7P47
Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000724 | biological_process | double-strand break repair via homologous recombination |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0019789 | molecular_function | SUMO transferase activity |
| A | 0030915 | cellular_component | Smc5-Smc6 complex |
| C | 0000022 | biological_process | mitotic spindle elongation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000794 | cellular_component | condensed nuclear chromosome |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005694 | cellular_component | chromosome |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016925 | biological_process | protein sumoylation |
| C | 0019789 | molecular_function | SUMO transferase activity |
| C | 0051301 | biological_process | cell division |
| C | 0061656 | molecular_function | SUMO conjugating enzyme activity |
| D | 0000794 | cellular_component | condensed nuclear chromosome |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005940 | cellular_component | septin ring |
| D | 0016925 | biological_process | protein sumoylation |
| D | 0031386 | molecular_function | protein tag activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
| E | 0000794 | cellular_component | condensed nuclear chromosome |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005940 | cellular_component | septin ring |
| E | 0016925 | biological_process | protein sumoylation |
| E | 0031386 | molecular_function | protein tag activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
Functional Information from PROSITE/UniProt
| site_id | PS00183 |
| Number of Residues | 16 |
| Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVyps.GtICLsiL |
| Chain | Residue | Details |
| C | TYR82-LEU97 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 153 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 87 |
| Details | Zinc finger: {"description":"SP-RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00452","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00452","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)"} |
| Chain | Residue | Details |
