7ET1
Cryo-EM structure of the gastric proton pump K791S/E820D/Y340N/E936V/Y799W mutant in K+-occluded (K+)E2-AlF state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0005215 | molecular_function | transporter activity |
A | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0005889 | cellular_component | potassium:proton exchanging ATPase complex |
A | 0006813 | biological_process | potassium ion transport |
A | 0006883 | biological_process | intracellular sodium ion homeostasis |
A | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
A | 0008900 | molecular_function | P-type potassium:proton transporter activity |
A | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
A | 0016020 | cellular_component | membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0016887 | molecular_function | ATP hydrolysis activity |
A | 0030007 | biological_process | intracellular potassium ion homeostasis |
A | 0030955 | molecular_function | potassium ion binding |
A | 0036376 | biological_process | sodium ion export across plasma membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0071805 | biological_process | potassium ion transmembrane transport |
A | 1902600 | biological_process | proton transmembrane transport |
A | 1990573 | biological_process | potassium ion import across plasma membrane |
B | 0001671 | molecular_function | ATPase activator activity |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0005889 | cellular_component | potassium:proton exchanging ATPase complex |
B | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
B | 0006813 | biological_process | potassium ion transport |
B | 0006814 | biological_process | sodium ion transport |
B | 0006883 | biological_process | intracellular sodium ion homeostasis |
B | 0007155 | biological_process | cell adhesion |
B | 0016324 | cellular_component | apical plasma membrane |
B | 0030007 | biological_process | intracellular potassium ion homeostasis |
B | 0036376 | biological_process | sodium ion export across plasma membrane |
B | 0071805 | biological_process | potassium ion transmembrane transport |
B | 1902600 | biological_process | proton transmembrane transport |
B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 194 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | GLU97-ALA117 | |
A | GLN996-LYS1016 | |
A | LEU141-PHE161 | |
A | GLU298-ILE317 | |
A | MET330-ALA347 | |
A | LYS782-ILE801 | |
A | GLY812-ALA832 | |
A | LEU853-PHE875 | |
A | TYR928-LYS947 | |
A | ARG962-TYR980 |
site_id | SWS_FT_FI2 |
Number of Residues | 107 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
A | ALA118-TYR140 | |
A | VAL318-ALA329 | |
A | TYR802-LEU811 | |
A | THR876-CYS927 | |
A | CYS981-PHE995 |
site_id | SWS_FT_FI3 |
Number of Residues | 616 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | LYS162-ILE297 | |
A | THR348-LEU781 | |
A | TYR833-ARG852 | |
A | THR948-ASN961 | |
A | LEU1017-TYR1033 | |
B | ASN221 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:1720615 |
Chain | Residue | Details |
A | ASP385 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH |
Chain | Residue | Details |
A | VAL338 | |
A | ALA339 | |
A | VAL341 | |
A | GLU343 | |
A | GLU795 | |
A | ASP820 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29618813, ECO:0000269|PubMed:31436534, ECO:0007744|PDB:5YLU, ECO:0007744|PDB:6JXH |
Chain | Residue | Details |
A | ASP385 | |
A | THR387 | |
A | ASP726 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP730 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PIE5 |
Chain | Residue | Details |
A | SER461 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P50993 |
Chain | Residue | Details |
A | SER599 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09626 |
Chain | Residue | Details |
A | SER838 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250 |
Chain | Residue | Details |
A | SER952 |