed:33196145, ECO:0007744\|PDB:6TQK, ECO:0007744\|PDB:6TQL, ECO:0007744\|PDB:6ZS5, ECO:0007744\|PDB:6ZYA, ECO:0007744\|PDB:7PFP

Chain	Residue	Details
U	ASN513

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)