7OB9

Cryo-EM structure of human RNA Polymerase I in elongation state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0000785	cellular_component	chromatin
A	0001650	cellular_component	fibrillar center
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005736	cellular_component	RNA polymerase I complex
A	0006351	biological_process	DNA-templated transcription
A	0006360	biological_process	transcription by RNA polymerase I
A	0006361	biological_process	transcription initiation at RNA polymerase I promoter
A	0006362	biological_process	transcription elongation by RNA polymerase I
A	0006363	biological_process	termination of RNA polymerase I transcription
A	0008270	molecular_function	zinc ion binding
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
A	0046872	molecular_function	metal ion binding
A	0071667	molecular_function	DNA/RNA hybrid binding
A	1904750	biological_process	negative regulation of protein localization to nucleolus
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001650	cellular_component	fibrillar center
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005736	cellular_component	RNA polymerase I complex
B	0006351	biological_process	DNA-templated transcription
B	0006361	biological_process	transcription initiation at RNA polymerase I promoter
B	0006362	biological_process	transcription elongation by RNA polymerase I
B	0006363	biological_process	termination of RNA polymerase I transcription
B	0008270	molecular_function	zinc ion binding
B	0014029	biological_process	neural crest formation
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
B	0046872	molecular_function	metal ion binding
B	0071667	molecular_function	DNA/RNA hybrid binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001650	cellular_component	fibrillar center
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005666	cellular_component	RNA polymerase III complex
C	0005730	cellular_component	nucleolus
C	0005736	cellular_component	RNA polymerase I complex
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006360	biological_process	transcription by RNA polymerase I
C	0006361	biological_process	transcription initiation at RNA polymerase I promoter
C	0006362	biological_process	transcription elongation by RNA polymerase I
C	0006363	biological_process	termination of RNA polymerase I transcription
C	0006383	biological_process	transcription by RNA polymerase III
C	0006384	biological_process	transcription initiation at RNA polymerase III promoter
C	0006386	biological_process	termination of RNA polymerase III transcription
C	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
C	0046983	molecular_function	protein dimerization activity
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005730	cellular_component	nucleolus
E	0005736	cellular_component	RNA polymerase I complex
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006361	biological_process	transcription initiation at RNA polymerase I promoter
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006363	biological_process	termination of RNA polymerase I transcription
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006368	biological_process	transcription elongation by RNA polymerase II
E	0006383	biological_process	transcription by RNA polymerase III
E	0006384	biological_process	transcription initiation at RNA polymerase III promoter
E	0006386	biological_process	termination of RNA polymerase III transcription
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0042797	biological_process	tRNA transcription by RNA polymerase III
E	0050821	biological_process	protein stabilization
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005730	cellular_component	nucleolus
F	0005736	cellular_component	RNA polymerase I complex
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006361	biological_process	transcription initiation at RNA polymerase I promoter
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006363	biological_process	termination of RNA polymerase I transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0001650	cellular_component	fibrillar center
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005736	cellular_component	RNA polymerase I complex
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006361	biological_process	transcription initiation at RNA polymerase I promoter
G	0006362	biological_process	transcription elongation by RNA polymerase I
G	0006363	biological_process	termination of RNA polymerase I transcription
G	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005730	cellular_component	nucleolus
H	0005736	cellular_component	RNA polymerase I complex
H	0005829	cellular_component	cytosol
H	0006351	biological_process	DNA-templated transcription
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0032993	cellular_component	protein-DNA complex
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001650	cellular_component	fibrillar center
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005736	cellular_component	RNA polymerase I complex
I	0006139	biological_process	nucleobase-containing compound metabolic process
I	0006351	biological_process	DNA-templated transcription
I	0006361	biological_process	transcription initiation at RNA polymerase I promoter
I	0006362	biological_process	transcription elongation by RNA polymerase I
I	0006363	biological_process	termination of RNA polymerase I transcription
I	0008270	molecular_function	zinc ion binding
I	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005730	cellular_component	nucleolus
J	0005736	cellular_component	RNA polymerase I complex
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006356	biological_process	regulation of transcription by RNA polymerase I
J	0006360	biological_process	transcription by RNA polymerase I
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0006362	biological_process	transcription elongation by RNA polymerase I
J	0006363	biological_process	termination of RNA polymerase I transcription
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0006383	biological_process	transcription by RNA polymerase III
J	0006384	biological_process	transcription initiation at RNA polymerase III promoter
J	0006386	biological_process	termination of RNA polymerase III transcription
J	0008270	molecular_function	zinc ion binding
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005666	cellular_component	RNA polymerase III complex
K	0005730	cellular_component	nucleolus
K	0005736	cellular_component	RNA polymerase I complex
K	0006351	biological_process	DNA-templated transcription
K	0006361	biological_process	transcription initiation at RNA polymerase I promoter
K	0006362	biological_process	transcription elongation by RNA polymerase I
K	0006363	biological_process	termination of RNA polymerase I transcription
K	0006383	biological_process	transcription by RNA polymerase III
K	0006384	biological_process	transcription initiation at RNA polymerase III promoter
K	0006386	biological_process	termination of RNA polymerase III transcription
K	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0001650	cellular_component	fibrillar center
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0005829	cellular_component	cytosol
L	0006351	biological_process	DNA-templated transcription
L	0006356	biological_process	regulation of transcription by RNA polymerase I
L	0006361	biological_process	transcription initiation at RNA polymerase I promoter
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006363	biological_process	termination of RNA polymerase I transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
L	0008270	molecular_function	zinc ion binding
L	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
L	0046872	molecular_function	metal ion binding
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0001179	molecular_function	RNA polymerase I general transcription initiation factor binding
M	0001188	biological_process	RNA polymerase I preinitiation complex assembly
M	0001650	cellular_component	fibrillar center
M	0003677	molecular_function	DNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0005736	cellular_component	RNA polymerase I complex
M	0006351	biological_process	DNA-templated transcription
M	0006361	biological_process	transcription initiation at RNA polymerase I promoter
M	0006362	biological_process	transcription elongation by RNA polymerase I
M	0006363	biological_process	termination of RNA polymerase I transcription
M	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
N	0000120	cellular_component	RNA polymerase I transcription regulator complex
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0001650	cellular_component	fibrillar center
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005730	cellular_component	nucleolus
N	0005736	cellular_component	RNA polymerase I complex
N	0006360	biological_process	transcription by RNA polymerase I
N	0006361	biological_process	transcription initiation at RNA polymerase I promoter
N	0006362	biological_process	transcription elongation by RNA polymerase I
N	0006363	biological_process	termination of RNA polymerase I transcription
N	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
N	0009303	biological_process	rRNA transcription
N	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I

Functional Information from PROSITE/UniProt

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRillaevptmAvekVlvynNtSivqDEiLAhRLGLIP

Chain	Residue	Details
C	ASN74-PRO114

---

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CprCghegmayhtRQMRSaDEGqtvfytCtn...CkfqE

Chain	Residue	Details
I	CYS87-GLU122

---

site_id	PS01030
Number of Residues	23
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCSDCGSVLplpgaqdtvt....CirC

Chain	Residue	Details
I	PHE19-CYS41

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. LheEdHTLgNsLrymImknpeVefcgYtttHP

Chain	Residue	Details
K	LEU44-PRO75

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGI

Chain	Residue	Details
B	GLY880-ILE892

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	91
Details	Region: {"description":"Clamp","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Region: {"description":"Rudder","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	74
Details	Region: {"description":"Involved in RRN3 binding to Pol I complex","evidences":[{"source":"PubMed","id":"34887565","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Region: {"description":"Funnel","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	41
Details	Region: {"description":"Bridging helix","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	95
Details	Region: {"description":"Mediates the interaction with TOP2A","evidences":[{"source":"PubMed","id":"36271492","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	41
Details	Region: {"description":"Trigger loop","evidences":[{"source":"UniProtKB","id":"G3MZY8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34887565","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34887565","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OB9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7VBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P24928","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Site: {"description":"NTP recognition and base pairing","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	46
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	14
Details	Region: {"description":"Loop B","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	11
Details	Region: {"description":"Loop A","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	14
Details	Region: {"description":"Fork loop 1","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	15
Details	Region: {"description":"Fork loop 2","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P08518","evidenceCode":"ECO:0000250"},{"source":"UniProtKB","id":"P30876","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Site: {"description":"Active site gating; blocks backward movement of nascent RNA","evidences":[{"source":"PubMed","id":"34671025","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	24
Details	Region: {"description":"Non-specific ssDNA binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	21
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"34887565","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OB9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34887565","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7OB9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	20
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AE1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33558766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33674783","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DN3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7D58","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	12
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"16809778","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24207024","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---