Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PQC

tau-microtubule structural ensemble based on CryoEM data

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0015630	cellular_component	microtubule cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0003924	molecular_function	GTPase activity
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003924	molecular_function	GTPase activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0003924	molecular_function	GTPase activity
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0016787	molecular_function	hydrolase activity
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0015630	cellular_component	microtubule cytoskeleton
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0003924	molecular_function	GTPase activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0015630	cellular_component	microtubule cytoskeleton
N	0016787	molecular_function	hydrolase activity
N	0046872	molecular_function	metal ion binding
O	0008017	molecular_function	microtubule binding
O	0015631	molecular_function	tubulin binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
A	MET1-ILE4

site_id	PS00229
Number of Residues	13
Details	TAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG

Chain	Residue	Details
O	GLY261-GLY273
O	GLY292-GLY304
O	GLY323-GLY335
O	GLY355-GLY367

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Not glycated => ECO:0000269\|PubMed:9326300

Chain	Residue	Details
O	ASN381
C	GLY142
C	THR143
C	GLY144
C	ASN204
C	ASN226
E	GLN11
E	SER138
E	GLY142
E	THR143
E	GLY144
O	GLU391
E	ASN204
E	ASN226
G	GLN11
G	SER138
G	GLY142
G	THR143
G	GLY144
G	ASN204
G	ASN226
I	GLN11
O	ILE392
I	SER138
I	GLY142
I	THR143
I	GLY144
I	ASN204
I	ASN226
K	GLN11
K	SER138
K	GLY142
K	THR143
O	TYR394
K	GLY144
K	ASN204
K	ASN226
M	GLN11
M	SER138
M	GLY142
M	THR143
M	GLY144
M	ASN204
M	ASN226
J	GLU254
L	GLU254
N	GLU254
C	GLN11
C	SER138

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by SGK1 => ECO:0000269\|PubMed:16982696

Chain	Residue	Details
O	SER214
D	GLU71
D	SER140
D	GLY144
D	THR145
D	THR179
D	ASN206
D	ASN228
F	GLN11
F	GLU71
F	SER140
B	GLU71
F	GLY144
F	THR145
F	THR179
F	ASN206
F	ASN228
H	GLN11
H	GLU71
H	SER140
H	GLY144
H	THR145
B	SER140
H	THR179
H	ASN206
H	ASN228
J	GLN11
J	GLU71
J	SER140
J	GLY144
J	THR145
J	THR179
J	ASN206
B	GLY144
J	ASN228
L	GLN11
L	GLU71
L	SER140
L	GLY144
L	THR145
L	THR179
L	ASN206
L	ASN228
N	GLN11
B	THR145
N	GLU71
N	SER140
N	GLY144
N	THR145
N	THR179
N	ASN206
N	ASN228
B	THR179
B	ASN206
B	ASN228
D	GLN11

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro => ECO:0000269\|PubMed:9326300

Chain	Residue	Details
O	LYS383
D	TYR451
F	TYR451
H	TYR451
J	TYR451
L	TYR451
N	TYR451

site_id	SWS_FT_FI4
Number of Residues	7
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	LYS40
D	LYS40
F	LYS40
H	LYS40
J	LYS40
L	LYS40
N	LYS40

site_id	SWS_FT_FI5
Number of Residues	14
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	SER48
J	SER232
L	SER48
L	SER232
N	SER48
N	SER232
B	SER232
D	SER48
D	SER232
F	SER48
F	SER232
H	SER48
H	SER232
J	SER48

site_id	SWS_FT_FI6
Number of Residues	7
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
B	TYR282
I	THR290
K	THR285
K	THR290
M	THR285
M	THR290
D	TYR282
F	TYR282
H	TYR282
J	TYR282
L	TYR282
N	TYR282
G	THR290
I	THR285

site_id	SWS_FT_FI7
Number of Residues	7
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	ARG339
D	ARG339
F	ARG339
H	ARG339
J	ARG339
L	ARG339
N	ARG339

site_id	SWS_FT_FI8
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68373

Chain	Residue	Details
B	SER439
D	SER439
F	SER439
H	SER439
J	SER439
L	SER439
N	SER439

site_id	SWS_FT_FI9
Number of Residues	7
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	GLU443
D	GLU443
F	GLU443
H	GLU443
J	GLU443
L	GLU443
N	GLU443

site_id	SWS_FT_FI10
Number of Residues	7
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:P68369

Chain	Residue	Details
B	GLU445
I	LYS324
K	LYS324
M	LYS324
D	GLU445
F	GLU445
H	GLU445
J	GLU445
L	GLU445
N	GLU445
G	LYS324

site_id	SWS_FT_FI11
Number of Residues	7
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250\|UniProtKB:Q71U36

Chain	Residue	Details
B	TYR451
D	TYR451
F	TYR451
H	TYR451
J	TYR451
L	TYR451
N	TYR451

site_id	SWS_FT_FI12
Number of Residues	21
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	LYS326
H	LYS326
H	LYS370
J	LYS326
J	LYS370
L	LYS326
L	LYS370
N	LYS326
N	LYS370
B	LYS370
D	LYS326
D	LYS370
F	LYS326
F	LYS370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)