7DV4

Crystal structure of anti-CTLA-4 VH domain in complex with human CTLA-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
A	0042129	biological_process	regulation of T cell proliferation
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
C	0042129	biological_process	regulation of T cell proliferation
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
E	0042129	biological_process	regulation of T cell proliferation
G	0006955	biological_process	immune response
G	0016020	cellular_component	membrane
G	0042129	biological_process	regulation of T cell proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Homodimerization","evidences":[{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	20
Details	Region: {"description":"Important for interaction with CD80 and CD86","evidences":[{"source":"PubMed","id":"28484017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	101
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

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