7DR4

Complex of anti-human IL-2 antibody and human IL-2

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0002250	biological_process	adaptive immune response
G	0002366	biological_process	leukocyte activation involved in immune response
G	0002639	biological_process	positive regulation of immunoglobulin production
G	0002903	biological_process	negative regulation of B cell apoptotic process
G	0005125	molecular_function	cytokine activity
G	0005134	molecular_function	interleukin-2 receptor binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0006366	biological_process	transcription by RNA polymerase II
G	0006955	biological_process	immune response
G	0007155	biological_process	cell adhesion
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
G	0007267	biological_process	cell-cell signaling
G	0008083	molecular_function	growth factor activity
G	0008284	biological_process	positive regulation of cell population proliferation
G	0010467	biological_process	gene expression
G	0019209	molecular_function	kinase activator activity
G	0030101	biological_process	natural killer cell activation
G	0030217	biological_process	T cell differentiation
G	0030246	molecular_function	carbohydrate binding
G	0030307	biological_process	positive regulation of cell growth
G	0030890	biological_process	positive regulation of B cell proliferation
G	0031851	molecular_function	kappa-type opioid receptor binding
G	0032729	biological_process	positive regulation of type II interferon production
G	0032740	biological_process	positive regulation of interleukin-17 production
G	0034105	biological_process	positive regulation of tissue remodeling
G	0038110	biological_process	interleukin-2-mediated signaling pathway
G	0042098	biological_process	T cell proliferation
G	0042102	biological_process	positive regulation of T cell proliferation
G	0042104	biological_process	positive regulation of activated T cell proliferation
G	0043066	biological_process	negative regulation of apoptotic process
G	0043208	molecular_function	glycosphingolipid binding
G	0045471	biological_process	response to ethanol
G	0045582	biological_process	positive regulation of T cell differentiation
G	0045591	biological_process	positive regulation of regulatory T cell differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046013	biological_process	regulation of T cell homeostatic proliferation
G	0046651	biological_process	lymphocyte proliferation
G	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
G	0050672	biological_process	negative regulation of lymphocyte proliferation
G	0050728	biological_process	negative regulation of inflammatory response
G	0050729	biological_process	positive regulation of inflammatory response
G	0050798	biological_process	activated T cell proliferation
G	0060999	biological_process	positive regulation of dendritic spine development
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	0097696	biological_process	cell surface receptor signaling pathway via STAT
G	1900100	biological_process	positive regulation of plasma cell differentiation
G	1901327	biological_process	response to tacrolimus
G	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
G	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
I	0002250	biological_process	adaptive immune response
I	0002366	biological_process	leukocyte activation involved in immune response
I	0002639	biological_process	positive regulation of immunoglobulin production
I	0002903	biological_process	negative regulation of B cell apoptotic process
I	0005125	molecular_function	cytokine activity
I	0005134	molecular_function	interleukin-2 receptor binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0006366	biological_process	transcription by RNA polymerase II
I	0006955	biological_process	immune response
I	0007155	biological_process	cell adhesion
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
I	0007267	biological_process	cell-cell signaling
I	0008083	molecular_function	growth factor activity
I	0008284	biological_process	positive regulation of cell population proliferation
I	0010467	biological_process	gene expression
I	0019209	molecular_function	kinase activator activity
I	0030101	biological_process	natural killer cell activation
I	0030217	biological_process	T cell differentiation
I	0030246	molecular_function	carbohydrate binding
I	0030307	biological_process	positive regulation of cell growth
I	0030890	biological_process	positive regulation of B cell proliferation
I	0031851	molecular_function	kappa-type opioid receptor binding
I	0032729	biological_process	positive regulation of type II interferon production
I	0032740	biological_process	positive regulation of interleukin-17 production
I	0034105	biological_process	positive regulation of tissue remodeling
I	0038110	biological_process	interleukin-2-mediated signaling pathway
I	0042098	biological_process	T cell proliferation
I	0042102	biological_process	positive regulation of T cell proliferation
I	0042104	biological_process	positive regulation of activated T cell proliferation
I	0043066	biological_process	negative regulation of apoptotic process
I	0043208	molecular_function	glycosphingolipid binding
I	0045471	biological_process	response to ethanol
I	0045582	biological_process	positive regulation of T cell differentiation
I	0045591	biological_process	positive regulation of regulatory T cell differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0046013	biological_process	regulation of T cell homeostatic proliferation
I	0046651	biological_process	lymphocyte proliferation
I	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
I	0050672	biological_process	negative regulation of lymphocyte proliferation
I	0050728	biological_process	negative regulation of inflammatory response
I	0050729	biological_process	positive regulation of inflammatory response
I	0050798	biological_process	activated T cell proliferation
I	0060999	biological_process	positive regulation of dendritic spine development
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	0097696	biological_process	cell surface receptor signaling pathway via STAT
I	1900100	biological_process	positive regulation of plasma cell differentiation
I	1901327	biological_process	response to tacrolimus
I	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
I	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
J	0002250	biological_process	adaptive immune response
J	0002366	biological_process	leukocyte activation involved in immune response
J	0002639	biological_process	positive regulation of immunoglobulin production
J	0002903	biological_process	negative regulation of B cell apoptotic process
J	0005125	molecular_function	cytokine activity
J	0005134	molecular_function	interleukin-2 receptor binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006366	biological_process	transcription by RNA polymerase II
J	0006955	biological_process	immune response
J	0007155	biological_process	cell adhesion
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
J	0007267	biological_process	cell-cell signaling
J	0008083	molecular_function	growth factor activity
J	0008284	biological_process	positive regulation of cell population proliferation
J	0010467	biological_process	gene expression
J	0019209	molecular_function	kinase activator activity
J	0030101	biological_process	natural killer cell activation
J	0030217	biological_process	T cell differentiation
J	0030246	molecular_function	carbohydrate binding
J	0030307	biological_process	positive regulation of cell growth
J	0030890	biological_process	positive regulation of B cell proliferation
J	0031851	molecular_function	kappa-type opioid receptor binding
J	0032729	biological_process	positive regulation of type II interferon production
J	0032740	biological_process	positive regulation of interleukin-17 production
J	0034105	biological_process	positive regulation of tissue remodeling
J	0038110	biological_process	interleukin-2-mediated signaling pathway
J	0042098	biological_process	T cell proliferation
J	0042102	biological_process	positive regulation of T cell proliferation
J	0042104	biological_process	positive regulation of activated T cell proliferation
J	0043066	biological_process	negative regulation of apoptotic process
J	0043208	molecular_function	glycosphingolipid binding
J	0045471	biological_process	response to ethanol
J	0045582	biological_process	positive regulation of T cell differentiation
J	0045591	biological_process	positive regulation of regulatory T cell differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0046013	biological_process	regulation of T cell homeostatic proliferation
J	0046651	biological_process	lymphocyte proliferation
J	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
J	0050672	biological_process	negative regulation of lymphocyte proliferation
J	0050728	biological_process	negative regulation of inflammatory response
J	0050729	biological_process	positive regulation of inflammatory response
J	0050798	biological_process	activated T cell proliferation
J	0060999	biological_process	positive regulation of dendritic spine development
J	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
J	0097696	biological_process	cell surface receptor signaling pathway via STAT
J	1900100	biological_process	positive regulation of plasma cell differentiation
J	1901327	biological_process	response to tacrolimus
J	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
J	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation
K	0002250	biological_process	adaptive immune response
K	0002366	biological_process	leukocyte activation involved in immune response
K	0002639	biological_process	positive regulation of immunoglobulin production
K	0002903	biological_process	negative regulation of B cell apoptotic process
K	0005125	molecular_function	cytokine activity
K	0005134	molecular_function	interleukin-2 receptor binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0006366	biological_process	transcription by RNA polymerase II
K	0006955	biological_process	immune response
K	0007155	biological_process	cell adhesion
K	0007186	biological_process	G protein-coupled receptor signaling pathway
K	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
K	0007267	biological_process	cell-cell signaling
K	0008083	molecular_function	growth factor activity
K	0008284	biological_process	positive regulation of cell population proliferation
K	0010467	biological_process	gene expression
K	0019209	molecular_function	kinase activator activity
K	0030101	biological_process	natural killer cell activation
K	0030217	biological_process	T cell differentiation
K	0030246	molecular_function	carbohydrate binding
K	0030307	biological_process	positive regulation of cell growth
K	0030890	biological_process	positive regulation of B cell proliferation
K	0031851	molecular_function	kappa-type opioid receptor binding
K	0032729	biological_process	positive regulation of type II interferon production
K	0032740	biological_process	positive regulation of interleukin-17 production
K	0034105	biological_process	positive regulation of tissue remodeling
K	0038110	biological_process	interleukin-2-mediated signaling pathway
K	0042098	biological_process	T cell proliferation
K	0042102	biological_process	positive regulation of T cell proliferation
K	0042104	biological_process	positive regulation of activated T cell proliferation
K	0043066	biological_process	negative regulation of apoptotic process
K	0043208	molecular_function	glycosphingolipid binding
K	0045471	biological_process	response to ethanol
K	0045582	biological_process	positive regulation of T cell differentiation
K	0045591	biological_process	positive regulation of regulatory T cell differentiation
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046013	biological_process	regulation of T cell homeostatic proliferation
K	0046651	biological_process	lymphocyte proliferation
K	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
K	0050672	biological_process	negative regulation of lymphocyte proliferation
K	0050728	biological_process	negative regulation of inflammatory response
K	0050729	biological_process	positive regulation of inflammatory response
K	0050798	biological_process	activated T cell proliferation
K	0060999	biological_process	positive regulation of dendritic spine development
K	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
K	0097696	biological_process	cell surface receptor signaling pathway via STAT
K	1900100	biological_process	positive regulation of plasma cell differentiation
K	1901327	biological_process	response to tacrolimus
K	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
K	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
G	THR51-LEU63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684

Chain	Residue	Details
G	THR3
I	THR3
J	THR3
K	THR3

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