7EKP
human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045211 | cellular_component | postsynaptic membrane |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045211 | cellular_component | postsynaptic membrane |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0045211 | cellular_component | postsynaptic membrane |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0045211 | cellular_component | postsynaptic membrane |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC |
| Chain | Residue | Details |
| A | CYS150-CYS164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1050 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:33735609, ECO:0007744|PDB:7KOO |
| Chain | Residue | Details |
| A | GLY23-TYR233 | |
| B | GLY23-TYR233 | |
| C | GLY23-TYR233 | |
| D | GLY23-TYR233 | |
| E | GLY23-TYR233 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 425 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:33735609, ECO:0007744|PDB:7KOO |
| Chain | Residue | Details |
| A | GLY234-LEU254 | |
| C | GLY259-VAL279 | |
| C | LEU292-LEU315 | |
| C | VAL467-SER489 | |
| D | GLY234-LEU254 | |
| D | GLY259-VAL279 | |
| D | LEU292-LEU315 | |
| D | VAL467-SER489 | |
| E | GLY234-LEU254 | |
| E | GLY259-VAL279 | |
| E | LEU292-LEU315 | |
| A | GLY259-VAL279 | |
| E | VAL467-SER489 | |
| A | LEU292-LEU315 | |
| A | VAL467-SER489 | |
| B | GLY234-LEU254 | |
| B | GLY259-VAL279 | |
| B | LEU292-LEU315 | |
| B | VAL467-SER489 | |
| C | GLY234-LEU254 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 750 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN316-VAL466 | |
| B | GLN316-VAL466 | |
| C | GLN316-VAL466 | |
| D | GLN316-VAL466 | |
| E | GLN316-VAL466 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D |
| Chain | Residue | Details |
| A | ARG42 | |
| B | ARG42 | |
| C | ARG42 | |
| D | ARG42 | |
| E | ARG42 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33735609, ECO:0000269|PubMed:38382524, ECO:0007744|PDB:7KOX, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V8A, ECO:0007744|PDB:8V8D |
| Chain | Residue | Details |
| A | VAL44 | |
| B | VAL44 | |
| C | VAL44 | |
| D | VAL44 | |
| E | VAL44 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8UT1, ECO:0007744|PDB:8UZJ, ECO:0007744|PDB:8V80, ECO:0007744|PDB:8V82, ECO:0007744|PDB:8V88, ECO:0007744|PDB:8V8C, ECO:0007744|PDB:8V8D |
| Chain | Residue | Details |
| A | SER172 | |
| B | SER172 | |
| C | SER172 | |
| D | SER172 | |
| E | SER172 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38382524, ECO:0007744|PDB:8V8D |
| Chain | Residue | Details |
| A | TYR210 | |
| B | TYR210 | |
| C | TYR210 | |
| D | TYR210 | |
| E | TYR210 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN46 | |
| D | ASN46 | |
| D | ASN90 | |
| D | ASN133 | |
| E | ASN46 | |
| E | ASN90 | |
| E | ASN133 | |
| A | ASN90 | |
| A | ASN133 | |
| B | ASN46 | |
| B | ASN90 | |
| B | ASN133 | |
| C | ASN46 | |
| C | ASN90 | |
| C | ASN133 |
