7MHD
Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue ZEP A 601 |
| Chain | Residue |
| A | ILE250 |
| A | ALA367 |
| A | TYR424 |
| A | LEU427 |
| A | GLU431 |
| A | HIS481 |
| A | HOH720 |
| A | SER308 |
| A | TYR343 |
| A | VAL344 |
| A | TYR347 |
| A | TYR351 |
| A | ARG352 |
| A | ALA363 |
| A | GLU366 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022, ECO:0000269|PubMed:17618296 |
| Chain | Residue | Details |
| A | SER308 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022 |
| Chain | Residue | Details |
| A | HIS481 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR215 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER236 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19096 |
| Chain | Residue | Details |
| A | LYS391 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | LYS449 |
