Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004890 | molecular_function | GABA-A receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0004890 | molecular_function | GABA-A receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042597 | cellular_component | periplasmic space |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0004890 | molecular_function | GABA-A receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0020037 | molecular_function | heme binding |
| C | 0022900 | biological_process | electron transport chain |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042597 | cellular_component | periplasmic space |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0004890 | molecular_function | GABA-A receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0004890 | molecular_function | GABA-A receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0009055 | molecular_function | electron transfer activity |
| E | 0016020 | cellular_component | membrane |
| E | 0020037 | molecular_function | heme binding |
| E | 0022900 | biological_process | electron transport chain |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0042597 | cellular_component | periplasmic space |
| K | 0005576 | cellular_component | extracellular region |
| K | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| K | 0035821 | biological_process | modulation of process of another organism |
| K | 0090729 | molecular_function | toxin activity |
| K | 0099106 | molecular_function | ion channel regulator activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0030550 | molecular_function | acetylcholine receptor inhibitor activity |
| L | 0035821 | biological_process | modulation of process of another organism |
| L | 0090729 | molecular_function | toxin activity |
| L | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC |
| Chain | Residue | Details |
| B | CYS136-CYS150 | |
| A | CYS139-CYS153 | |
| D | CYS139-CYS153 |
| site_id | PS00272 |
| Number of Residues | 21 |
| Details | SNAKE_TOXIN Snake toxins signature. GCaatCPtvktgvdiq.CCstD |
| Chain | Residue | Details |
| K | GLY40-ASP60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Binds to Torpedo AChR => ECO:0000269|PubMed:10574958 |
| Chain | Residue | Details |
| K | LYS23 | |
| E | SER247-HIS267 | |
| E | ALA280-ASN303 | |
| E | ILE423-TYR445 | |
| K | LYS49 | |
| L | LYS23 | |
| L | LYS49 | |
| C | ILE222-ILE242 | |
| C | SER247-HIS267 | |
| C | ALA280-ASN303 | |
| C | ILE423-TYR445 | |
| E | ILE222-ILE242 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927 |
| Chain | Residue | Details |
| K | TRP25 | |
| L | PHE65 | |
| K | ASP27 | |
| K | PHE29 | |
| K | ARG33 | |
| K | PHE65 | |
| L | TRP25 | |
| L | ASP27 | |
| L | PHE29 | |
| L | ARG33 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Binds to alpha-7/CHRNA7 AChR => ECO:0000269|PubMed:10852927 |
| Chain | Residue | Details |
| K | ALA28 | |
| K | LYS35 | |
| L | ALA28 | |
| L | LYS35 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Binds to both neuronal alpha-7/CHRNA7 and Torpedo AChRs, may be important for inhibition of GABA(A) receptors => ECO:0000269|PubMed:10574958, ECO:0000269|PubMed:10852927, ECO:0000305|PubMed:26221036 |
| Chain | Residue | Details |
| K | ARG36 | |
| L | ARG36 | |
| E | TYR446-ASN448 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62813 |
| Chain | Residue | Details |
| D | THR130 | |
| B | PHE200 | |
| C | ASP95 | |
| C | PHE200 | |
| E | ASP95 | |
| E | PHE200 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30266951 |
| Chain | Residue | Details |
| D | TRP246 | |
| B | SER156 | |
| B | THR202 | |
| C | TYR97 | |
| C | SER156 | |
| C | THR202 | |
| E | TYR97 | |
| E | SER156 | |
| E | THR202 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN11 | |
| C | GLU155 | |
| E | GLU155 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U, ECO:0007744|PDB:6I53 |
| Chain | Residue | Details |
| D | ASN111 | |
| C | TYR157 | |
| E | TYR157 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN8 | |
| C | ASN8 | |
| E | ASN8 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN80 | |
| C | ASN80 | |
| E | ASN80 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN149 | |
| C | ASN149 | |
| E | ASN149 |
