7MTB

Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0000166	molecular_function	nucleotide binding
G	0001750	cellular_component	photoreceptor outer segment
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006468	biological_process	protein phosphorylation
G	0007601	biological_process	visual perception
G	0009966	biological_process	regulation of signal transduction
G	0016020	cellular_component	membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0022400	biological_process	regulation of opsin-mediated signaling pathway
G	0050254	molecular_function	rhodopsin kinase activity
G	0097381	cellular_component	photoreceptor disc membrane
R	0000139	cellular_component	Golgi membrane
R	0001750	cellular_component	photoreceptor outer segment
R	0001917	cellular_component	photoreceptor inner segment
R	0001965	molecular_function	G-protein alpha-subunit binding
R	0002046	molecular_function	opsin binding
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005085	molecular_function	guanyl-nucleotide exchange factor activity
R	0005502	molecular_function	11-cis retinal binding
R	0005515	molecular_function	protein binding
R	0005794	cellular_component	Golgi apparatus
R	0005886	cellular_component	plasma membrane
R	0005911	cellular_component	cell-cell junction
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007601	biological_process	visual perception
R	0007602	biological_process	phototransduction
R	0007603	biological_process	phototransduction, visible light
R	0008020	molecular_function	G protein-coupled photoreceptor activity
R	0008270	molecular_function	zinc ion binding
R	0009416	biological_process	response to light stimulus
R	0009881	molecular_function	photoreceptor activity
R	0016020	cellular_component	membrane
R	0016038	biological_process	absorption of visible light
R	0016056	biological_process	G protein-coupled opsin signaling pathway
R	0019867	cellular_component	outer membrane
R	0042622	cellular_component	photoreceptor outer segment membrane
R	0042802	molecular_function	identical protein binding
R	0046872	molecular_function	metal ion binding
R	0060342	cellular_component	photoreceptor inner segment membrane
R	0071482	biological_process	cellular response to light stimulus
R	0097225	cellular_component	sperm midpiece
R	0097381	cellular_component	photoreceptor disc membrane
R	0097648	cellular_component	G protein-coupled receptor complex
R	1990763	molecular_function	arrestin family protein binding
R	1990913	cellular_component	sperm head plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK

Chain	Residue	Details
G	LEU193-LYS216

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL

Chain	Residue	Details
G	ILE310-LEU322

---

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. IALwSLVVLAIERYVvV

Chain	Residue	Details
R	ILE123-VAL139

---

site_id	PS00238
Number of Residues	17
Details	OPSIN Visual pigments (opsins) retinal binding site. IPaFfAKTSAvyNPviY

Chain	Residue	Details
R	ILE290-TYR306

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR194-HIS200
H	TYR207-HIS213

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	265
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA and autocatalysis","evidences":[{"source":"PubMed","id":"1527025","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"1527025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"1527025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	87
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	56
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17060607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17825322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563085","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18645239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Motif: {"description":"'Ionic lock' involved in activated form stabilization","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Site: {"description":"Plays an important role in the conformation switch to the active conformation","evidences":[{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N6-(retinylidene)lysine","evidences":[{"source":"PubMed","id":"10926528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12044163","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16586416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17449675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23303210","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6870827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1512231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3350146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1512231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27458239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3350146","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11425302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11972040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15327956","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15491621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16908857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18818650","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21389983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22198838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23579341","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25205354","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26526852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"468821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6759163","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1L9H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HPY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CAP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TE3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---