Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PQH

Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000329	cellular_component	fungal-type vacuole membrane
A	0001558	biological_process	regulation of cell growth
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005774	cellular_component	vacuolar membrane
A	0005886	cellular_component	plasma membrane
A	0007584	biological_process	response to nutrient
A	0009267	biological_process	cellular response to starvation
A	0010494	cellular_component	cytoplasmic stress granule
A	0010506	biological_process	regulation of autophagy
A	0030307	biological_process	positive regulation of cell growth
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031929	biological_process	TOR signaling
A	0031931	cellular_component	TORC1 complex
A	0043130	molecular_function	ubiquitin binding
A	0051726	biological_process	regulation of cell cycle
A	0071230	biological_process	cellular response to amino acid stimulus
B	0000329	cellular_component	fungal-type vacuole membrane
B	0001558	biological_process	regulation of cell growth
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005774	cellular_component	vacuolar membrane
B	0005886	cellular_component	plasma membrane
B	0007584	biological_process	response to nutrient
B	0009267	biological_process	cellular response to starvation
B	0010494	cellular_component	cytoplasmic stress granule
B	0010506	biological_process	regulation of autophagy
B	0030307	biological_process	positive regulation of cell growth
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031929	biological_process	TOR signaling
B	0031931	cellular_component	TORC1 complex
B	0043130	molecular_function	ubiquitin binding
B	0051726	biological_process	regulation of cell cycle
B	0071230	biological_process	cellular response to amino acid stimulus
C	0000139	cellular_component	Golgi membrane
C	0001558	biological_process	regulation of cell growth
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005774	cellular_component	vacuolar membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007584	biological_process	response to nutrient
C	0010008	cellular_component	endosome membrane
C	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
C	0031505	biological_process	fungal-type cell wall organization
C	0031929	biological_process	TOR signaling
C	0031930	biological_process	mitochondria-nucleus signaling pathway
C	0031931	cellular_component	TORC1 complex
C	0031932	cellular_component	TORC2 complex
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0034399	cellular_component	nuclear periphery
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0051726	biological_process	regulation of cell cycle
C	0098588	cellular_component	bounding membrane of organelle
D	0000139	cellular_component	Golgi membrane
D	0001558	biological_process	regulation of cell growth
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005774	cellular_component	vacuolar membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007584	biological_process	response to nutrient
D	0010008	cellular_component	endosome membrane
D	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
D	0031505	biological_process	fungal-type cell wall organization
D	0031929	biological_process	TOR signaling
D	0031930	biological_process	mitochondria-nucleus signaling pathway
D	0031931	cellular_component	TORC1 complex
D	0031932	cellular_component	TORC2 complex
D	0032956	biological_process	regulation of actin cytoskeleton organization
D	0034399	cellular_component	nuclear periphery
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0051726	biological_process	regulation of cell cycle
D	0098588	cellular_component	bounding membrane of organelle
E	0000166	molecular_function	nucleotide binding
E	0000329	cellular_component	fungal-type vacuole membrane
E	0001558	biological_process	regulation of cell growth
E	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005774	cellular_component	vacuolar membrane
E	0005886	cellular_component	plasma membrane
E	0006995	biological_process	cellular response to nitrogen starvation
E	0007010	biological_process	cytoskeleton organization
E	0007584	biological_process	response to nutrient
E	0010507	biological_process	negative regulation of autophagy
E	0016242	biological_process	negative regulation of macroautophagy
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
E	0031929	biological_process	TOR signaling
E	0031931	cellular_component	TORC1 complex
E	0031932	cellular_component	TORC2 complex
E	0035025	biological_process	positive regulation of Rho protein signal transduction
E	0038201	cellular_component	TOR complex
E	0038202	biological_process	TORC1 signaling
E	0042254	biological_process	ribosome biogenesis
E	0044877	molecular_function	protein-containing complex binding
E	0045807	biological_process	positive regulation of endocytosis
E	0051726	biological_process	regulation of cell cycle
E	0106310	molecular_function	protein serine kinase activity
E	1905356	biological_process	regulation of snRNA pseudouridine synthesis
F	0000166	molecular_function	nucleotide binding
F	0000329	cellular_component	fungal-type vacuole membrane
F	0001558	biological_process	regulation of cell growth
F	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005774	cellular_component	vacuolar membrane
F	0005886	cellular_component	plasma membrane
F	0006995	biological_process	cellular response to nitrogen starvation
F	0007010	biological_process	cytoskeleton organization
F	0007584	biological_process	response to nutrient
F	0010507	biological_process	negative regulation of autophagy
F	0016242	biological_process	negative regulation of macroautophagy
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
F	0031929	biological_process	TOR signaling
F	0031931	cellular_component	TORC1 complex
F	0031932	cellular_component	TORC2 complex
F	0035025	biological_process	positive regulation of Rho protein signal transduction
F	0038201	cellular_component	TOR complex
F	0038202	biological_process	TORC1 signaling
F	0042254	biological_process	ribosome biogenesis
F	0044877	molecular_function	protein-containing complex binding
F	0045807	biological_process	positive regulation of endocytosis
F	0051726	biological_process	regulation of cell cycle
F	0106310	molecular_function	protein serine kinase activity
F	1905356	biological_process	regulation of snRNA pseudouridine synthesis
G	0000329	cellular_component	fungal-type vacuole membrane
G	0001558	biological_process	regulation of cell growth
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005774	cellular_component	vacuolar membrane
G	0005886	cellular_component	plasma membrane
G	0007584	biological_process	response to nutrient
G	0009267	biological_process	cellular response to starvation
G	0010494	cellular_component	cytoplasmic stress granule
G	0010506	biological_process	regulation of autophagy
G	0030307	biological_process	positive regulation of cell growth
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031929	biological_process	TOR signaling
G	0031931	cellular_component	TORC1 complex
G	0043130	molecular_function	ubiquitin binding
G	0051726	biological_process	regulation of cell cycle
G	0071230	biological_process	cellular response to amino acid stimulus
H	0000166	molecular_function	nucleotide binding
H	0000329	cellular_component	fungal-type vacuole membrane
H	0001558	biological_process	regulation of cell growth
H	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005774	cellular_component	vacuolar membrane
H	0005886	cellular_component	plasma membrane
H	0006995	biological_process	cellular response to nitrogen starvation
H	0007010	biological_process	cytoskeleton organization
H	0007584	biological_process	response to nutrient
H	0010507	biological_process	negative regulation of autophagy
H	0016242	biological_process	negative regulation of macroautophagy
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
H	0031929	biological_process	TOR signaling
H	0031931	cellular_component	TORC1 complex
H	0031932	cellular_component	TORC2 complex
H	0035025	biological_process	positive regulation of Rho protein signal transduction
H	0038201	cellular_component	TOR complex
H	0038202	biological_process	TORC1 signaling
H	0042254	biological_process	ribosome biogenesis
H	0044877	molecular_function	protein-containing complex binding
H	0045807	biological_process	positive regulation of endocytosis
H	0051726	biological_process	regulation of cell cycle
H	0106310	molecular_function	protein serine kinase activity
H	1905356	biological_process	regulation of snRNA pseudouridine synthesis
I	0000139	cellular_component	Golgi membrane
I	0001558	biological_process	regulation of cell growth
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005774	cellular_component	vacuolar membrane
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0007165	biological_process	signal transduction
I	0007584	biological_process	response to nutrient
I	0010008	cellular_component	endosome membrane
I	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
I	0031505	biological_process	fungal-type cell wall organization
I	0031929	biological_process	TOR signaling
I	0031930	biological_process	mitochondria-nucleus signaling pathway
I	0031931	cellular_component	TORC1 complex
I	0031932	cellular_component	TORC2 complex
I	0032956	biological_process	regulation of actin cytoskeleton organization
I	0034399	cellular_component	nuclear periphery
I	0043539	molecular_function	protein serine/threonine kinase activator activity
I	0051726	biological_process	regulation of cell cycle
I	0098588	cellular_component	bounding membrane of organelle
J	0000329	cellular_component	fungal-type vacuole membrane
J	0001558	biological_process	regulation of cell growth
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005774	cellular_component	vacuolar membrane
J	0005886	cellular_component	plasma membrane
J	0007584	biological_process	response to nutrient
J	0009267	biological_process	cellular response to starvation
J	0010494	cellular_component	cytoplasmic stress granule
J	0010506	biological_process	regulation of autophagy
J	0030307	biological_process	positive regulation of cell growth
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031929	biological_process	TOR signaling
J	0031931	cellular_component	TORC1 complex
J	0043130	molecular_function	ubiquitin binding
J	0051726	biological_process	regulation of cell cycle
J	0071230	biological_process	cellular response to amino acid stimulus
K	0000166	molecular_function	nucleotide binding
K	0000329	cellular_component	fungal-type vacuole membrane
K	0001558	biological_process	regulation of cell growth
K	0004430	molecular_function	1-phosphatidylinositol 4-kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005774	cellular_component	vacuolar membrane
K	0005886	cellular_component	plasma membrane
K	0006995	biological_process	cellular response to nitrogen starvation
K	0007010	biological_process	cytoskeleton organization
K	0007584	biological_process	response to nutrient
K	0010507	biological_process	negative regulation of autophagy
K	0016242	biological_process	negative regulation of macroautophagy
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
K	0031929	biological_process	TOR signaling
K	0031931	cellular_component	TORC1 complex
K	0031932	cellular_component	TORC2 complex
K	0035025	biological_process	positive regulation of Rho protein signal transduction
K	0038201	cellular_component	TOR complex
K	0038202	biological_process	TORC1 signaling
K	0042254	biological_process	ribosome biogenesis
K	0044877	molecular_function	protein-containing complex binding
K	0045807	biological_process	positive regulation of endocytosis
K	0051726	biological_process	regulation of cell cycle
K	0106310	molecular_function	protein serine kinase activity
K	1905356	biological_process	regulation of snRNA pseudouridine synthesis
L	0000139	cellular_component	Golgi membrane
L	0001558	biological_process	regulation of cell growth
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005774	cellular_component	vacuolar membrane
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0007165	biological_process	signal transduction
L	0007584	biological_process	response to nutrient
L	0010008	cellular_component	endosome membrane
L	0030950	biological_process	establishment or maintenance of actin cytoskeleton polarity
L	0031505	biological_process	fungal-type cell wall organization
L	0031929	biological_process	TOR signaling
L	0031930	biological_process	mitochondria-nucleus signaling pathway
L	0031931	cellular_component	TORC1 complex
L	0031932	cellular_component	TORC2 complex
L	0032956	biological_process	regulation of actin cytoskeleton organization
L	0034399	cellular_component	nuclear periphery
L	0043539	molecular_function	protein serine/threonine kinase activator activity
L	0051726	biological_process	regulation of cell cycle
L	0098588	cellular_component	bounding membrane of organelle

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAgyDhTIRFWEA

Chain	Residue	Details
C	LEU5-ALA19
C	MET90-VAL104
C	LEU131-LEU145
C	LEU265-LEU279
A	LEU1418-ILE1432

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDIRQDslvmQ

Chain	Residue	Details
E	LEU2127-GLN2141

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMtgYILgLgDRHpsN

Chain	Residue	Details
E	SER2264-ASN2284

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	224
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	216
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	222
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	164
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	316
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	356
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	316
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	316
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	156
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	156
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	76
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	76
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	152
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	148
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	148
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	148
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	156
Details	Repeat: {"description":"HEAT 11"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	128
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	24
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	32
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	100
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)