7EHL
Cryo-EM structure of human ABCB8 transporter in nucleotide binding state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0062157 | cellular_component | mitochondrial ATP-gated potassium channel complex |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0140141 | biological_process | mitochondrial potassium ion transmembrane transport |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0016020 | cellular_component | membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0062157 | cellular_component | mitochondrial ATP-gated potassium channel complex |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0140141 | biological_process | mitochondrial potassium ion transmembrane transport |
| B | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRLAIARAL |
| Chain | Residue | Details |
| A | LEU612-LEU626 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2017","submissionDatabase":"PDB data bank","title":"The crystal structure of human ABCB8 in an outward-facing state.","authors":["Faust B.","Pike A.C.W.","Shintre C.A.","Quiqley A.M.","Chu A.","Barr A.","Shrestha L.","Mukhopadhyay S.","Borkowska O.","Chalk R.","Burgess-Brown N.A.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Carpenter E.P."]}},{"source":"PDB","id":"5OCH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
