7ME0
Cryo-EM structure of SARS-CoV-2 NSP15 NendoU at pH 6.0
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS234 | |
| B | HIS234 | |
| C | HIS234 | |
| D | HIS234 | |
| E | HIS234 | |
| F | HIS234 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS249 | |
| B | HIS249 | |
| C | HIS249 | |
| D | HIS249 | |
| E | HIS249 | |
| F | HIS249 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 | |
| C | LYS289 | |
| D | LYS289 | |
| E | LYS289 | |
| F | LYS289 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 | |
| C | LYS289 | |
| D | LYS289 | |
| E | LYS289 | |
| F | LYS289 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | THR340 | |
| B | THR340 | |
| C | THR340 | |
| D | THR340 | |
| E | THR340 | |
| F | THR340 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 | |
| C | LYS289 | |
| D | LYS289 | |
| E | LYS289 | |
| F | LYS289 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | SER293 | |
| B | SER293 | |
| C | SER293 | |
| D | SER293 | |
| E | SER293 | |
| F | SER293 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN346 | |
| B | GLN346 | |
| C | GLN346 | |
| D | GLN346 | |
| E | GLN346 | |
| F | GLN346 |
