7MBS

Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (open state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005227	molecular_function	calcium-activated cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005227	molecular_function	calcium-activated cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005227	molecular_function	calcium-activated cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005227	molecular_function	calcium-activated cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	160
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Motif: {"description":"Selectivity filter"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34168372","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JJH7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---