Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OP9

Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 2,6-dichloropurine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
G	0003824	molecular_function	catalytic activity
G	0004731	molecular_function	purine-nucleoside phosphorylase activity
G	0005829	cellular_component	cytosol
G	0006139	biological_process	nucleobase-containing compound metabolic process
G	0006152	biological_process	purine nucleoside catabolic process
G	0009116	biological_process	nucleoside metabolic process
G	0009164	biological_process	nucleoside catabolic process
G	0016757	molecular_function	glycosyltransferase activity
G	0016763	molecular_function	pentosyltransferase activity
H	0003824	molecular_function	catalytic activity
H	0004731	molecular_function	purine-nucleoside phosphorylase activity
H	0005829	cellular_component	cytosol
H	0006139	biological_process	nucleobase-containing compound metabolic process
H	0006152	biological_process	purine nucleoside catabolic process
H	0009116	biological_process	nucleoside metabolic process
H	0009164	biological_process	nucleoside catabolic process
H	0016757	molecular_function	glycosyltransferase activity
H	0016763	molecular_function	pentosyltransferase activity
I	0003824	molecular_function	catalytic activity
I	0004731	molecular_function	purine-nucleoside phosphorylase activity
I	0005829	cellular_component	cytosol
I	0006139	biological_process	nucleobase-containing compound metabolic process
I	0006152	biological_process	purine nucleoside catabolic process
I	0009116	biological_process	nucleoside metabolic process
I	0009164	biological_process	nucleoside catabolic process
I	0016757	molecular_function	glycosyltransferase activity
I	0016763	molecular_function	pentosyltransferase activity
J	0003824	molecular_function	catalytic activity
J	0004731	molecular_function	purine-nucleoside phosphorylase activity
J	0005829	cellular_component	cytosol
J	0006139	biological_process	nucleobase-containing compound metabolic process
J	0006152	biological_process	purine nucleoside catabolic process
J	0009116	biological_process	nucleoside metabolic process
J	0009164	biological_process	nucleoside catabolic process
J	0016757	molecular_function	glycosyltransferase activity
J	0016763	molecular_function	pentosyltransferase activity
K	0003824	molecular_function	catalytic activity
K	0004731	molecular_function	purine-nucleoside phosphorylase activity
K	0005829	cellular_component	cytosol
K	0006139	biological_process	nucleobase-containing compound metabolic process
K	0006152	biological_process	purine nucleoside catabolic process
K	0009116	biological_process	nucleoside metabolic process
K	0009164	biological_process	nucleoside catabolic process
K	0016757	molecular_function	glycosyltransferase activity
K	0016763	molecular_function	pentosyltransferase activity
L	0003824	molecular_function	catalytic activity
L	0004731	molecular_function	purine-nucleoside phosphorylase activity
L	0005829	cellular_component	cytosol
L	0006139	biological_process	nucleobase-containing compound metabolic process
L	0006152	biological_process	purine nucleoside catabolic process
L	0009116	biological_process	nucleoside metabolic process
L	0009164	biological_process	nucleoside catabolic process
L	0016757	molecular_function	glycosyltransferase activity
L	0016763	molecular_function	pentosyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiAScTIyvtEL

Chain	Residue	Details
A	GLY61-LEU76

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ASP204
J	ASP204
K	ASP204
L	ASP204
B	ASP204
C	ASP204
D	ASP204
E	ASP204
F	ASP204
G	ASP204
H	ASP204
I	ASP204

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P50389

Chain	Residue	Details
A	HIS4
E	ARG43
F	HIS4
F	ARG43
G	HIS4
G	ARG43
H	HIS4
H	ARG43
I	HIS4
I	ARG43
J	HIS4
A	ARG43
J	ARG43
K	HIS4
K	ARG43
L	HIS4
L	ARG43
B	HIS4
B	ARG43
C	HIS4
C	ARG43
D	HIS4
D	ARG43
E	HIS4

site_id	SWS_FT_FI3
Number of Residues	60
Details	BINDING: in other chain => ECO:0000250\|UniProtKB:P50389

Chain	Residue	Details
A	GLY20
B	SER203
C	GLY20
C	ARG24
C	ARG87
C	GLU179
C	SER203
D	GLY20
D	ARG24
D	ARG87
D	GLU179
A	ARG24
D	SER203
E	GLY20
E	ARG24
E	ARG87
E	GLU179
E	SER203
F	GLY20
F	ARG24
F	ARG87
F	GLU179
A	ARG87
F	SER203
G	GLY20
G	ARG24
G	ARG87
G	GLU179
G	SER203
H	GLY20
H	ARG24
H	ARG87
H	GLU179
A	GLU179
H	SER203
I	GLY20
I	ARG24
I	ARG87
I	GLU179
I	SER203
J	GLY20
J	ARG24
J	ARG87
J	GLU179
A	SER203
J	SER203
K	GLY20
K	ARG24
K	ARG87
K	GLU179
K	SER203
L	GLY20
L	ARG24
L	ARG87
L	GLU179
B	GLY20
L	SER203
B	ARG24
B	ARG87
B	GLU179

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Important for catalytic activity => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ARG217
J	ARG217
K	ARG217
L	ARG217
B	ARG217
C	ARG217
D	ARG217
E	ARG217
F	ARG217
G	ARG217
H	ARG217
I	ARG217

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)