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7OKX

Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite structure)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0005634cellular_componentnucleus
A0006351biological_processDNA-templated transcription
A0006366biological_processtranscription by RNA polymerase II
A0016779molecular_functionnucleotidyltransferase activity
A0031981cellular_componentnuclear lumen
A0032991cellular_componentprotein-containing complex
A0046872molecular_functionmetal ion binding
B0000428cellular_componentDNA-directed RNA polymerase complex
B0000781cellular_componentchromosome, telomeric region
B0001055molecular_functionRNA polymerase II activity
B0001172biological_processRNA-templated transcription
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005665cellular_componentRNA polymerase II, core complex
B0006351biological_processDNA-templated transcription
B0006366biological_processtranscription by RNA polymerase II
B0016779molecular_functionnucleotidyltransferase activity
B0032549molecular_functionribonucleoside binding
B0034062molecular_function5'-3' RNA polymerase activity
B0046872molecular_functionmetal ion binding
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005665cellular_componentRNA polymerase II, core complex
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006366biological_processtranscription by RNA polymerase II
C0046983molecular_functionprotein dimerization activity
D0000166molecular_functionnucleotide binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005665cellular_componentRNA polymerase II, core complex
D0005829cellular_componentcytosol
D0006352biological_processDNA-templated transcription initiation
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0016607cellular_componentnuclear speck
D0030880cellular_componentRNA polymerase complex
D0031369molecular_functiontranslation initiation factor binding
D0044237biological_processcellular metabolic process
E0001054molecular_functionRNA polymerase I activity
E0001055molecular_functionRNA polymerase II activity
E0001056molecular_functionRNA polymerase III activity
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005665cellular_componentRNA polymerase II, core complex
E0005666cellular_componentRNA polymerase III complex
E0005736cellular_componentRNA polymerase I complex
E0006351biological_processDNA-templated transcription
E0006362biological_processtranscription elongation by RNA polymerase I
E0006366biological_processtranscription by RNA polymerase II
E0042797biological_processtRNA transcription by RNA polymerase III
F0000428cellular_componentDNA-directed RNA polymerase complex
F0001650cellular_componentfibrillar center
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005665cellular_componentRNA polymerase II, core complex
F0005666cellular_componentRNA polymerase III complex
F0005736cellular_componentRNA polymerase I complex
F0006351biological_processDNA-templated transcription
F0006366biological_processtranscription by RNA polymerase II
G0003676molecular_functionnucleic acid binding
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
H0005634cellular_componentnucleus
H0005665cellular_componentRNA polymerase II, core complex
H0006351biological_processDNA-templated transcription
I0000428cellular_componentDNA-directed RNA polymerase complex
I0001193biological_processmaintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I0003676molecular_functionnucleic acid binding
I0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005665cellular_componentRNA polymerase II, core complex
I0005730cellular_componentnucleolus
I0006283biological_processtranscription-coupled nucleotide-excision repair
I0006351biological_processDNA-templated transcription
I0006366biological_processtranscription by RNA polymerase II
I0006367biological_processtranscription initiation at RNA polymerase II promoter
I0008270molecular_functionzinc ion binding
I0046872molecular_functionmetal ion binding
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
J0006351biological_processDNA-templated transcription
J0008270molecular_functionzinc ion binding
J0046872molecular_functionmetal ion binding
K0000428cellular_componentDNA-directed RNA polymerase complex
K0001055molecular_functionRNA polymerase II activity
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
K0005634cellular_componentnucleus
K0005665cellular_componentRNA polymerase II, core complex
K0006351biological_processDNA-templated transcription
K0006366biological_processtranscription by RNA polymerase II
K0046983molecular_functionprotein dimerization activity
L0003677molecular_functionDNA binding
L0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
L0005634cellular_componentnucleus
L0005665cellular_componentRNA polymerase II, core complex
L0005666cellular_componentRNA polymerase III complex
L0005736cellular_componentRNA polymerase I complex
L0006351biological_processDNA-templated transcription
L0006366biological_processtranscription by RNA polymerase II
L0008270molecular_functionzinc ion binding
L0046872molecular_functionmetal ion binding
M0000987molecular_functioncis-regulatory region sequence-specific DNA binding
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0006366biological_processtranscription by RNA polymerase II
M0006368biological_processtranscription elongation by RNA polymerase II
M0008023cellular_componenttranscription elongation factor complex
M0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
M0042795biological_processsnRNA transcription by RNA polymerase II
O0003711molecular_functiontranscription elongation factor activity
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0006368biological_processtranscription elongation by RNA polymerase II
O0008023cellular_componenttranscription elongation factor complex
O0015030cellular_componentCajal body
O0016604cellular_componentnuclear body
O0016607cellular_componentnuclear speck
O0032783cellular_componentsuper elongation complex
O0034243biological_processregulation of transcription elongation by RNA polymerase II
O0043231cellular_componentintracellular membrane-bounded organelle
O0045171cellular_componentintercellular bridge
Z0000122biological_processnegative regulation of transcription by RNA polymerase II
Z0003682molecular_functionchromatin binding
Z0003723molecular_functionRNA binding
Z0003729molecular_functionmRNA binding
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0006354biological_processDNA-templated transcription elongation
Z0006357biological_processregulation of transcription by RNA polymerase II
Z0006368biological_processtranscription elongation by RNA polymerase II
Z0016239biological_processpositive regulation of macroautophagy
Z0019899molecular_functionenzyme binding
Z0032044cellular_componentDSIF complex
Z0032784biological_processregulation of DNA-templated transcription elongation
Z0032785biological_processnegative regulation of DNA-templated transcription, elongation
Z0032786biological_processpositive regulation of DNA-templated transcription, elongation
Z0034243biological_processregulation of transcription elongation by RNA polymerase II
Z0045944biological_processpositive regulation of transcription by RNA polymerase II
Z0046982molecular_functionprotein heterodimerization activity
Z0140673biological_processtranscription elongation-coupled chromatin remodeling
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI
ChainResidueDetails
CASP136-ILE148

site_idPS00115
Number of Residues7
DetailsRNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA
ChainResidueDetails
ATYR1593-ALA1599
ATYR1671-SER1677
ATYR1678-SER1684
ATYR1685-SER1691
ATYR1692-SER1698
ATYR1699-SER1705
ATYR1706-SER1712
ATYR1713-SER1719
ATYR1720-SER1726
ATYR1727-SER1733
ATYR1734-SER1740
ATYR1615-SER1621
ATYR1741-ASN1747
ATYR1748-ASN1754
ATYR1755-SER1761
ATYR1762-SER1768
ATYR1769-ASN1775
ATYR1776-ASN1782
ATYR1783-SER1789
ATYR1790-SER1796
ATYR1797-SER1803
ATYR1818-SER1824
ATYR1622-SER1628
ATYR1825-SER1831
ATYR1832-LYS1838
ATYR1839-SER1845
ATYR1853-LYS1859
ATYR1860-LYS1866
ATYR1867-LYS1873
ATYR1874-THR1880
ATYR1888-THR1894
ATYR1902-LYS1908
ATYR1909-THR1915
ATYR1629-ASN1635
ATYR1916-LYS1922
ATYR1923-THR1929
ATYR1930-LYS1936
ATYR1947-THR1953
ATYR1636-SER1642
ATYR1643-SER1649
ATYR1650-SER1656
ATYR1657-SER1663
ATYR1664-SER1670

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH
ChainResidueDetails
ITYR112-HIS118

site_idPS00446
Number of Residues41
DetailsRNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP
ChainResidueDetails
CASN32-PRO72

site_idPS00466
Number of Residues38
DetailsZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW
ChainResidueDetails
ICYS86-TRP123

site_idPS01030
Number of Residues27
DetailsRNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC
ChainResidueDetails
IPHE16-CYS42

site_idPS01110
Number of Residues14
DetailsRNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE
ChainResidueDetails
EHIS142-GLU155

site_idPS01111
Number of Residues15
DetailsRNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ
ChainResidueDetails
FTHR58-GLN72

site_idPS01112
Number of Residues10
DetailsRNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG
ChainResidueDetails
JILE2-GLY11

site_idPS01154
Number of Residues32
DetailsRNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP
ChainResidueDetails
KILE35-PRO66

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
ChainResidueDetails
BGLY1009-THR1021

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:28892040, ECO:0007744|PDB:5OIK
ChainResidueDetails
ZLYS579
ZARG619
AARG358
AARG460
AASP499
AARG1416
AARG1421

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O55201
ChainResidueDetails
ZSER32
AASP495
ZSER36
ACYS81
AHIS84
ACYS111
ACYS114
ACYS154
ACYS184
AASN493

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ZSER666
ICYS20
ICYS39
ICYS42

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine; by PRMT1; alternate => ECO:0000269|PubMed:12718890
ChainResidueDetails
ZARG681
ZARG696
ICYS114
ICYS119

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ZSER686
ASER1868
ASER1875
ASER1878
ASER1882
ASER1896
ASER1899
ASER1906
ASER1913
ASER1917
ASER1920
ZSER789
ASER1927
ASER1931
ASER1934
ZSER804
ASER1845
ASER1849
ASER1850
ASER1857
ASER1861
ASER1864

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:12718890
ChainResidueDetails
ZARG698

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O55201
ChainResidueDetails
ZLYS718

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CDK9 => ECO:0000269|PubMed:10757782
ChainResidueDetails
ZTHR775
ZTHR784

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ZTHR791
ATHR1926
ATHR1929
ATHR1933
ZTHR806
ATHR1863
ATHR1870
ATHR1877
ATHR1885
ATHR1912
ATHR1915
ATHR1919

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ZTHR1034

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ZLYS143
ALYS1866
ALYS1873
ALYS1887
ALYS1922
ALYS1936

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ATYR1860
ZLYS1037
ATYR1874
ATYR1881
ATYR1909
ATYR1916
ATYR1923
ATYR1930

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08775
ChainResidueDetails
ATHR1894

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: N6,N6-dimethyllysine => ECO:0000250|UniProtKB:P08775
ChainResidueDetails
ALYS1908

site_idSWS_FT_FI15
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000250|UniProtKB:P24928
ChainResidueDetails
ALYS1268

226707

PDB entries from 2024-10-30

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