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7EKP

human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0034220biological_processmonoatomic ion transmembrane transport
A0045211cellular_componentpostsynaptic membrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0034220biological_processmonoatomic ion transmembrane transport
B0045211cellular_componentpostsynaptic membrane
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0034220biological_processmonoatomic ion transmembrane transport
C0045211cellular_componentpostsynaptic membrane
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0034220biological_processmonoatomic ion transmembrane transport
D0045211cellular_componentpostsynaptic membrane
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0016020cellular_componentmembrane
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0034220biological_processmonoatomic ion transmembrane transport
E0045211cellular_componentpostsynaptic membrane
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC
ChainResidueDetails
ACYS150-CYS164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1035
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLY23-THR230
BGLY23-THR230
CGLY23-THR230
DGLY23-THR230
EGLY23-THR230

site_idSWS_FT_FI2
Number of Residues415
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU231-PRO255
CILE262-ALA280
CTYR296-TYR317
CLEU470-ALA490
DLEU231-PRO255
DILE262-ALA280
DTYR296-TYR317
DLEU470-ALA490
ELEU231-PRO255
EILE262-ALA280
ETYR296-TYR317
AILE262-ALA280
ELEU470-ALA490
ATYR296-TYR317
ALEU470-ALA490
BLEU231-PRO255
BILE262-ALA280
BTYR296-TYR317
BLEU470-ALA490
CLEU231-PRO255

site_idSWS_FT_FI3
Number of Residues755
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AHIS318-ARG469
BHIS318-ARG469
CHIS318-ARG469
DHIS318-ARG469
EHIS318-ARG469

site_idSWS_FT_FI4
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN46
DASN46
DASN90
DASN133
EASN46
EASN90
EASN133
AASN90
AASN133
BASN46
BASN90
BASN133
CASN46
CASN90
CASN133

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PDB entries from 2024-11-13

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