7EHL

Cryo-EM structure of human ABCB8 transporter in nucleotide binding state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006813	biological_process	potassium ion transport
A	0006884	biological_process	cell volume homeostasis
A	0015440	molecular_function	ABC-type peptide transporter activity
A	0015833	biological_process	peptide transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0031966	cellular_component	mitochondrial membrane
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
A	0062157	cellular_component	mitochondrial ATP-gated potassium channel complex
A	0071805	biological_process	potassium ion transmembrane transport
A	0140141	biological_process	mitochondrial potassium ion transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006813	biological_process	potassium ion transport
B	0006884	biological_process	cell volume homeostasis
B	0015440	molecular_function	ABC-type peptide transporter activity
B	0015833	biological_process	peptide transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0031966	cellular_component	mitochondrial membrane
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
B	0062157	cellular_component	mitochondrial ATP-gated potassium channel complex
B	0071805	biological_process	potassium ion transmembrane transport
B	0140141	biological_process	mitochondrial potassium ion transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRLAIARAL

Chain	Residue	Details
A	LEU612-LEU626

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	TRANSMEM: Helical => ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	LEU145-ILE165
A	THR196-LEU216
A	LEU296-LEU316
B	LEU145-ILE165
B	THR196-LEU216
B	LEU296-LEU316

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site_id	SWS_FT_FI2
Number of Residues	894
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:31435016

Chain	Residue	Details
A	PRO166-SER195
A	ARG317-SER735
B	PRO166-SER195
B	ARG317-SER735

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site_id	SWS_FT_FI3
Number of Residues	156
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000305|PubMed:31435016

Chain	Residue	Details
A	SER217-THR295
B	SER217-THR295

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434, ECO:0000269|Ref.15, ECO:0007744|PDB:5OCH

Chain	Residue	Details
A	GLY507
B	GLY507

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