7K17

Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0016301	molecular_function	kinase activity
B	0004677	molecular_function	DNA-dependent protein kinase activity
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0016301	molecular_function	kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKgg.EDLRQDqrveQ

Chain	Residue	Details
A	VAL3752-GLN3766

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site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ShAlicIshWILgIgDRHlnN

Chain	Residue	Details
A	SER3907-ASN3927

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:10026262, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER577
C	SER577

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000305|PubMed:10026262

Chain	Residue	Details
D	SER579
C	SER579

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:10026262

Chain	Residue	Details
D	SER580
C	SER580

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
D	LYS660
D	LYS665
C	LYS660
C	LYS665

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PRKDC => ECO:0000305|PubMed:10026262

Chain	Residue	Details
D	THR715
C	THR715

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site_id	SWS_FT_FI6
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS566
D	LYS669
D	LYS688
C	LYS566
C	LYS669
C	LYS688

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS568
C	LYS568

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