7OTC
Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 0 | 0003735 | molecular_function | structural constituent of ribosome |
| 0 | 0006412 | biological_process | translation |
| 0 | 0015934 | cellular_component | large ribosomal subunit |
| 1 | 0003735 | molecular_function | structural constituent of ribosome |
| 1 | 0005840 | cellular_component | ribosome |
| 1 | 0006412 | biological_process | translation |
| 2 | 0003735 | molecular_function | structural constituent of ribosome |
| 2 | 0005840 | cellular_component | ribosome |
| 2 | 0006412 | biological_process | translation |
| 3 | 0003735 | molecular_function | structural constituent of ribosome |
| 3 | 0005840 | cellular_component | ribosome |
| 3 | 0006412 | biological_process | translation |
| 4 | 0003735 | molecular_function | structural constituent of ribosome |
| 4 | 0005840 | cellular_component | ribosome |
| 4 | 0006412 | biological_process | translation |
| 5 | 0003735 | molecular_function | structural constituent of ribosome |
| 5 | 0005840 | cellular_component | ribosome |
| 5 | 0006412 | biological_process | translation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003735 | molecular_function | structural constituent of ribosome |
| C | 0005840 | cellular_component | ribosome |
| C | 0006412 | biological_process | translation |
| C | 0015934 | cellular_component | large ribosomal subunit |
| C | 0016740 | molecular_function | transferase activity |
| D | 0003735 | molecular_function | structural constituent of ribosome |
| D | 0005840 | cellular_component | ribosome |
| D | 0006412 | biological_process | translation |
| E | 0003735 | molecular_function | structural constituent of ribosome |
| E | 0005840 | cellular_component | ribosome |
| E | 0006412 | biological_process | translation |
| F | 0003735 | molecular_function | structural constituent of ribosome |
| F | 0005840 | cellular_component | ribosome |
| F | 0006412 | biological_process | translation |
| G | 0003735 | molecular_function | structural constituent of ribosome |
| G | 0005840 | cellular_component | ribosome |
| G | 0006412 | biological_process | translation |
| G | 0019843 | molecular_function | rRNA binding |
| J | 0003735 | molecular_function | structural constituent of ribosome |
| J | 0005840 | cellular_component | ribosome |
| J | 0006412 | biological_process | translation |
| K | 0003735 | molecular_function | structural constituent of ribosome |
| K | 0005840 | cellular_component | ribosome |
| K | 0006412 | biological_process | translation |
| K | 0015934 | cellular_component | large ribosomal subunit |
| L | 0003735 | molecular_function | structural constituent of ribosome |
| L | 0005840 | cellular_component | ribosome |
| L | 0006412 | biological_process | translation |
| L | 0015934 | cellular_component | large ribosomal subunit |
| M | 0003735 | molecular_function | structural constituent of ribosome |
| M | 0005840 | cellular_component | ribosome |
| M | 0006412 | biological_process | translation |
| M | 0019843 | molecular_function | rRNA binding |
| N | 0003735 | molecular_function | structural constituent of ribosome |
| N | 0005840 | cellular_component | ribosome |
| N | 0006412 | biological_process | translation |
| O | 0003735 | molecular_function | structural constituent of ribosome |
| O | 0005840 | cellular_component | ribosome |
| O | 0006412 | biological_process | translation |
| P | 0003735 | molecular_function | structural constituent of ribosome |
| P | 0005840 | cellular_component | ribosome |
| P | 0006412 | biological_process | translation |
| Q | 0003735 | molecular_function | structural constituent of ribosome |
| Q | 0005840 | cellular_component | ribosome |
| Q | 0006412 | biological_process | translation |
| Q | 0019843 | molecular_function | rRNA binding |
| R | 0003723 | molecular_function | RNA binding |
| R | 0003735 | molecular_function | structural constituent of ribosome |
| R | 0005840 | cellular_component | ribosome |
| R | 0006412 | biological_process | translation |
| S | 0003735 | molecular_function | structural constituent of ribosome |
| S | 0005840 | cellular_component | ribosome |
| S | 0006412 | biological_process | translation |
| S | 0015934 | cellular_component | large ribosomal subunit |
| T | 0003735 | molecular_function | structural constituent of ribosome |
| T | 0005840 | cellular_component | ribosome |
| T | 0006412 | biological_process | translation |
| U | 0003723 | molecular_function | RNA binding |
| U | 0003735 | molecular_function | structural constituent of ribosome |
| U | 0005840 | cellular_component | ribosome |
| U | 0006412 | biological_process | translation |
| V | 0003735 | molecular_function | structural constituent of ribosome |
| V | 0005840 | cellular_component | ribosome |
| V | 0006412 | biological_process | translation |
| V | 0008097 | molecular_function | 5S rRNA binding |
| W | 0003735 | molecular_function | structural constituent of ribosome |
| W | 0005840 | cellular_component | ribosome |
| W | 0006412 | biological_process | translation |
| X | 0003735 | molecular_function | structural constituent of ribosome |
| X | 0005840 | cellular_component | ribosome |
| X | 0006412 | biological_process | translation |
| Y | 0003735 | molecular_function | structural constituent of ribosome |
| Y | 0005840 | cellular_component | ribosome |
| Y | 0006412 | biological_process | translation |
| Z | 0003735 | molecular_function | structural constituent of ribosome |
| Z | 0006412 | biological_process | translation |
| Z | 0015934 | cellular_component | large ribosomal subunit |
| b | 0003735 | molecular_function | structural constituent of ribosome |
| b | 0005840 | cellular_component | ribosome |
| b | 0006412 | biological_process | translation |
| b | 0015935 | cellular_component | small ribosomal subunit |
| c | 0003676 | molecular_function | nucleic acid binding |
| c | 0003723 | molecular_function | RNA binding |
| c | 0003735 | molecular_function | structural constituent of ribosome |
| c | 0006412 | biological_process | translation |
| d | 0003723 | molecular_function | RNA binding |
| d | 0003735 | molecular_function | structural constituent of ribosome |
| d | 0006412 | biological_process | translation |
| d | 0015935 | cellular_component | small ribosomal subunit |
| d | 0019843 | molecular_function | rRNA binding |
| e | 0003723 | molecular_function | RNA binding |
| e | 0003735 | molecular_function | structural constituent of ribosome |
| e | 0005840 | cellular_component | ribosome |
| e | 0006412 | biological_process | translation |
| e | 0015935 | cellular_component | small ribosomal subunit |
| f | 0003735 | molecular_function | structural constituent of ribosome |
| f | 0005840 | cellular_component | ribosome |
| f | 0006412 | biological_process | translation |
| f | 0019843 | molecular_function | rRNA binding |
| g | 0003723 | molecular_function | RNA binding |
| g | 0003735 | molecular_function | structural constituent of ribosome |
| g | 0006412 | biological_process | translation |
| g | 0015935 | cellular_component | small ribosomal subunit |
| h | 0003735 | molecular_function | structural constituent of ribosome |
| h | 0005840 | cellular_component | ribosome |
| h | 0006412 | biological_process | translation |
| i | 0003735 | molecular_function | structural constituent of ribosome |
| i | 0005840 | cellular_component | ribosome |
| i | 0006412 | biological_process | translation |
| j | 0003723 | molecular_function | RNA binding |
| j | 0003735 | molecular_function | structural constituent of ribosome |
| j | 0005840 | cellular_component | ribosome |
| j | 0006412 | biological_process | translation |
| k | 0003735 | molecular_function | structural constituent of ribosome |
| k | 0005840 | cellular_component | ribosome |
| k | 0006412 | biological_process | translation |
| l | 0003735 | molecular_function | structural constituent of ribosome |
| l | 0005840 | cellular_component | ribosome |
| l | 0006412 | biological_process | translation |
| l | 0015935 | cellular_component | small ribosomal subunit |
| m | 0003676 | molecular_function | nucleic acid binding |
| m | 0003723 | molecular_function | RNA binding |
| m | 0003735 | molecular_function | structural constituent of ribosome |
| m | 0005840 | cellular_component | ribosome |
| m | 0006412 | biological_process | translation |
| n | 0003735 | molecular_function | structural constituent of ribosome |
| n | 0005840 | cellular_component | ribosome |
| n | 0006412 | biological_process | translation |
| o | 0003735 | molecular_function | structural constituent of ribosome |
| o | 0005840 | cellular_component | ribosome |
| o | 0006412 | biological_process | translation |
| p | 0003735 | molecular_function | structural constituent of ribosome |
| p | 0005840 | cellular_component | ribosome |
| p | 0006412 | biological_process | translation |
| q | 0003735 | molecular_function | structural constituent of ribosome |
| q | 0005840 | cellular_component | ribosome |
| q | 0006412 | biological_process | translation |
| r | 0003735 | molecular_function | structural constituent of ribosome |
| r | 0005840 | cellular_component | ribosome |
| r | 0006412 | biological_process | translation |
| s | 0003723 | molecular_function | RNA binding |
| s | 0003735 | molecular_function | structural constituent of ribosome |
| s | 0005840 | cellular_component | ribosome |
| s | 0006412 | biological_process | translation |
| s | 0015935 | cellular_component | small ribosomal subunit |
| t | 0003723 | molecular_function | RNA binding |
| t | 0003735 | molecular_function | structural constituent of ribosome |
| t | 0005840 | cellular_component | ribosome |
| t | 0006412 | biological_process | translation |
| u | 0003735 | molecular_function | structural constituent of ribosome |
| u | 0005840 | cellular_component | ribosome |
| u | 0006412 | biological_process | translation |
| w | 0003746 | molecular_function | translation elongation factor activity |
| w | 0003924 | molecular_function | GTPase activity |
| w | 0005525 | molecular_function | GTP binding |
| w | 0006414 | biological_process | translational elongation |
Functional Information from PROSITE/UniProt
| site_id | PS00049 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtkkgvrrp.DGsvirFdgNacVL |
| Chain | Residue | Details |
| K | ALA60-LEU86 |
| site_id | PS00052 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_S7 Ribosomal protein S7 signature. SeLlakFVnilmvdGKKstaesIVysA |
| Chain | Residue | Details |
| g | SER20-ALA46 |
| site_id | PS00053 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_S8 Ribosomal protein S8 signature. GiaVVSTSkGVMtdraAR |
| Chain | Residue | Details |
| h | GLY100-ARG117 |
| site_id | PS00054 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S11 Ribosomal protein S11 signature. IrALnaA.GFrItnitDvTPiPHN |
| Chain | Residue | Details |
| k | ILE97-ASN119 |
| site_id | PS00055 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAlR |
| Chain | Residue | Details |
| l | LYS43-ARG50 |
| site_id | PS00056 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S17 Ribosomal protein S17 signature. GDvVeIrEcRPLS |
| Chain | Residue | Details |
| q | GLY56-SER68 |
| site_id | PS00057 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_S18 Ribosomal protein S18 signature. IDYkd.IatLknYITEs.GKIvpsRI |
| Chain | Residue | Details |
| r | ILE21-ILE44 |
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. PdhkhavialTsiYGVGKTRSkAILaAAG |
| Chain | Residue | Details |
| m | PRO10-GLY38 |
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DWmeqEQeRGITItsA |
| Chain | Residue | Details |
| w | ASP51-ALA66 |
| site_id | PS00323 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S19 Ribosomal protein S19 signature. NGRqhvpvfVtdemVGhkLGEFapT |
| Chain | Residue | Details |
| s | ASN53-THR77 |
| site_id | PS00358 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L5 Ribosomal protein L5 signature. LaaISGQkpLiTkARkS |
| Chain | Residue | Details |
| F | LEU57-SER73 |
| site_id | PS00360 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGisGQagAirhGiTRAL |
| Chain | Residue | Details |
| i | GLY69-LEU87 |
| site_id | PS00361 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_S10 Ribosomal protein S10 signature. AkrtGAqvrGPIpLPT |
| Chain | Residue | Details |
| j | ALA29-THR44 |
| site_id | PS00362 |
| Number of Residues | 31 |
| Details | RIBOSOMAL_S15 Ribosomal protein S15 signature. LqgHFaehKkDhhSrrgLlrMvsqrrkLldY |
| Chain | Residue | Details |
| o | LEU39-TYR69 |
| site_id | PS00430 |
| Number of Residues | 66 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mireerllkvlraphvsekastameksntivlkvakdatkaeikaavqklfevevevv.........................................................NTLVVKGK |
| Chain | Residue | Details |
| T | MET1-LYS66 |
| site_id | PS00464 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L22 Ribosomal protein L22 signature. KriMpRAkGRadrilkrtSHITVvV |
| Chain | Residue | Details |
| S | LYS83-VAL107 |
| site_id | PS00467 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGTAmNPvD |
| Chain | Residue | Details |
| C | PRO218-ASP229 |
| site_id | PS00474 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L3 Ribosomal protein L3 signature. FadvkkvDvtGtSkGKGfaGtvkR |
| Chain | Residue | Details |
| D | PHE101-ARG124 |
| site_id | PS00475 |
| Number of Residues | 31 |
| Details | RIBOSOMAL_L15 Ribosomal protein L15 signature. KVILaGeVttp..VtVrglrVTkgAraaIeaaG |
| Chain | Residue | Details |
| L | LYS109-GLY139 |
| site_id | PS00525 |
| Number of Residues | 9 |
| Details | RIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGV |
| Chain | Residue | Details |
| G | PRO154-VAL162 |
| site_id | PS00527 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S14 Ribosomal protein S14 signature. R.CrqtgrphgflrkFGLSRiKVR |
| Chain | Residue | Details |
| n | ARG63-ARG85 |
| site_id | PS00548 |
| Number of Residues | 35 |
| Details | RIBOSOMAL_S3 Ribosomal protein S3 signature. ARtewyreGrVplHt..LradIDyntseahTtyGviG |
| Chain | Residue | Details |
| c | ALA163-GLY197 |
| site_id | PS00579 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L29 Ribosomal protein L29 signature. QSHLLKqVRRDVARV |
| Chain | Residue | Details |
| Y | GLN39-VAL53 |
| site_id | PS00582 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNkrtkPekLElkKFD |
| Chain | Residue | Details |
| 1 | TYR21-ASP40 |
| site_id | PS00585 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_S5 Ribosomal protein S5 signature. GRifsFtAltVVGDgn.GrVGfGygkar.EVpa.AI |
| Chain | Residue | Details |
| e | GLY28-ILE60 |
| site_id | PS00586 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRqGKIWIRVFP |
| Chain | Residue | Details |
| M | LYS58-PRO69 |
| site_id | PS00632 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S4 Ribosomal protein S4 signature. LEgRLdnvVYRmgfGaTraeARqLV |
| Chain | Residue | Details |
| d | LEU94-VAL118 |
| site_id | PS00634 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_L30 Ribosomal protein L30 signature. TLlgLgLrRigHtVeredtpairgMInaVsfMV |
| Chain | Residue | Details |
| Z | THR23-VAL55 |
| site_id | PS00646 |
| Number of Residues | 14 |
| Details | RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHrrGlpVRGQ |
| Chain | Residue | Details |
| m | ARG87-GLN100 |
| site_id | PS00732 |
| Number of Residues | 10 |
| Details | RIBOSOMAL_S16 Ribosomal protein S16 signature. VtIRLARHGA |
| Chain | Residue | Details |
| p | VAL2-ALA11 |
| site_id | PS00783 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_L13 Ribosomal protein L13 signature. VKGMLPkgpl.GRamfrkLkVYaG |
| Chain | Residue | Details |
| J | VAL105-GLY127 |
| site_id | PS00784 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsvlkRnrsh.GFraR |
| Chain | Residue | Details |
| 2 | LYS2-ARG21 |
| site_id | PS00828 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L36 Ribosomal protein L36 signature. CrnCkiVkRdgvIrViCsaepKHkQrQ |
| Chain | Residue | Details |
| 4 | CYS11-GLN37 |
| site_id | PS00831 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L27 Ribosomal protein L27 signature. GsIIvRQRGtkfhaG |
| Chain | Residue | Details |
| W | GLY34-GLY48 |
| site_id | PS00936 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L35 Ribosomal protein L35 signature. KTVrGAaKRFkktgkggfkhkhanl.RH |
| Chain | Residue | Details |
| 3 | LYS5-HIS31 |
| site_id | PS00937 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L20 Ribosomal protein L20 signature. KrqfRqLWIARINaaaR |
| Chain | Residue | Details |
| Q | LYS54-ARG70 |
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. MrDMLKAGVHFG |
| Chain | Residue | Details |
| b | MET6-GLY17 |
| site_id | PS00963 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PdaLFViDadhEhiaIkEannlGIP |
| Chain | Residue | Details |
| b | PRO158-PRO182 |
| site_id | PS01015 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGAVR.KAKLYYLR |
| Chain | Residue | Details |
| P | VAL86-ARG101 |
| site_id | PS01048 |
| Number of Residues | 10 |
| Details | RIBOSOMAL_S6 Ribosomal protein S6 signature. GrRQLAYpIN |
| Chain | Residue | Details |
| f | GLY43-ASN52 |
| site_id | PS01108 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeViVLtGkdKGkr.GkV |
| Chain | Residue | Details |
| U | ASP8-VAL25 |
| site_id | PS01143 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L31 Ribosomal protein L31 signature. DVcskcHPFFTgkqrdvatg....GR |
| Chain | Residue | Details |
| 5 | ASP35-ARG56 |
| site_id | PS01167 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_L17 Ribosomal protein L17 signature. IkTTlpKaKelrrvvEpLITlAK |
| Chain | Residue | Details |
| N | ILE34-LYS56 |
| site_id | PS01169 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_L21 Ribosomal protein L21 signature. VkivKfrrRKhyrkqqGHRQwfT |
| Chain | Residue | Details |
| R | VAL72-THR94 |
| site_id | PS01181 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S21 Ribosomal protein S21 signature. DvALRRFKRsceK |
| Chain | Residue | Details |
| u | ASP13-LYS25 |
