7DDE

Cryo-EM structure of the Ape4 and Nbr1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000324	cellular_component	fungal-type vacuole
A	0000328	cellular_component	fungal-type vacuole lumen
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005775	cellular_component	vacuolar lumen
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0006508	biological_process	proteolysis
A	0006974	biological_process	DNA damage response
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008643	biological_process	carbohydrate transport
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0046872	molecular_function	metal ion binding
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	0070006	molecular_function	metalloaminopeptidase activity
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
C	0000324	cellular_component	fungal-type vacuole
C	0000328	cellular_component	fungal-type vacuole lumen
C	0004177	molecular_function	aminopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005775	cellular_component	vacuolar lumen
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006508	biological_process	proteolysis
C	0006974	biological_process	DNA damage response
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0008643	biological_process	carbohydrate transport
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0046872	molecular_function	metal ion binding
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	0070006	molecular_function	metalloaminopeptidase activity
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
E	0000324	cellular_component	fungal-type vacuole
E	0000328	cellular_component	fungal-type vacuole lumen
E	0004177	molecular_function	aminopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005775	cellular_component	vacuolar lumen
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0006508	biological_process	proteolysis
E	0006974	biological_process	DNA damage response
E	0008233	molecular_function	peptidase activity
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0008643	biological_process	carbohydrate transport
E	0015768	biological_process	maltose transport
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0034219	biological_process	carbohydrate transmembrane transport
E	0034289	biological_process	detection of maltose stimulus
E	0042597	cellular_component	periplasmic space
E	0042956	biological_process	maltodextrin transmembrane transport
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0046872	molecular_function	metal ion binding
E	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
E	0055085	biological_process	transmembrane transport
E	0060326	biological_process	cell chemotaxis
E	0070006	molecular_function	metalloaminopeptidase activity
E	1901982	molecular_function	maltose binding
E	1990060	cellular_component	maltose transport complex
G	0000324	cellular_component	fungal-type vacuole
G	0000328	cellular_component	fungal-type vacuole lumen
G	0004177	molecular_function	aminopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005775	cellular_component	vacuolar lumen
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0006508	biological_process	proteolysis
G	0006974	biological_process	DNA damage response
G	0008233	molecular_function	peptidase activity
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0008643	biological_process	carbohydrate transport
G	0015768	biological_process	maltose transport
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0034219	biological_process	carbohydrate transmembrane transport
G	0034289	biological_process	detection of maltose stimulus
G	0042597	cellular_component	periplasmic space
G	0042956	biological_process	maltodextrin transmembrane transport
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0046872	molecular_function	metal ion binding
G	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
G	0055085	biological_process	transmembrane transport
G	0060326	biological_process	cell chemotaxis
G	0070006	molecular_function	metalloaminopeptidase activity
G	1901982	molecular_function	maltose binding
G	1990060	cellular_component	maltose transport complex
I	0000324	cellular_component	fungal-type vacuole
I	0000328	cellular_component	fungal-type vacuole lumen
I	0004177	molecular_function	aminopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005775	cellular_component	vacuolar lumen
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0006508	biological_process	proteolysis
I	0006974	biological_process	DNA damage response
I	0008233	molecular_function	peptidase activity
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0008643	biological_process	carbohydrate transport
I	0015768	biological_process	maltose transport
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0030288	cellular_component	outer membrane-bounded periplasmic space
I	0034219	biological_process	carbohydrate transmembrane transport
I	0034289	biological_process	detection of maltose stimulus
I	0042597	cellular_component	periplasmic space
I	0042956	biological_process	maltodextrin transmembrane transport
I	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
I	0046872	molecular_function	metal ion binding
I	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
I	0055085	biological_process	transmembrane transport
I	0060326	biological_process	cell chemotaxis
I	0070006	molecular_function	metalloaminopeptidase activity
I	1901982	molecular_function	maltose binding
I	1990060	cellular_component	maltose transport complex
K	0000324	cellular_component	fungal-type vacuole
K	0000328	cellular_component	fungal-type vacuole lumen
K	0004177	molecular_function	aminopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005775	cellular_component	vacuolar lumen
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0006508	biological_process	proteolysis
K	0006974	biological_process	DNA damage response
K	0008233	molecular_function	peptidase activity
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0008643	biological_process	carbohydrate transport
K	0015768	biological_process	maltose transport
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0030288	cellular_component	outer membrane-bounded periplasmic space
K	0034219	biological_process	carbohydrate transmembrane transport
K	0034289	biological_process	detection of maltose stimulus
K	0042597	cellular_component	periplasmic space
K	0042956	biological_process	maltodextrin transmembrane transport
K	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
K	0046872	molecular_function	metal ion binding
K	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
K	0055085	biological_process	transmembrane transport
K	0060326	biological_process	cell chemotaxis
K	0070006	molecular_function	metalloaminopeptidase activity
K	1901982	molecular_function	maltose binding
K	1990060	cellular_component	maltose transport complex
M	0000324	cellular_component	fungal-type vacuole
M	0000328	cellular_component	fungal-type vacuole lumen
M	0004177	molecular_function	aminopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005775	cellular_component	vacuolar lumen
M	0005829	cellular_component	cytosol
M	0006457	biological_process	protein folding
M	0006508	biological_process	proteolysis
M	0006974	biological_process	DNA damage response
M	0008233	molecular_function	peptidase activity
M	0008237	molecular_function	metallopeptidase activity
M	0008270	molecular_function	zinc ion binding
M	0008643	biological_process	carbohydrate transport
M	0015768	biological_process	maltose transport
M	0016020	cellular_component	membrane
M	0016787	molecular_function	hydrolase activity
M	0030288	cellular_component	outer membrane-bounded periplasmic space
M	0034219	biological_process	carbohydrate transmembrane transport
M	0034289	biological_process	detection of maltose stimulus
M	0042597	cellular_component	periplasmic space
M	0042956	biological_process	maltodextrin transmembrane transport
M	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
M	0046872	molecular_function	metal ion binding
M	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
M	0055085	biological_process	transmembrane transport
M	0060326	biological_process	cell chemotaxis
M	0070006	molecular_function	metalloaminopeptidase activity
M	1901982	molecular_function	maltose binding
M	1990060	cellular_component	maltose transport complex
O	0000324	cellular_component	fungal-type vacuole
O	0000328	cellular_component	fungal-type vacuole lumen
O	0004177	molecular_function	aminopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005775	cellular_component	vacuolar lumen
O	0005829	cellular_component	cytosol
O	0006457	biological_process	protein folding
O	0006508	biological_process	proteolysis
O	0006974	biological_process	DNA damage response
O	0008233	molecular_function	peptidase activity
O	0008237	molecular_function	metallopeptidase activity
O	0008270	molecular_function	zinc ion binding
O	0008643	biological_process	carbohydrate transport
O	0015768	biological_process	maltose transport
O	0016020	cellular_component	membrane
O	0016787	molecular_function	hydrolase activity
O	0030288	cellular_component	outer membrane-bounded periplasmic space
O	0034219	biological_process	carbohydrate transmembrane transport
O	0034289	biological_process	detection of maltose stimulus
O	0042597	cellular_component	periplasmic space
O	0042956	biological_process	maltodextrin transmembrane transport
O	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
O	0046872	molecular_function	metal ion binding
O	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
O	0055085	biological_process	transmembrane transport
O	0060326	biological_process	cell chemotaxis
O	0070006	molecular_function	metalloaminopeptidase activity
O	1901982	molecular_function	maltose binding
O	1990060	cellular_component	maltose transport complex
Q	0000324	cellular_component	fungal-type vacuole
Q	0000328	cellular_component	fungal-type vacuole lumen
Q	0004177	molecular_function	aminopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005775	cellular_component	vacuolar lumen
Q	0005829	cellular_component	cytosol
Q	0006457	biological_process	protein folding
Q	0006508	biological_process	proteolysis
Q	0006974	biological_process	DNA damage response
Q	0008233	molecular_function	peptidase activity
Q	0008237	molecular_function	metallopeptidase activity
Q	0008270	molecular_function	zinc ion binding
Q	0008643	biological_process	carbohydrate transport
Q	0015768	biological_process	maltose transport
Q	0016020	cellular_component	membrane
Q	0016787	molecular_function	hydrolase activity
Q	0030288	cellular_component	outer membrane-bounded periplasmic space
Q	0034219	biological_process	carbohydrate transmembrane transport
Q	0034289	biological_process	detection of maltose stimulus
Q	0042597	cellular_component	periplasmic space
Q	0042956	biological_process	maltodextrin transmembrane transport
Q	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
Q	0046872	molecular_function	metal ion binding
Q	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
Q	0055085	biological_process	transmembrane transport
Q	0060326	biological_process	cell chemotaxis
Q	0070006	molecular_function	metalloaminopeptidase activity
Q	1901982	molecular_function	maltose binding
Q	1990060	cellular_component	maltose transport complex
S	0000324	cellular_component	fungal-type vacuole
S	0000328	cellular_component	fungal-type vacuole lumen
S	0004177	molecular_function	aminopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005775	cellular_component	vacuolar lumen
S	0005829	cellular_component	cytosol
S	0006457	biological_process	protein folding
S	0006508	biological_process	proteolysis
S	0006974	biological_process	DNA damage response
S	0008233	molecular_function	peptidase activity
S	0008237	molecular_function	metallopeptidase activity
S	0008270	molecular_function	zinc ion binding
S	0008643	biological_process	carbohydrate transport
S	0015768	biological_process	maltose transport
S	0016020	cellular_component	membrane
S	0016787	molecular_function	hydrolase activity
S	0030288	cellular_component	outer membrane-bounded periplasmic space
S	0034219	biological_process	carbohydrate transmembrane transport
S	0034289	biological_process	detection of maltose stimulus
S	0042597	cellular_component	periplasmic space
S	0042956	biological_process	maltodextrin transmembrane transport
S	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
S	0046872	molecular_function	metal ion binding
S	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
S	0055085	biological_process	transmembrane transport
S	0060326	biological_process	cell chemotaxis
S	0070006	molecular_function	metalloaminopeptidase activity
S	1901982	molecular_function	maltose binding
S	1990060	cellular_component	maltose transport complex
V	0000324	cellular_component	fungal-type vacuole
V	0000328	cellular_component	fungal-type vacuole lumen
V	0004177	molecular_function	aminopeptidase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005775	cellular_component	vacuolar lumen
V	0005829	cellular_component	cytosol
V	0006457	biological_process	protein folding
V	0006508	biological_process	proteolysis
V	0006974	biological_process	DNA damage response
V	0008233	molecular_function	peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008270	molecular_function	zinc ion binding
V	0008643	biological_process	carbohydrate transport
V	0015768	biological_process	maltose transport
V	0016020	cellular_component	membrane
V	0016787	molecular_function	hydrolase activity
V	0030288	cellular_component	outer membrane-bounded periplasmic space
V	0034219	biological_process	carbohydrate transmembrane transport
V	0034289	biological_process	detection of maltose stimulus
V	0042597	cellular_component	periplasmic space
V	0042956	biological_process	maltodextrin transmembrane transport
V	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
V	0046872	molecular_function	metal ion binding
V	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
V	0055085	biological_process	transmembrane transport
V	0060326	biological_process	cell chemotaxis
V	0070006	molecular_function	metalloaminopeptidase activity
V	1901982	molecular_function	maltose binding
V	1990060	cellular_component	maltose transport complex
X	0000324	cellular_component	fungal-type vacuole
X	0000328	cellular_component	fungal-type vacuole lumen
X	0004177	molecular_function	aminopeptidase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005775	cellular_component	vacuolar lumen
X	0005829	cellular_component	cytosol
X	0006457	biological_process	protein folding
X	0006508	biological_process	proteolysis
X	0006974	biological_process	DNA damage response
X	0008233	molecular_function	peptidase activity
X	0008237	molecular_function	metallopeptidase activity
X	0008270	molecular_function	zinc ion binding
X	0008643	biological_process	carbohydrate transport
X	0015768	biological_process	maltose transport
X	0016020	cellular_component	membrane
X	0016787	molecular_function	hydrolase activity
X	0030288	cellular_component	outer membrane-bounded periplasmic space
X	0034219	biological_process	carbohydrate transmembrane transport
X	0034289	biological_process	detection of maltose stimulus
X	0042597	cellular_component	periplasmic space
X	0042956	biological_process	maltodextrin transmembrane transport
X	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
X	0046872	molecular_function	metal ion binding
X	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
X	0055085	biological_process	transmembrane transport
X	0060326	biological_process	cell chemotaxis
X	0070006	molecular_function	metalloaminopeptidase activity
X	1901982	molecular_function	maltose binding
X	1990060	cellular_component	maltose transport complex

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO2133-ASN2150

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site_id	PS01357
Number of Residues	27
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CntClkiirnd.SFhCtk...CfDFdVCrdC

Chain	Residue	Details
A	CYS1062-CYS1088

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34169534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9ULA0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34169534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DD9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DDE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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