Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7DDE

Cryo-EM structure of the Ape4 and Nbr1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000324	cellular_component	fungal-type vacuole
A	0000328	cellular_component	fungal-type vacuole lumen
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0006508	biological_process	proteolysis
A	0006974	biological_process	DNA damage response
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008643	biological_process	carbohydrate transport
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0046872	molecular_function	metal ion binding
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0070006	molecular_function	metalloaminopeptidase activity
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
C	0000324	cellular_component	fungal-type vacuole
C	0000328	cellular_component	fungal-type vacuole lumen
C	0004177	molecular_function	aminopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006508	biological_process	proteolysis
C	0006974	biological_process	DNA damage response
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0008643	biological_process	carbohydrate transport
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0046872	molecular_function	metal ion binding
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0070006	molecular_function	metalloaminopeptidase activity
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
E	0000324	cellular_component	fungal-type vacuole
E	0000328	cellular_component	fungal-type vacuole lumen
E	0004177	molecular_function	aminopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0006508	biological_process	proteolysis
E	0006974	biological_process	DNA damage response
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0008643	biological_process	carbohydrate transport
E	0015768	biological_process	maltose transport
E	0016020	cellular_component	membrane
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0034219	biological_process	carbohydrate transmembrane transport
E	0034289	biological_process	detection of maltose stimulus
E	0042597	cellular_component	periplasmic space
E	0042956	biological_process	maltodextrin transmembrane transport
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0046872	molecular_function	metal ion binding
E	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
E	0055085	biological_process	transmembrane transport
E	0060326	biological_process	cell chemotaxis
E	0070006	molecular_function	metalloaminopeptidase activity
E	1901982	molecular_function	maltose binding
E	1990060	cellular_component	maltose transport complex
G	0000324	cellular_component	fungal-type vacuole
G	0000328	cellular_component	fungal-type vacuole lumen
G	0004177	molecular_function	aminopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0006508	biological_process	proteolysis
G	0006974	biological_process	DNA damage response
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0008643	biological_process	carbohydrate transport
G	0015768	biological_process	maltose transport
G	0016020	cellular_component	membrane
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0034219	biological_process	carbohydrate transmembrane transport
G	0034289	biological_process	detection of maltose stimulus
G	0042597	cellular_component	periplasmic space
G	0042956	biological_process	maltodextrin transmembrane transport
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0046872	molecular_function	metal ion binding
G	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
G	0055085	biological_process	transmembrane transport
G	0060326	biological_process	cell chemotaxis
G	0070006	molecular_function	metalloaminopeptidase activity
G	1901982	molecular_function	maltose binding
G	1990060	cellular_component	maltose transport complex
I	0000324	cellular_component	fungal-type vacuole
I	0000328	cellular_component	fungal-type vacuole lumen
I	0004177	molecular_function	aminopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0006508	biological_process	proteolysis
I	0006974	biological_process	DNA damage response
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0008643	biological_process	carbohydrate transport
I	0015768	biological_process	maltose transport
I	0016020	cellular_component	membrane
I	0030288	cellular_component	outer membrane-bounded periplasmic space
I	0034219	biological_process	carbohydrate transmembrane transport
I	0034289	biological_process	detection of maltose stimulus
I	0042597	cellular_component	periplasmic space
I	0042956	biological_process	maltodextrin transmembrane transport
I	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
I	0046872	molecular_function	metal ion binding
I	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
I	0055085	biological_process	transmembrane transport
I	0060326	biological_process	cell chemotaxis
I	0070006	molecular_function	metalloaminopeptidase activity
I	1901982	molecular_function	maltose binding
I	1990060	cellular_component	maltose transport complex
K	0000324	cellular_component	fungal-type vacuole
K	0000328	cellular_component	fungal-type vacuole lumen
K	0004177	molecular_function	aminopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0006508	biological_process	proteolysis
K	0006974	biological_process	DNA damage response
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0008643	biological_process	carbohydrate transport
K	0015768	biological_process	maltose transport
K	0016020	cellular_component	membrane
K	0030288	cellular_component	outer membrane-bounded periplasmic space
K	0034219	biological_process	carbohydrate transmembrane transport
K	0034289	biological_process	detection of maltose stimulus
K	0042597	cellular_component	periplasmic space
K	0042956	biological_process	maltodextrin transmembrane transport
K	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
K	0046872	molecular_function	metal ion binding
K	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
K	0055085	biological_process	transmembrane transport
K	0060326	biological_process	cell chemotaxis
K	0070006	molecular_function	metalloaminopeptidase activity
K	1901982	molecular_function	maltose binding
K	1990060	cellular_component	maltose transport complex
M	0000324	cellular_component	fungal-type vacuole
M	0000328	cellular_component	fungal-type vacuole lumen
M	0004177	molecular_function	aminopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006457	biological_process	protein folding
M	0006508	biological_process	proteolysis
M	0006974	biological_process	DNA damage response
M	0008237	molecular_function	metallopeptidase activity
M	0008270	molecular_function	zinc ion binding
M	0008643	biological_process	carbohydrate transport
M	0015768	biological_process	maltose transport
M	0016020	cellular_component	membrane
M	0030288	cellular_component	outer membrane-bounded periplasmic space
M	0034219	biological_process	carbohydrate transmembrane transport
M	0034289	biological_process	detection of maltose stimulus
M	0042597	cellular_component	periplasmic space
M	0042956	biological_process	maltodextrin transmembrane transport
M	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
M	0046872	molecular_function	metal ion binding
M	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
M	0055085	biological_process	transmembrane transport
M	0060326	biological_process	cell chemotaxis
M	0070006	molecular_function	metalloaminopeptidase activity
M	1901982	molecular_function	maltose binding
M	1990060	cellular_component	maltose transport complex
O	0000324	cellular_component	fungal-type vacuole
O	0000328	cellular_component	fungal-type vacuole lumen
O	0004177	molecular_function	aminopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006457	biological_process	protein folding
O	0006508	biological_process	proteolysis
O	0006974	biological_process	DNA damage response
O	0008237	molecular_function	metallopeptidase activity
O	0008270	molecular_function	zinc ion binding
O	0008643	biological_process	carbohydrate transport
O	0015768	biological_process	maltose transport
O	0016020	cellular_component	membrane
O	0030288	cellular_component	outer membrane-bounded periplasmic space
O	0034219	biological_process	carbohydrate transmembrane transport
O	0034289	biological_process	detection of maltose stimulus
O	0042597	cellular_component	periplasmic space
O	0042956	biological_process	maltodextrin transmembrane transport
O	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
O	0046872	molecular_function	metal ion binding
O	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
O	0055085	biological_process	transmembrane transport
O	0060326	biological_process	cell chemotaxis
O	0070006	molecular_function	metalloaminopeptidase activity
O	1901982	molecular_function	maltose binding
O	1990060	cellular_component	maltose transport complex
Q	0000324	cellular_component	fungal-type vacuole
Q	0000328	cellular_component	fungal-type vacuole lumen
Q	0004177	molecular_function	aminopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006457	biological_process	protein folding
Q	0006508	biological_process	proteolysis
Q	0006974	biological_process	DNA damage response
Q	0008237	molecular_function	metallopeptidase activity
Q	0008270	molecular_function	zinc ion binding
Q	0008643	biological_process	carbohydrate transport
Q	0015768	biological_process	maltose transport
Q	0016020	cellular_component	membrane
Q	0030288	cellular_component	outer membrane-bounded periplasmic space
Q	0034219	biological_process	carbohydrate transmembrane transport
Q	0034289	biological_process	detection of maltose stimulus
Q	0042597	cellular_component	periplasmic space
Q	0042956	biological_process	maltodextrin transmembrane transport
Q	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
Q	0046872	molecular_function	metal ion binding
Q	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
Q	0055085	biological_process	transmembrane transport
Q	0060326	biological_process	cell chemotaxis
Q	0070006	molecular_function	metalloaminopeptidase activity
Q	1901982	molecular_function	maltose binding
Q	1990060	cellular_component	maltose transport complex
S	0000324	cellular_component	fungal-type vacuole
S	0000328	cellular_component	fungal-type vacuole lumen
S	0004177	molecular_function	aminopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006457	biological_process	protein folding
S	0006508	biological_process	proteolysis
S	0006974	biological_process	DNA damage response
S	0008237	molecular_function	metallopeptidase activity
S	0008270	molecular_function	zinc ion binding
S	0008643	biological_process	carbohydrate transport
S	0015768	biological_process	maltose transport
S	0016020	cellular_component	membrane
S	0030288	cellular_component	outer membrane-bounded periplasmic space
S	0034219	biological_process	carbohydrate transmembrane transport
S	0034289	biological_process	detection of maltose stimulus
S	0042597	cellular_component	periplasmic space
S	0042956	biological_process	maltodextrin transmembrane transport
S	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
S	0046872	molecular_function	metal ion binding
S	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
S	0055085	biological_process	transmembrane transport
S	0060326	biological_process	cell chemotaxis
S	0070006	molecular_function	metalloaminopeptidase activity
S	1901982	molecular_function	maltose binding
S	1990060	cellular_component	maltose transport complex
V	0000324	cellular_component	fungal-type vacuole
V	0000328	cellular_component	fungal-type vacuole lumen
V	0004177	molecular_function	aminopeptidase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006457	biological_process	protein folding
V	0006508	biological_process	proteolysis
V	0006974	biological_process	DNA damage response
V	0008237	molecular_function	metallopeptidase activity
V	0008270	molecular_function	zinc ion binding
V	0008643	biological_process	carbohydrate transport
V	0015768	biological_process	maltose transport
V	0016020	cellular_component	membrane
V	0030288	cellular_component	outer membrane-bounded periplasmic space
V	0034219	biological_process	carbohydrate transmembrane transport
V	0034289	biological_process	detection of maltose stimulus
V	0042597	cellular_component	periplasmic space
V	0042956	biological_process	maltodextrin transmembrane transport
V	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
V	0046872	molecular_function	metal ion binding
V	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
V	0055085	biological_process	transmembrane transport
V	0060326	biological_process	cell chemotaxis
V	0070006	molecular_function	metalloaminopeptidase activity
V	1901982	molecular_function	maltose binding
V	1990060	cellular_component	maltose transport complex
X	0000324	cellular_component	fungal-type vacuole
X	0000328	cellular_component	fungal-type vacuole lumen
X	0004177	molecular_function	aminopeptidase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006457	biological_process	protein folding
X	0006508	biological_process	proteolysis
X	0006974	biological_process	DNA damage response
X	0008237	molecular_function	metallopeptidase activity
X	0008270	molecular_function	zinc ion binding
X	0008643	biological_process	carbohydrate transport
X	0015768	biological_process	maltose transport
X	0016020	cellular_component	membrane
X	0030288	cellular_component	outer membrane-bounded periplasmic space
X	0034219	biological_process	carbohydrate transmembrane transport
X	0034289	biological_process	detection of maltose stimulus
X	0042597	cellular_component	periplasmic space
X	0042956	biological_process	maltodextrin transmembrane transport
X	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
X	0046872	molecular_function	metal ion binding
X	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
X	0055085	biological_process	transmembrane transport
X	0060326	biological_process	cell chemotaxis
X	0070006	molecular_function	metalloaminopeptidase activity
X	1901982	molecular_function	maltose binding
X	1990060	cellular_component	maltose transport complex

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO2133-ASN2150

site_id	PS01357
Number of Residues	27
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CntClkiirnd.SFhCtk...CfDFdVCrdC

Chain	Residue	Details
A	CYS1062-CYS1088

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS93
A	HIS437
S	HIS437
V	HIS93
V	HIS168
V	ASP262
V	GLU298
V	GLU299
V	ASP343
V	HIS346
V	LYS371
V	TYR378
C	HIS93
V	HIS437
X	HIS93
X	HIS168
X	ASP262
X	GLU298
X	GLU299
X	ASP343
X	HIS346
X	LYS371
X	TYR378
C	HIS168
X	HIS437
C	ASP262
C	GLU298
C	GLU299
C	ASP343
C	HIS346
C	LYS371
C	TYR378
A	HIS168
C	HIS437
E	HIS93
E	HIS168
E	ASP262
E	GLU298
E	GLU299
E	ASP343
E	HIS346
E	LYS371
E	TYR378
A	ASP262
E	HIS437
G	HIS93
G	HIS168
G	ASP262
G	GLU298
G	GLU299
G	ASP343
G	HIS346
G	LYS371
G	TYR378
A	GLU298
G	HIS437
I	HIS93
I	HIS168
I	ASP262
I	GLU298
I	GLU299
I	ASP343
I	HIS346
I	LYS371
I	TYR378
A	GLU299
I	HIS437
K	HIS93
K	HIS168
K	ASP262
K	GLU298
K	GLU299
K	ASP343
K	HIS346
K	LYS371
K	TYR378
A	ASP343
K	HIS437
M	HIS93
M	HIS168
M	ASP262
M	GLU298
M	GLU299
M	ASP343
M	HIS346
M	LYS371
M	TYR378
A	HIS346
M	HIS437
O	HIS93
O	HIS168
O	ASP262
O	GLU298
O	GLU299
O	ASP343
O	HIS346
O	LYS371
O	TYR378
A	LYS371
O	HIS437
Q	HIS93
Q	HIS168
Q	ASP262
Q	GLU298
Q	GLU299
Q	ASP343
Q	HIS346
Q	LYS371
Q	TYR378
A	TYR378
Q	HIS437
S	HIS93
S	HIS168
S	ASP262
S	GLU298
S	GLU299
S	ASP343
S	HIS346
S	LYS371
S	TYR378

site_id	SWS_FT_FI2
Number of Residues	660
Details	ZN_FING: ZZ-type 1 => ECO:0000255\|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	SER1057-SER1112
S	SER1057-SER1112
V	SER1057-SER1112
X	SER1057-SER1112
C	SER1057-SER1112
E	SER1057-SER1112
G	SER1057-SER1112
I	SER1057-SER1112
K	SER1057-SER1112
M	SER1057-SER1112
O	SER1057-SER1112
Q	SER1057-SER1112

site_id	SWS_FT_FI3
Number of Residues	96
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	CYS1062
C	CYS1065
C	CYS1076
C	CYS1079
C	CYS1085
C	CYS1088
C	HIS1096
C	HIS1102
E	CYS1062
E	CYS1065
E	CYS1076
A	CYS1065
E	CYS1079
E	CYS1085
E	CYS1088
E	HIS1096
E	HIS1102
G	CYS1062
G	CYS1065
G	CYS1076
G	CYS1079
G	CYS1085
A	CYS1076
G	CYS1088
G	HIS1096
G	HIS1102
I	CYS1062
I	CYS1065
I	CYS1076
I	CYS1079
I	CYS1085
I	CYS1088
I	HIS1096
A	CYS1079
I	HIS1102
K	CYS1062
K	CYS1065
K	CYS1076
K	CYS1079
K	CYS1085
K	CYS1088
K	HIS1096
K	HIS1102
M	CYS1062
A	CYS1085
M	CYS1065
M	CYS1076
M	CYS1079
M	CYS1085
M	CYS1088
M	HIS1096
M	HIS1102
O	CYS1062
O	CYS1065
O	CYS1076
A	CYS1088
O	CYS1079
O	CYS1085
O	CYS1088
O	HIS1096
O	HIS1102
Q	CYS1062
Q	CYS1065
Q	CYS1076
Q	CYS1079
Q	CYS1085
A	HIS1096
Q	CYS1088
Q	HIS1096
Q	HIS1102
S	CYS1062
S	CYS1065
S	CYS1076
S	CYS1079
S	CYS1085
S	CYS1088
S	HIS1096
A	HIS1102
S	HIS1102
V	CYS1062
V	CYS1065
V	CYS1076
V	CYS1079
V	CYS1085
V	CYS1088
V	HIS1096
V	HIS1102
X	CYS1062
C	CYS1062
X	CYS1065
X	CYS1076
X	CYS1079
X	CYS1085
X	CYS1088
X	HIS1096
X	HIS1102

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)