7MRU

Crystal structure of S62A MIF2 mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004167	molecular_function	dopachrome isomerase activity
A	0005126	molecular_function	cytokine receptor binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0010760	biological_process	negative regulation of macrophage chemotaxis
A	0016829	molecular_function	lyase activity
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0033981	molecular_function	D-dopachrome decarboxylase activity
A	0042438	biological_process	melanin biosynthetic process
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050729	biological_process	positive regulation of inflammatory response
A	0070062	cellular_component	extracellular exosome
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0004167	molecular_function	dopachrome isomerase activity
B	0005126	molecular_function	cytokine receptor binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0010760	biological_process	negative regulation of macrophage chemotaxis
B	0016829	molecular_function	lyase activity
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0033981	molecular_function	D-dopachrome decarboxylase activity
B	0042438	biological_process	melanin biosynthetic process
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050729	biological_process	positive regulation of inflammatory response
B	0070062	cellular_component	extracellular exosome
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0004167	molecular_function	dopachrome isomerase activity
C	0005126	molecular_function	cytokine receptor binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0010760	biological_process	negative regulation of macrophage chemotaxis
C	0016829	molecular_function	lyase activity
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0033981	molecular_function	D-dopachrome decarboxylase activity
C	0042438	biological_process	melanin biosynthetic process
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050729	biological_process	positive regulation of inflammatory response
C	0070062	cellular_component	extracellular exosome
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue TRS B 201

Chain	Residue
A	PHE100
B	HOH359
B	HOH367
C	PHE100
B	PHE100
B	HOH301
B	HOH308
B	HOH321
B	HOH325
B	HOH329
B	HOH348
B	HOH358

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Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAqlsIaSIGvVG

Chain	Residue	Details
A	GLU54-GLY68

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N-acetylproline => ECO:0000250|UniProtKB:O35215

Chain	Residue	Details
A	PRO1
B	PRO1
C	PRO1

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site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O35215

Chain	Residue	Details
A	LYS32
B	LYS32
C	LYS32

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