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7E9G

Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0010854molecular_functionadenylate cyclase regulator activity
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0034695biological_processresponse to prostaglandin E
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0001641molecular_functiongroup II metabotropic glutamate receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0005246molecular_functioncalcium channel regulator activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007194biological_processnegative regulation of adenylate cyclase activity
R0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
R0007215biological_processglutamate receptor signaling pathway
R0007216biological_processG protein-coupled glutamate receptor signaling pathway
R0007268biological_processchemical synaptic transmission
R0008066molecular_functionglutamate receptor activity
R0010467biological_processgene expression
R0014047biological_processglutamate secretion
R0014048biological_processregulation of glutamate secretion
R0014059biological_processregulation of dopamine secretion
R0016020cellular_componentmembrane
R0030424cellular_componentaxon
R0030425cellular_componentdendrite
R0033554biological_processcellular response to stress
R0035095biological_processbehavioral response to nicotine
R0042220biological_processresponse to cocaine
R0042734cellular_componentpresynaptic membrane
R0042995cellular_componentcell projection
R0043005cellular_componentneuron projection
R0045202cellular_componentsynapse
R0045211cellular_componentpostsynaptic membrane
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0051966biological_processregulation of synaptic transmission, glutamatergic
R0060292biological_processlong-term synaptic depression
R0090461biological_processintracellular glutamate homeostasis
R0097110molecular_functionscaffold protein binding
R0097449cellular_componentastrocyte projection
R0098978cellular_componentglutamatergic synapse
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R2001023biological_processregulation of response to drug
S0001641molecular_functiongroup II metabotropic glutamate receptor activity
S0004930molecular_functionG protein-coupled receptor activity
S0005246molecular_functioncalcium channel regulator activity
S0005515molecular_functionprotein binding
S0005886cellular_componentplasma membrane
S0007186biological_processG protein-coupled receptor signaling pathway
S0007194biological_processnegative regulation of adenylate cyclase activity
S0007196biological_processadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
S0007215biological_processglutamate receptor signaling pathway
S0007216biological_processG protein-coupled glutamate receptor signaling pathway
S0007268biological_processchemical synaptic transmission
S0008066molecular_functionglutamate receptor activity
S0010467biological_processgene expression
S0014047biological_processglutamate secretion
S0014048biological_processregulation of glutamate secretion
S0014059biological_processregulation of dopamine secretion
S0016020cellular_componentmembrane
S0030424cellular_componentaxon
S0030425cellular_componentdendrite
S0033554biological_processcellular response to stress
S0035095biological_processbehavioral response to nicotine
S0042220biological_processresponse to cocaine
S0042734cellular_componentpresynaptic membrane
S0042995cellular_componentcell projection
S0043005cellular_componentneuron projection
S0045202cellular_componentsynapse
S0045211cellular_componentpostsynaptic membrane
S0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
S0051966biological_processregulation of synaptic transmission, glutamatergic
S0060292biological_processlong-term synaptic depression
S0090461biological_processintracellular glutamate homeostasis
S0097110molecular_functionscaffold protein binding
S0097449cellular_componentastrocyte projection
S0098978cellular_componentglutamatergic synapse
S0099171biological_processpresynaptic modulation of chemical synaptic transmission
S2001023biological_processregulation of response to drug
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS
ChainResidueDetails
RVAL151-SER169

site_idPS00980
Number of Residues23
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWlCipCqpyeYrl...DefTCadC
ChainResidueDetails
RCYS518-CYS540

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM
ChainResidueDetails
RPHE756-MET766

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
AASN269
RGLU701-ASP725
RSER784-THR793
SGLU19-TRP567
SLYS626-ARG636
SGLU701-ASP725
SSER784-THR793

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
ATHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
RARG656-GLN679
RLYS748-LYS760
SARG591-GLU604
SARG656-GLN679
SLYS748-LYS760

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ALEU175
SLEU605-ALA625

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
AASP200
SLEU637-ASN655

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ASER326
SVAL680-VAL700

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178
SALA726-PHE747

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN204
SPHE761-THR783

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS351
SMET794-PHE819

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2
SLYS377
RALA166
RTYR216
RASP295
RLYS377
SSER145
SALA166
STYR216
SASP295

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
ACYS3
SASN547
RASN286
RASN338
RASN402
RASN547
SASN203
SASN286
SASN338
SASN402

226707

PDB entries from 2024-10-30

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