Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7EZJ

Crystal structure of p73 DNA binding domain complex bound with 1 bp and 2 bp spacer DNA response elements.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000976	molecular_function	transcription cis-regulatory region binding
a	0003677	molecular_function	DNA binding
a	0003700	molecular_function	DNA-binding transcription factor activity
a	0005634	cellular_component	nucleus
a	0006355	biological_process	regulation of DNA-templated transcription
a	0006915	biological_process	apoptotic process
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
b	0000976	molecular_function	transcription cis-regulatory region binding
b	0003677	molecular_function	DNA binding
b	0003700	molecular_function	DNA-binding transcription factor activity
b	0005634	cellular_component	nucleus
b	0006355	biological_process	regulation of DNA-templated transcription
b	0006915	biological_process	apoptotic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006915	biological_process	apoptotic process
c	0000976	molecular_function	transcription cis-regulatory region binding
c	0003677	molecular_function	DNA binding
c	0003700	molecular_function	DNA-binding transcription factor activity
c	0005634	cellular_component	nucleus
c	0006355	biological_process	regulation of DNA-templated transcription
c	0006915	biological_process	apoptotic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
d	0000976	molecular_function	transcription cis-regulatory region binding
d	0003677	molecular_function	DNA binding
d	0003700	molecular_function	DNA-binding transcription factor activity
d	0005634	cellular_component	nucleus
d	0006355	biological_process	regulation of DNA-templated transcription
d	0006915	biological_process	apoptotic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006915	biological_process	apoptotic process
i	0000976	molecular_function	transcription cis-regulatory region binding
i	0003677	molecular_function	DNA binding
i	0003700	molecular_function	DNA-binding transcription factor activity
i	0005634	cellular_component	nucleus
i	0006355	biological_process	regulation of DNA-templated transcription
i	0006915	biological_process	apoptotic process
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005634	cellular_component	nucleus
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006915	biological_process	apoptotic process
j	0000976	molecular_function	transcription cis-regulatory region binding
j	0003677	molecular_function	DNA binding
j	0003700	molecular_function	DNA-binding transcription factor activity
j	0005634	cellular_component	nucleus
j	0006355	biological_process	regulation of DNA-templated transcription
j	0006915	biological_process	apoptotic process
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0003677	molecular_function	DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0005634	cellular_component	nucleus
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006915	biological_process	apoptotic process
k	0000976	molecular_function	transcription cis-regulatory region binding
k	0003677	molecular_function	DNA binding
k	0003700	molecular_function	DNA-binding transcription factor activity
k	0005634	cellular_component	nucleus
k	0006355	biological_process	regulation of DNA-templated transcription
k	0006915	biological_process	apoptotic process
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0003677	molecular_function	DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0005634	cellular_component	nucleus
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006915	biological_process	apoptotic process
l	0000976	molecular_function	transcription cis-regulatory region binding
l	0003677	molecular_function	DNA binding
l	0003700	molecular_function	DNA-binding transcription factor activity
l	0005634	cellular_component	nucleus
l	0006355	biological_process	regulation of DNA-templated transcription
l	0006915	biological_process	apoptotic process
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0003677	molecular_function	DNA binding
L	0003700	molecular_function	DNA-binding transcription factor activity
L	0005634	cellular_component	nucleus
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006915	biological_process	apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCVGGMNRR

Chain	Residue	Details
A	MET257-ARG269

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS194
C	HIS197
C	CYS258
C	CYS262
D	CYS194
D	HIS197
D	CYS258
D	CYS262
I	CYS194
I	HIS197
I	CYS258
A	HIS197
I	CYS262
J	CYS194
J	HIS197
J	CYS258
J	CYS262
K	CYS194
K	HIS197
K	CYS258
K	CYS262
L	CYS194
A	CYS258
L	HIS197
L	CYS258
L	CYS262
a	CYS194
a	HIS197
a	CYS258
a	CYS262
b	CYS194
b	HIS197
b	CYS258
A	CYS262
b	CYS262
c	CYS194
c	HIS197
c	CYS258
c	CYS262
d	CYS194
d	HIS197
d	CYS258
d	CYS262
i	CYS194
B	CYS194
i	HIS197
i	CYS258
i	CYS262
j	CYS194
j	HIS197
j	CYS258
j	CYS262
k	CYS194
k	HIS197
k	CYS258
B	HIS197
k	CYS262
l	CYS194
l	HIS197
l	CYS258
l	CYS262
B	CYS258
B	CYS262
C	CYS194

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)