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7L7I

Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001934biological_processpositive regulation of protein phosphorylation
A0002134molecular_functionUTP binding
A0002135molecular_functionCTP binding
A0002218biological_processactivation of innate immune response
A0002230biological_processpositive regulation of defense response to virus by host
A0003009biological_processskeletal muscle contraction
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006457biological_processprotein folding
A0006839biological_processmitochondrial transport
A0006986biological_processresponse to unfolded protein
A0007004biological_processtelomere maintenance via telomerase
A0009408biological_processresponse to heat
A0009409biological_processresponse to cold
A0009410biological_processresponse to xenobiotic stimulus
A0009651biological_processresponse to salt stress
A0009986cellular_componentcell surface
A0010592biological_processpositive regulation of lamellipodium assembly
A0010659biological_processcardiac muscle cell apoptotic process
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017098molecular_functionsulfonylurea receptor binding
A0019903molecular_functionprotein phosphatase binding
A0023026molecular_functionMHC class II protein complex binding
A0030235molecular_functionnitric-oxide synthase regulator activity
A0030911molecular_functionTPR domain binding
A0031396biological_processregulation of protein ubiquitination
A0031526cellular_componentbrush border membrane
A0031625molecular_functionubiquitin protein ligase binding
A0032273biological_processpositive regulation of protein polymerization
A0032564molecular_functiondATP binding
A0032728biological_processpositive regulation of interferon-beta production
A0032880biological_processregulation of protein localization
A0032991cellular_componentprotein-containing complex
A0034605biological_processcellular response to heat
A0034774cellular_componentsecretory granule lumen
A0036126cellular_componentsperm flagellum
A0042026biological_processprotein refolding
A0042220biological_processresponse to cocaine
A0042307biological_processpositive regulation of protein import into nucleus
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042826molecular_functionhistone deacetylase binding
A0042981biological_processregulation of apoptotic process
A0043025cellular_componentneuronal cell body
A0043202cellular_componentlysosomal lumen
A0043209cellular_componentmyelin sheath
A0043254biological_processregulation of protein-containing complex assembly
A0043335biological_processprotein unfolding
A0043627biological_processresponse to estrogen
A0044183molecular_functionprotein folding chaperone
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0044325molecular_functiontransmembrane transporter binding
A0045040biological_processprotein insertion into mitochondrial outer membrane
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045732biological_processpositive regulation of protein catabolic process
A0045793biological_processpositive regulation of cell size
A0046677biological_processresponse to antibiotic
A0048156molecular_functiontau protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050821biological_processprotein stabilization
A0051020molecular_functionGTPase binding
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051082molecular_functionunfolded protein binding
A0051131biological_processchaperone-mediated protein complex assembly
A0060255biological_processregulation of macromolecule metabolic process
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061684biological_processchaperone-mediated autophagy
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070182molecular_functionDNA polymerase binding
A0071682cellular_componentendocytic vesicle lumen
A0097110molecular_functionscaffold protein binding
A0097226cellular_componentsperm mitochondrial sheath
A0097524cellular_componentsperm plasma membrane
A0097718molecular_functiondisordered domain specific binding
A0098586biological_processcellular response to virus
A0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
A0140662molecular_functionATP-dependent protein folding chaperone
A1902949biological_processpositive regulation of tau-protein kinase activity
A1904813cellular_componentficolin-1-rich granule lumen
A1905323biological_processtelomerase holoenzyme complex assembly
A1990782molecular_functionprotein tyrosine kinase binding
B0001764biological_processneuron migration
B0001934biological_processpositive regulation of protein phosphorylation
B0002134molecular_functionUTP binding
B0002135molecular_functionCTP binding
B0002218biological_processactivation of innate immune response
B0002230biological_processpositive regulation of defense response to virus by host
B0003009biological_processskeletal muscle contraction
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006457biological_processprotein folding
B0006839biological_processmitochondrial transport
B0006986biological_processresponse to unfolded protein
B0007004biological_processtelomere maintenance via telomerase
B0009408biological_processresponse to heat
B0009409biological_processresponse to cold
B0009410biological_processresponse to xenobiotic stimulus
B0009651biological_processresponse to salt stress
B0009986cellular_componentcell surface
B0010592biological_processpositive regulation of lamellipodium assembly
B0010659biological_processcardiac muscle cell apoptotic process
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017098molecular_functionsulfonylurea receptor binding
B0019903molecular_functionprotein phosphatase binding
B0023026molecular_functionMHC class II protein complex binding
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030911molecular_functionTPR domain binding
B0031396biological_processregulation of protein ubiquitination
B0031526cellular_componentbrush border membrane
B0031625molecular_functionubiquitin protein ligase binding
B0032273biological_processpositive regulation of protein polymerization
B0032564molecular_functiondATP binding
B0032728biological_processpositive regulation of interferon-beta production
B0032880biological_processregulation of protein localization
B0032991cellular_componentprotein-containing complex
B0034605biological_processcellular response to heat
B0034774cellular_componentsecretory granule lumen
B0036126cellular_componentsperm flagellum
B0042026biological_processprotein refolding
B0042220biological_processresponse to cocaine
B0042307biological_processpositive regulation of protein import into nucleus
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042826molecular_functionhistone deacetylase binding
B0042981biological_processregulation of apoptotic process
B0043025cellular_componentneuronal cell body
B0043202cellular_componentlysosomal lumen
B0043209cellular_componentmyelin sheath
B0043254biological_processregulation of protein-containing complex assembly
B0043335biological_processprotein unfolding
B0043627biological_processresponse to estrogen
B0044183molecular_functionprotein folding chaperone
B0044294cellular_componentdendritic growth cone
B0044295cellular_componentaxonal growth cone
B0044325molecular_functiontransmembrane transporter binding
B0045040biological_processprotein insertion into mitochondrial outer membrane
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045732biological_processpositive regulation of protein catabolic process
B0045793biological_processpositive regulation of cell size
B0046677biological_processresponse to antibiotic
B0048156molecular_functiontau protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050821biological_processprotein stabilization
B0051020molecular_functionGTPase binding
B0051022molecular_functionRho GDP-dissociation inhibitor binding
B0051082molecular_functionunfolded protein binding
B0051131biological_processchaperone-mediated protein complex assembly
B0060255biological_processregulation of macromolecule metabolic process
B0060452biological_processpositive regulation of cardiac muscle contraction
B0061684biological_processchaperone-mediated autophagy
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070182molecular_functionDNA polymerase binding
B0071682cellular_componentendocytic vesicle lumen
B0097110molecular_functionscaffold protein binding
B0097226cellular_componentsperm mitochondrial sheath
B0097524cellular_componentsperm plasma membrane
B0097718molecular_functiondisordered domain specific binding
B0098586biological_processcellular response to virus
B0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
B0140662molecular_functionATP-dependent protein folding chaperone
B1902949biological_processpositive regulation of tau-protein kinase activity
B1904813cellular_componentficolin-1-rich granule lumen
B1905323biological_processtelomerase holoenzyme complex assembly
B1990782molecular_functionprotein tyrosine kinase binding
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005515molecular_functionprotein binding
C0005528molecular_functionFK506 binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006457biological_processprotein folding
C0009617biological_processresponse to bacterium
C0016020cellular_componentmembrane
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031072molecular_functionheat shock protein binding
C0061077biological_processchaperone-mediated protein folding
C0070062cellular_componentextracellular exosome
E0000723biological_processtelomere maintenance
E0000781cellular_componentchromosome, telomeric region
E0001516biological_processprostaglandin biosynthetic process
E0003720molecular_functiontelomerase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005697cellular_componenttelomerase holoenzyme complex
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005978biological_processglycogen biosynthetic process
E0006457biological_processprotein folding
E0007004biological_processtelomere maintenance via telomerase
E0007165biological_processsignal transduction
E0016853molecular_functionisomerase activity
E0019371biological_processcyclooxygenase pathway
E0032991cellular_componentprotein-containing complex
E0042327biological_processpositive regulation of phosphorylation
E0042921biological_processintracellular glucocorticoid receptor signaling pathway
E0043588biological_processskin development
E0048144biological_processfibroblast proliferation
E0050220molecular_functionprostaglandin-E synthase activity
E0050821biological_processprotein stabilization
E0051082molecular_functionunfolded protein binding
E0051085biological_processchaperone cofactor-dependent protein refolding
E0051087molecular_functionprotein-folding chaperone binding
E0051131biological_processchaperone-mediated protein complex assembly
E0051879molecular_functionHsp90 protein binding
E0051973biological_processpositive regulation of telomerase activity
E0060430biological_processlung saccule development
E0070182molecular_functionDNA polymerase binding
E0101031cellular_componentprotein folding chaperone complex
E1905323biological_processtelomerase holoenzyme complex assembly
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue ANP A 801
ChainResidue
AGLU47
ATHR115
AGLY132
AGLN133
APHE134
AGLY135
AVAL136
AGLY137
APHE138
ATHR184
AARG400
AASN51
AALA55
ALYS58
AASP93
AMET98
AASN106
ASER113
AGLY114

site_idAC2
Number of Residues18
Detailsbinding site for residue ANP B 801
ChainResidue
BGLU47
BASN51
BALA55
BLYS58
BASP93
BASN106
BSER113
BGLY114
BTHR115
BGLY132
BGLN133
BPHE134
BGLY135
BVAL136
BGLY137
BPHE138
BTHR184
BARG400

Functional Information from PROSITE/UniProt
site_idPS00298
Number of Residues10
DetailsHSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE
ChainResidueDetails
ATYR38-GLU47

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-7 => ECO:0000269|PubMed:28863261
ChainResidueDetails
EASP142
AASP93
APHE138
BASN51
BASP93
BPHE138

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS33
AARG400
BLYS112
BARG400

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER44
ATHR7
BTHR5
BTHR7

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER85
ALYS84
BLYS58
BLYS84

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R0Q7
ChainResidueDetails
ESER100
BSER231

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|Ref.6, ECO:0007744|PubMed:16807684, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER113
BSER252

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231
ChainResidueDetails
ESER118
BSER263

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:24275569
ChainResidueDetails
ESER148
ESER151
BTYR313
BTYR492

site_idSWS_FT_FI9
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ELYS35
ALYS458
ELYS65
ALYS585
BLYS443
BLYS458
BLYS489
BLYS585

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P82995
ChainResidueDetails
ASER453
BSER453

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER476
ASER641
BSER476
BSER641

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:15937123
ChainResidueDetails
ACYS598
BCYS598

219140

PDB entries from 2024-05-01

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