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7PCH

Human carboxyhemoglobin bound to Staphylococcus aureus hemophore IsdB - 1:2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005344molecular_functionoxygen carrier activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0005833cellular_componenthemoglobin complex
A0015670biological_processcarbon dioxide transport
A0015671biological_processoxygen transport
A0016020cellular_componentmembrane
A0019825molecular_functionoxygen binding
A0020037molecular_functionheme binding
A0030185biological_processnitric oxide transport
A0031720molecular_functionhaptoglobin binding
A0031838cellular_componenthaptoglobin-hemoglobin complex
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0043177molecular_functionorganic acid binding
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0071682cellular_componentendocytic vesicle lumen
A0072562cellular_componentblood microparticle
A0098869biological_processcellular oxidant detoxification
B0004601molecular_functionperoxidase activity
B0005344molecular_functionoxygen carrier activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0005833cellular_componenthemoglobin complex
B0008217biological_processregulation of blood pressure
B0015670biological_processcarbon dioxide transport
B0015671biological_processoxygen transport
B0019825molecular_functionoxygen binding
B0020037molecular_functionheme binding
B0030185biological_processnitric oxide transport
B0030492molecular_functionhemoglobin binding
B0031720molecular_functionhaptoglobin binding
B0031721molecular_functionhemoglobin alpha binding
B0031838cellular_componenthaptoglobin-hemoglobin complex
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0043177molecular_functionorganic acid binding
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0070293biological_processrenal absorption
B0070527biological_processplatelet aggregation
B0071682cellular_componentendocytic vesicle lumen
B0072562cellular_componentblood microparticle
B0097746biological_processblood vessel diameter maintenance
B0098869biological_processcellular oxidant detoxification
B1904724cellular_componenttertiary granule lumen
B1904813cellular_componentficolin-1-rich granule lumen
C0004601molecular_functionperoxidase activity
C0005344molecular_functionoxygen carrier activity
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005829cellular_componentcytosol
C0005833cellular_componenthemoglobin complex
C0015670biological_processcarbon dioxide transport
C0015671biological_processoxygen transport
C0016020cellular_componentmembrane
C0019825molecular_functionoxygen binding
C0020037molecular_functionheme binding
C0030185biological_processnitric oxide transport
C0031720molecular_functionhaptoglobin binding
C0031838cellular_componenthaptoglobin-hemoglobin complex
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0043177molecular_functionorganic acid binding
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0071682cellular_componentendocytic vesicle lumen
C0072562cellular_componentblood microparticle
C0098869biological_processcellular oxidant detoxification
D0004601molecular_functionperoxidase activity
D0005344molecular_functionoxygen carrier activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005829cellular_componentcytosol
D0005833cellular_componenthemoglobin complex
D0008217biological_processregulation of blood pressure
D0015670biological_processcarbon dioxide transport
D0015671biological_processoxygen transport
D0019825molecular_functionoxygen binding
D0020037molecular_functionheme binding
D0030185biological_processnitric oxide transport
D0030492molecular_functionhemoglobin binding
D0031720molecular_functionhaptoglobin binding
D0031721molecular_functionhemoglobin alpha binding
D0031838cellular_componenthaptoglobin-hemoglobin complex
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0043177molecular_functionorganic acid binding
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0070293biological_processrenal absorption
D0070527biological_processplatelet aggregation
D0071682cellular_componentendocytic vesicle lumen
D0072562cellular_componentblood microparticle
D0097746biological_processblood vessel diameter maintenance
D0098869biological_processcellular oxidant detoxification
D1904724cellular_componenttertiary granule lumen
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:Q7A656
ChainResidueDetails
EMET362
ETYR440
FMET362
FTYR440
DVAL1
DHIS2
DLYS82
DHIS143

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: distal binding residue
ChainResidueDetails
BHIS63
DHIS63

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: proximal binding residue
ChainResidueDetails
BHIS92
ALEU91
ALEU106
ATHR108
AVAL121
ASER133
CTHR8
CALA13
CTYR24
CLEU29
CHIS45
DHIS92
CASP47
CSER52
CVAL55
CGLY59
CLEU91
CLEU106
CTHR108
CVAL121
CSER133
ATYR24
ALEU29
AHIS45
AASP47
ASER52
AVAL55
AGLY59

site_idSWS_FT_FI4
Number of Residues38
DetailsSITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
ChainResidueDetails
BGLU7
BGLY74
BTHR84
BHIS92
BARG104
BLEU110
BGLY119
BPHE122
BALA128
BALA140
BLYS144
BGLY25
DGLU7
DGLY25
DGLY29
DTYR35
DTRP37
DPHE45
DASP52
DGLY56
DPHE71
DGLY74
BGLY29
DTHR84
DHIS92
DARG104
DLEU110
DGLY119
DPHE122
DALA128
DALA140
DLYS144
BTYR35
BTRP37
BPHE45
BASP52
BGLY56
BPHE71

site_idSWS_FT_FI5
Number of Residues6
DetailsSITE: Not glycated => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS59
BLYS82
BLYS95
DLYS59
DLYS82
DLYS95

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b
ChainResidueDetails
BVAL1
DVAL1
ALYS40
CLYS7
CLYS16
CLYS40

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER9
BSER44
DSER9
DSER44

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR12
BTHR50
BTHR87
DTHR12
DTHR50
DTHR87

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009
ChainResidueDetails
BLYS59
BLYS82
DLYS59
DLYS82

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
ChainResidueDetails
BCYS93
DCYS93
ASER131
ASER138
CSER102
CSER124
CSER131
CSER138

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
ChainResidueDetails
BLYS144
DLYS144
ATHR137
CTHR108
CTHR134
CTHR137

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
ChainResidueDetails
BVAL1
DVAL1
ALYS40
CLYS7
CLYS16
CLYS40

site_idSWS_FT_FI13
Number of Residues8
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS8
BLYS17
BLYS66
BLYS120
DLYS8
DLYS17
DLYS66
DLYS120

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
ChainResidueDetails
BLYS144
DLYS144

218853

PDB entries from 2024-04-24

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