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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7OQY

Cryo-EM structure of the cellular negative regulator TFS4 bound to the archaeal RNA polymerase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0008270molecular_functionzinc ion binding
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034062molecular_function5'-3' RNA polymerase activity
A0046872molecular_functionmetal ion binding
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0005737cellular_componentcytoplasm
B0006351biological_processDNA-templated transcription
B0008270molecular_functionzinc ion binding
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0046872molecular_functionmetal ion binding
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0005737cellular_componentcytoplasm
C0006351biological_processDNA-templated transcription
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0034062molecular_function5'-3' RNA polymerase activity
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0005737cellular_componentcytoplasm
D0006351biological_processDNA-templated transcription
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0034062molecular_function5'-3' RNA polymerase activity
D0046872molecular_functionmetal ion binding
D0046983molecular_functionprotein dimerization activity
D0051536molecular_functioniron-sulfur cluster binding
D0051538molecular_function3 iron, 4 sulfur cluster binding
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003676molecular_functionnucleic acid binding
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0005737cellular_componentcytoplasm
E0006351biological_processDNA-templated transcription
E0006352biological_processDNA-templated transcription initiation
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
F0000166molecular_functionnucleotide binding
F0000428cellular_componentDNA-directed RNA polymerase complex
F0003899molecular_functionDNA-directed RNA polymerase activity
F0005737cellular_componentcytoplasm
F0006351biological_processDNA-templated transcription
F0006352biological_processDNA-templated transcription initiation
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0030880cellular_componentRNA polymerase complex
F0034062molecular_function5'-3' RNA polymerase activity
G0000428cellular_componentDNA-directed RNA polymerase complex
G0003899molecular_functionDNA-directed RNA polymerase activity
G0005737cellular_componentcytoplasm
G0006351biological_processDNA-templated transcription
G0016740molecular_functiontransferase activity
G0016779molecular_functionnucleotidyltransferase activity
G0034062molecular_function5'-3' RNA polymerase activity
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed RNA polymerase activity
H0005737cellular_componentcytoplasm
H0006351biological_processDNA-templated transcription
H0006362biological_processtranscription elongation by RNA polymerase I
H0006366biological_processtranscription by RNA polymerase II
H0016740molecular_functiontransferase activity
H0016779molecular_functionnucleotidyltransferase activity
H0034062molecular_function5'-3' RNA polymerase activity
H0042797biological_processtRNA transcription by RNA polymerase III
K0000428cellular_componentDNA-directed RNA polymerase complex
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0005737cellular_componentcytoplasm
K0006351biological_processDNA-templated transcription
K0006360biological_processtranscription by RNA polymerase I
K0006366biological_processtranscription by RNA polymerase II
K0016740molecular_functiontransferase activity
K0016779molecular_functionnucleotidyltransferase activity
K0034062molecular_function5'-3' RNA polymerase activity
K0042797biological_processtRNA transcription by RNA polymerase III
L0000428cellular_componentDNA-directed RNA polymerase complex
L0003677molecular_functionDNA binding
L0003899molecular_functionDNA-directed RNA polymerase activity
L0005737cellular_componentcytoplasm
L0006351biological_processDNA-templated transcription
L0016740molecular_functiontransferase activity
L0016779molecular_functionnucleotidyltransferase activity
L0034062molecular_function5'-3' RNA polymerase activity
L0046983molecular_functionprotein dimerization activity
N0000428cellular_componentDNA-directed RNA polymerase complex
N0003677molecular_functionDNA binding
N0003899molecular_functionDNA-directed RNA polymerase activity
N0005737cellular_componentcytoplasm
N0006351biological_processDNA-templated transcription
N0008270molecular_functionzinc ion binding
N0016740molecular_functiontransferase activity
N0016779molecular_functionnucleotidyltransferase activity
N0034062molecular_function5'-3' RNA polymerase activity
N0046872molecular_functionmetal ion binding
P0000428cellular_componentDNA-directed RNA polymerase complex
P0003677molecular_functionDNA binding
P0003899molecular_functionDNA-directed RNA polymerase activity
P0005737cellular_componentcytoplasm
P0006351biological_processDNA-templated transcription
P0008270molecular_functionzinc ion binding
P0016740molecular_functiontransferase activity
P0016779molecular_functionnucleotidyltransferase activity
P0034062molecular_function5'-3' RNA polymerase activity
P0046872molecular_functionmetal ion binding
Q0000428cellular_componentDNA-directed RNA polymerase complex
Q0003677molecular_functionDNA binding
Q0003899molecular_functionDNA-directed RNA polymerase activity
Q0005737cellular_componentcytoplasm
Q0006351biological_processDNA-templated transcription
Q0016740molecular_functiontransferase activity
Q0016779molecular_functionnucleotidyltransferase activity
Y0000428cellular_componentDNA-directed RNA polymerase complex
Y0003899molecular_functionDNA-directed RNA polymerase activity
Y0006351biological_processDNA-templated transcription
Y0045892biological_processnegative regulation of DNA-templated transcription
Y0046872molecular_functionmetal ion binding
Y0051607biological_processdefense response to virus
Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SyslktieehFvpYSIAKKYIkELIdTGS
ChainResidueDetails
FSER2-SER30
site_idPS00446
Number of Residues41
DetailsRNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRasilyvpvmAvdeVyfieNnSplyDEiLAhRLALVP
ChainResidueDetails
DASN26-PRO66
site_idPS01030
Number of Residues21
DetailsRNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCPKCGSFLkvkgnkmv......CskC
ChainResidueDetails
YPHE3-CYS23
site_idPS01110
Number of Residues14
DetailsRNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHeiLqlEE
ChainResidueDetails
HHIS14-GLU27
site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYEiARiISaRAlQ
ChainResidueDetails
KTHR19-GLN33
site_idPS01112
Number of Residues10
DetailsRNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPIrCFTCG
ChainResidueDetails
NILE2-GLY11
site_idPS01154
Number of Residues32
DetailsRNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. IdgEeHTIgNlLkgmLlkvpgVkfaaYslpHP
ChainResidueDetails
LILE17-PRO48
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFATrHGQKGV
ChainResidueDetails
BGLY873-VAL885
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00863","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00863","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00320","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues82
DetailsDomain: {"description":"S1 motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00865","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00250","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00615","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OK0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQ4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues30
DetailsRegion: {"description":"ZR-N","evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29203770","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues24
DetailsRegion: {"description":"Flexible linker","evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues37
DetailsRegion: {"description":"ZR-C","evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29203770","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsActive site: {"evidences":[{"source":"PubMed","id":"29203770","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29203770","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34535646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29203770","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7OQY","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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