7N0A

Structure of Human Leukaemia Inhibitory Factor with Fab MSC1

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005102	molecular_function	signaling receptor binding
C	0005125	molecular_function	cytokine activity
C	0005146	molecular_function	leukemia inhibitory factor receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0006955	biological_process	immune response
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0010646	biological_process	regulation of cell communication
C	0023051	biological_process	regulation of signaling
C	0030154	biological_process	cell differentiation
C	0030225	biological_process	macrophage differentiation
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045595	biological_process	regulation of cell differentiation
C	0045651	biological_process	positive regulation of macrophage differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046888	biological_process	negative regulation of hormone secretion
C	0048861	biological_process	leukemia inhibitory factor signaling pathway
C	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
C	0051240	biological_process	positive regulation of multicellular organismal process
C	0072108	biological_process	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
C	0072307	biological_process	regulation of metanephric nephron tubule epithelial cell differentiation
C	0097696	biological_process	cell surface receptor signaling pathway via STAT
C	1904894	biological_process	positive regulation of receptor signaling pathway via STAT
C	2000026	biological_process	regulation of multicellular organismal development

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
A	TYR198-HIS204
B	TYR199-HIS205

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site_id	PS00590
Number of Residues	20
Details	LIF_OSM LIF / OSM family signature. SgkdvFQkKklgCqLLgkYK

Chain	Residue	Details
C	SER151-LYS170

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8489250","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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