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7FDV

Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005543molecular_functionphospholipid binding
A0005739cellular_componentmitochondrion
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0008203biological_processcholesterol metabolic process
A0009897cellular_componentexternal side of plasma membrane
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010875biological_processpositive regulation of cholesterol efflux
A0010887biological_processnegative regulation of cholesterol storage
A0010888biological_processnegative regulation of lipid storage
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0019534molecular_functiontoxin transmembrane transporter activity
A0030301biological_processcholesterol transport
A0032367biological_processintracellular cholesterol transport
A0033344biological_processcholesterol efflux
A0033700biological_processphospholipid efflux
A0033993biological_processresponse to lipid
A0034041molecular_functionABC-type sterol transporter activity
A0034204biological_processlipid translocation
A0034374biological_processlow-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034436biological_processglycoprotein transport
A0042632biological_processcholesterol homeostasis
A0042803molecular_functionprotein homodimerization activity
A0042987biological_processamyloid precursor protein catabolic process
A0043531molecular_functionADP binding
A0043691biological_processreverse cholesterol transport
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046982molecular_functionprotein heterodimerization activity
A0046983molecular_functionprotein dimerization activity
A0050714biological_processpositive regulation of protein secretion
A0055037cellular_componentrecycling endosome
A0055085biological_processtransmembrane transport
A0055091biological_processphospholipid homeostasis
A0071403biological_processcellular response to high density lipoprotein particle stimulus
A0090181biological_processregulation of cholesterol metabolic process
A0090554molecular_functionphosphatidylcholine floppase activity
A0120020molecular_functioncholesterol transfer activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A1902004biological_processpositive regulation of amyloid-beta formation
D0000139cellular_componentGolgi membrane
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005543molecular_functionphospholipid binding
D0005739cellular_componentmitochondrion
D0005768cellular_componentendosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006869biological_processlipid transport
D0008203biological_processcholesterol metabolic process
D0009897cellular_componentexternal side of plasma membrane
D0010745biological_processnegative regulation of macrophage derived foam cell differentiation
D0010875biological_processpositive regulation of cholesterol efflux
D0010887biological_processnegative regulation of cholesterol storage
D0010888biological_processnegative regulation of lipid storage
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0019534molecular_functiontoxin transmembrane transporter activity
D0030301biological_processcholesterol transport
D0032367biological_processintracellular cholesterol transport
D0033344biological_processcholesterol efflux
D0033700biological_processphospholipid efflux
D0033993biological_processresponse to lipid
D0034041molecular_functionABC-type sterol transporter activity
D0034204biological_processlipid translocation
D0034374biological_processlow-density lipoprotein particle remodeling
D0034375biological_processhigh-density lipoprotein particle remodeling
D0034436biological_processglycoprotein transport
D0042632biological_processcholesterol homeostasis
D0042803molecular_functionprotein homodimerization activity
D0042987biological_processamyloid precursor protein catabolic process
D0043531molecular_functionADP binding
D0043691biological_processreverse cholesterol transport
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0046982molecular_functionprotein heterodimerization activity
D0046983molecular_functionprotein dimerization activity
D0050714biological_processpositive regulation of protein secretion
D0055037cellular_componentrecycling endosome
D0055085biological_processtransmembrane transport
D0055091biological_processphospholipid homeostasis
D0071403biological_processcellular response to high density lipoprotein particle stimulus
D0090181biological_processregulation of cholesterol metabolic process
D0090554molecular_functionphosphatidylcholine floppase activity
D0120020molecular_functioncholesterol transfer activity
D0140328molecular_functionfloppase activity
D0140359molecular_functionABC-type transporter activity
D1902004biological_processpositive regulation of amyloid-beta formation
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRKRLAIALEL
ChainResidueDetails
ALEU217-LEU231

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues944
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG426
APRO478-ASP506
AGLY556-PHE567
ALEU670-ARG678
DMET1-ARG426
DPRO478-ASP506
DGLY556-PHE567
DLEU670-ARG678

site_idSWS_FT_FI2
Number of Residues228
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AILE427-GLY445
DPHE534-ILE555
DVAL568-PHE586
DLEU650-VAL669
APHE457-PHE477
AVAL507-THR525
APHE534-ILE555
AVAL568-PHE586
ALEU650-VAL669
DILE427-GLY445
DPHE457-PHE477
DVAL507-THR525

site_idSWS_FT_FI3
Number of Residues158
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AASN446-GLY456
ASER526-ARG533
AASP587-TYR649
DASN446-GLY456
DSER526-ARG533
DASP587-TYR649

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY118
DGLY118

site_idSWS_FT_FI5
Number of Residues10
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:23388354
ChainResidueDetails
ACYS30
DCYS406
ACYS154
ACYS315
ACYS394
ACYS406
DCYS30
DCYS154
DCYS315
DCYS394

222036

PDB entries from 2024-07-03

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