7OLI
Crystal structure of Pab-AGOG in complex with 8-oxoguanosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000702 | molecular_function | oxidized base lesion DNA N-glycosylase activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| A | 0006281 | biological_process | DNA repair |
| A | 0006284 | biological_process | base-excision repair |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0016829 | molecular_function | lyase activity |
| A | 0140078 | molecular_function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| B | 0000702 | molecular_function | oxidized base lesion DNA N-glycosylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| B | 0006281 | biological_process | DNA repair |
| B | 0006284 | biological_process | base-excision repair |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0016829 | molecular_function | lyase activity |
| B | 0140078 | molecular_function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 8HG A 301 |
| Chain | Residue |
| A | GLN24 |
| A | ASP208 |
| A | TRP212 |
| A | HOH449 |
| A | HOH465 |
| A | HOH515 |
| A | SER51 |
| A | TYR52 |
| A | TRP62 |
| A | LYS142 |
| A | PHE146 |
| A | LYS149 |
| A | PRO172 |
| A | ASP174 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ARG15 |
| A | GLU19 |
| A | ARG156 |
| A | SER160 |
| A | THR161 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 8HG B 301 |
| Chain | Residue |
| B | GLN24 |
| B | SER51 |
| B | TYR52 |
| B | TRP62 |
| B | LYS142 |
| B | PHE146 |
| B | PRO172 |
| B | ASP174 |
| B | ASP208 |
| B | TRP212 |
| B | HOH435 |
| B | HOH474 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | GLU19 |
| B | ARG29 |
| B | GLU233 |
| B | LYS236 |
| B | HOH404 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | ARG15 |
| B | GLU19 |
| B | ARG156 |
| B | SER160 |
| B | THR161 |
| B | HOH445 |
| B | HOH521 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| B | LYS57 |
| B | GLY58 |
| B | ARG176 |
| B | HOH474 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| B | MET1 |
| B | ARG4 |
| B | ASN20 |
| B | SER222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Schiff-base intermediate with DNA => ECO:0000255|HAMAP-Rule:MF_01168 |
| Chain | Residue | Details |
| A | LYS142 | |
| B | LYS142 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01168 |
| Chain | Residue | Details |
| A | ASP174 | |
| B | ASP174 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01168 |
| Chain | Residue | Details |
| A | GLN24 | |
| B | TRP62 | |
| B | PHE146 | |
| B | PRO172 | |
| B | ASP208 | |
| B | TRP212 | |
| A | SER51 | |
| A | TRP62 | |
| A | PHE146 | |
| A | PRO172 | |
| A | ASP208 | |
| A | TRP212 | |
| B | GLN24 | |
| B | SER51 |
