7EKP
human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045211 | cellular_component | postsynaptic membrane |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045211 | cellular_component | postsynaptic membrane |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0045211 | cellular_component | postsynaptic membrane |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0045211 | cellular_component | postsynaptic membrane |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0022848 | molecular_function | acetylcholine-gated monoatomic cation-selective channel activity |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0045211 | cellular_component | postsynaptic membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CyIdVrwFPfDvqhC |
| Chain | Residue | Details |
| A | CYS150-CYS164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1050 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 425 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Region: {"description":"Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane","evidences":[{"source":"UniProtKB","id":"P49582","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33735609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7KOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UT1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UZJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38382524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 15 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
