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7DDE

Cryo-EM structure of the Ape4 and Nbr1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000324cellular_componentfungal-type vacuole
A0000328cellular_componentfungal-type vacuole lumen
A0004177molecular_functionaminopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005773cellular_componentvacuole
A0005775cellular_componentvacuolar lumen
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006508biological_processproteolysis
A0006974biological_processDNA damage response
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0008643biological_processcarbohydrate transport
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0030288cellular_componentouter membrane-bounded periplasmic space
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0042597cellular_componentperiplasmic space
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0046872molecular_functionmetal ion binding
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0070006molecular_functionmetalloaminopeptidase activity
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
C0000324cellular_componentfungal-type vacuole
C0000328cellular_componentfungal-type vacuole lumen
C0004177molecular_functionaminopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005773cellular_componentvacuole
C0005775cellular_componentvacuolar lumen
C0005829cellular_componentcytosol
C0006457biological_processprotein folding
C0006508biological_processproteolysis
C0006974biological_processDNA damage response
C0008233molecular_functionpeptidase activity
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0008643biological_processcarbohydrate transport
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0030288cellular_componentouter membrane-bounded periplasmic space
C0034219biological_processcarbohydrate transmembrane transport
C0034289biological_processdetection of maltose stimulus
C0042597cellular_componentperiplasmic space
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0046872molecular_functionmetal ion binding
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0060326biological_processcell chemotaxis
C0070006molecular_functionmetalloaminopeptidase activity
C1901982molecular_functionmaltose binding
C1990060cellular_componentmaltose transport complex
E0000324cellular_componentfungal-type vacuole
E0000328cellular_componentfungal-type vacuole lumen
E0004177molecular_functionaminopeptidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005773cellular_componentvacuole
E0005775cellular_componentvacuolar lumen
E0005829cellular_componentcytosol
E0006457biological_processprotein folding
E0006508biological_processproteolysis
E0006974biological_processDNA damage response
E0008233molecular_functionpeptidase activity
E0008237molecular_functionmetallopeptidase activity
E0008270molecular_functionzinc ion binding
E0008643biological_processcarbohydrate transport
E0015768biological_processmaltose transport
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0030288cellular_componentouter membrane-bounded periplasmic space
E0034219biological_processcarbohydrate transmembrane transport
E0034289biological_processdetection of maltose stimulus
E0042597cellular_componentperiplasmic space
E0042956biological_processmaltodextrin transmembrane transport
E0043190cellular_componentATP-binding cassette (ABC) transporter complex
E0046872molecular_functionmetal ion binding
E0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
E0055085biological_processtransmembrane transport
E0060326biological_processcell chemotaxis
E0070006molecular_functionmetalloaminopeptidase activity
E1901982molecular_functionmaltose binding
E1990060cellular_componentmaltose transport complex
G0000324cellular_componentfungal-type vacuole
G0000328cellular_componentfungal-type vacuole lumen
G0004177molecular_functionaminopeptidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005773cellular_componentvacuole
G0005775cellular_componentvacuolar lumen
G0005829cellular_componentcytosol
G0006457biological_processprotein folding
G0006508biological_processproteolysis
G0006974biological_processDNA damage response
G0008233molecular_functionpeptidase activity
G0008237molecular_functionmetallopeptidase activity
G0008270molecular_functionzinc ion binding
G0008643biological_processcarbohydrate transport
G0015768biological_processmaltose transport
G0016020cellular_componentmembrane
G0016787molecular_functionhydrolase activity
G0030288cellular_componentouter membrane-bounded periplasmic space
G0034219biological_processcarbohydrate transmembrane transport
G0034289biological_processdetection of maltose stimulus
G0042597cellular_componentperiplasmic space
G0042956biological_processmaltodextrin transmembrane transport
G0043190cellular_componentATP-binding cassette (ABC) transporter complex
G0046872molecular_functionmetal ion binding
G0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
G0055085biological_processtransmembrane transport
G0060326biological_processcell chemotaxis
G0070006molecular_functionmetalloaminopeptidase activity
G1901982molecular_functionmaltose binding
G1990060cellular_componentmaltose transport complex
I0000324cellular_componentfungal-type vacuole
I0000328cellular_componentfungal-type vacuole lumen
I0004177molecular_functionaminopeptidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005773cellular_componentvacuole
I0005775cellular_componentvacuolar lumen
I0005829cellular_componentcytosol
I0006457biological_processprotein folding
I0006508biological_processproteolysis
I0006974biological_processDNA damage response
I0008233molecular_functionpeptidase activity
I0008237molecular_functionmetallopeptidase activity
I0008270molecular_functionzinc ion binding
I0008643biological_processcarbohydrate transport
I0015768biological_processmaltose transport
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0030288cellular_componentouter membrane-bounded periplasmic space
I0034219biological_processcarbohydrate transmembrane transport
I0034289biological_processdetection of maltose stimulus
I0042597cellular_componentperiplasmic space
I0042956biological_processmaltodextrin transmembrane transport
I0043190cellular_componentATP-binding cassette (ABC) transporter complex
I0046872molecular_functionmetal ion binding
I0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
I0055085biological_processtransmembrane transport
I0060326biological_processcell chemotaxis
I0070006molecular_functionmetalloaminopeptidase activity
I1901982molecular_functionmaltose binding
I1990060cellular_componentmaltose transport complex
K0000324cellular_componentfungal-type vacuole
K0000328cellular_componentfungal-type vacuole lumen
K0004177molecular_functionaminopeptidase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005773cellular_componentvacuole
K0005775cellular_componentvacuolar lumen
K0005829cellular_componentcytosol
K0006457biological_processprotein folding
K0006508biological_processproteolysis
K0006974biological_processDNA damage response
K0008233molecular_functionpeptidase activity
K0008237molecular_functionmetallopeptidase activity
K0008270molecular_functionzinc ion binding
K0008643biological_processcarbohydrate transport
K0015768biological_processmaltose transport
K0016020cellular_componentmembrane
K0016787molecular_functionhydrolase activity
K0030288cellular_componentouter membrane-bounded periplasmic space
K0034219biological_processcarbohydrate transmembrane transport
K0034289biological_processdetection of maltose stimulus
K0042597cellular_componentperiplasmic space
K0042956biological_processmaltodextrin transmembrane transport
K0043190cellular_componentATP-binding cassette (ABC) transporter complex
K0046872molecular_functionmetal ion binding
K0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
K0055085biological_processtransmembrane transport
K0060326biological_processcell chemotaxis
K0070006molecular_functionmetalloaminopeptidase activity
K1901982molecular_functionmaltose binding
K1990060cellular_componentmaltose transport complex
M0000324cellular_componentfungal-type vacuole
M0000328cellular_componentfungal-type vacuole lumen
M0004177molecular_functionaminopeptidase activity
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005773cellular_componentvacuole
M0005775cellular_componentvacuolar lumen
M0005829cellular_componentcytosol
M0006457biological_processprotein folding
M0006508biological_processproteolysis
M0006974biological_processDNA damage response
M0008233molecular_functionpeptidase activity
M0008237molecular_functionmetallopeptidase activity
M0008270molecular_functionzinc ion binding
M0008643biological_processcarbohydrate transport
M0015768biological_processmaltose transport
M0016020cellular_componentmembrane
M0016787molecular_functionhydrolase activity
M0030288cellular_componentouter membrane-bounded periplasmic space
M0034219biological_processcarbohydrate transmembrane transport
M0034289biological_processdetection of maltose stimulus
M0042597cellular_componentperiplasmic space
M0042956biological_processmaltodextrin transmembrane transport
M0043190cellular_componentATP-binding cassette (ABC) transporter complex
M0046872molecular_functionmetal ion binding
M0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
M0055085biological_processtransmembrane transport
M0060326biological_processcell chemotaxis
M0070006molecular_functionmetalloaminopeptidase activity
M1901982molecular_functionmaltose binding
M1990060cellular_componentmaltose transport complex
O0000324cellular_componentfungal-type vacuole
O0000328cellular_componentfungal-type vacuole lumen
O0004177molecular_functionaminopeptidase activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005773cellular_componentvacuole
O0005775cellular_componentvacuolar lumen
O0005829cellular_componentcytosol
O0006457biological_processprotein folding
O0006508biological_processproteolysis
O0006974biological_processDNA damage response
O0008233molecular_functionpeptidase activity
O0008237molecular_functionmetallopeptidase activity
O0008270molecular_functionzinc ion binding
O0008643biological_processcarbohydrate transport
O0015768biological_processmaltose transport
O0016020cellular_componentmembrane
O0016787molecular_functionhydrolase activity
O0030288cellular_componentouter membrane-bounded periplasmic space
O0034219biological_processcarbohydrate transmembrane transport
O0034289biological_processdetection of maltose stimulus
O0042597cellular_componentperiplasmic space
O0042956biological_processmaltodextrin transmembrane transport
O0043190cellular_componentATP-binding cassette (ABC) transporter complex
O0046872molecular_functionmetal ion binding
O0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
O0055085biological_processtransmembrane transport
O0060326biological_processcell chemotaxis
O0070006molecular_functionmetalloaminopeptidase activity
O1901982molecular_functionmaltose binding
O1990060cellular_componentmaltose transport complex
Q0000324cellular_componentfungal-type vacuole
Q0000328cellular_componentfungal-type vacuole lumen
Q0004177molecular_functionaminopeptidase activity
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005773cellular_componentvacuole
Q0005775cellular_componentvacuolar lumen
Q0005829cellular_componentcytosol
Q0006457biological_processprotein folding
Q0006508biological_processproteolysis
Q0006974biological_processDNA damage response
Q0008233molecular_functionpeptidase activity
Q0008237molecular_functionmetallopeptidase activity
Q0008270molecular_functionzinc ion binding
Q0008643biological_processcarbohydrate transport
Q0015768biological_processmaltose transport
Q0016020cellular_componentmembrane
Q0016787molecular_functionhydrolase activity
Q0030288cellular_componentouter membrane-bounded periplasmic space
Q0034219biological_processcarbohydrate transmembrane transport
Q0034289biological_processdetection of maltose stimulus
Q0042597cellular_componentperiplasmic space
Q0042956biological_processmaltodextrin transmembrane transport
Q0043190cellular_componentATP-binding cassette (ABC) transporter complex
Q0046872molecular_functionmetal ion binding
Q0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
Q0055085biological_processtransmembrane transport
Q0060326biological_processcell chemotaxis
Q0070006molecular_functionmetalloaminopeptidase activity
Q1901982molecular_functionmaltose binding
Q1990060cellular_componentmaltose transport complex
S0000324cellular_componentfungal-type vacuole
S0000328cellular_componentfungal-type vacuole lumen
S0004177molecular_functionaminopeptidase activity
S0005515molecular_functionprotein binding
S0005737cellular_componentcytoplasm
S0005773cellular_componentvacuole
S0005775cellular_componentvacuolar lumen
S0005829cellular_componentcytosol
S0006457biological_processprotein folding
S0006508biological_processproteolysis
S0006974biological_processDNA damage response
S0008233molecular_functionpeptidase activity
S0008237molecular_functionmetallopeptidase activity
S0008270molecular_functionzinc ion binding
S0008643biological_processcarbohydrate transport
S0015768biological_processmaltose transport
S0016020cellular_componentmembrane
S0016787molecular_functionhydrolase activity
S0030288cellular_componentouter membrane-bounded periplasmic space
S0034219biological_processcarbohydrate transmembrane transport
S0034289biological_processdetection of maltose stimulus
S0042597cellular_componentperiplasmic space
S0042956biological_processmaltodextrin transmembrane transport
S0043190cellular_componentATP-binding cassette (ABC) transporter complex
S0046872molecular_functionmetal ion binding
S0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
S0055085biological_processtransmembrane transport
S0060326biological_processcell chemotaxis
S0070006molecular_functionmetalloaminopeptidase activity
S1901982molecular_functionmaltose binding
S1990060cellular_componentmaltose transport complex
V0000324cellular_componentfungal-type vacuole
V0000328cellular_componentfungal-type vacuole lumen
V0004177molecular_functionaminopeptidase activity
V0005515molecular_functionprotein binding
V0005737cellular_componentcytoplasm
V0005773cellular_componentvacuole
V0005775cellular_componentvacuolar lumen
V0005829cellular_componentcytosol
V0006457biological_processprotein folding
V0006508biological_processproteolysis
V0006974biological_processDNA damage response
V0008233molecular_functionpeptidase activity
V0008237molecular_functionmetallopeptidase activity
V0008270molecular_functionzinc ion binding
V0008643biological_processcarbohydrate transport
V0015768biological_processmaltose transport
V0016020cellular_componentmembrane
V0016787molecular_functionhydrolase activity
V0030288cellular_componentouter membrane-bounded periplasmic space
V0034219biological_processcarbohydrate transmembrane transport
V0034289biological_processdetection of maltose stimulus
V0042597cellular_componentperiplasmic space
V0042956biological_processmaltodextrin transmembrane transport
V0043190cellular_componentATP-binding cassette (ABC) transporter complex
V0046872molecular_functionmetal ion binding
V0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
V0055085biological_processtransmembrane transport
V0060326biological_processcell chemotaxis
V0070006molecular_functionmetalloaminopeptidase activity
V1901982molecular_functionmaltose binding
V1990060cellular_componentmaltose transport complex
X0000324cellular_componentfungal-type vacuole
X0000328cellular_componentfungal-type vacuole lumen
X0004177molecular_functionaminopeptidase activity
X0005515molecular_functionprotein binding
X0005737cellular_componentcytoplasm
X0005773cellular_componentvacuole
X0005775cellular_componentvacuolar lumen
X0005829cellular_componentcytosol
X0006457biological_processprotein folding
X0006508biological_processproteolysis
X0006974biological_processDNA damage response
X0008233molecular_functionpeptidase activity
X0008237molecular_functionmetallopeptidase activity
X0008270molecular_functionzinc ion binding
X0008643biological_processcarbohydrate transport
X0015768biological_processmaltose transport
X0016020cellular_componentmembrane
X0016787molecular_functionhydrolase activity
X0030288cellular_componentouter membrane-bounded periplasmic space
X0034219biological_processcarbohydrate transmembrane transport
X0034289biological_processdetection of maltose stimulus
X0042597cellular_componentperiplasmic space
X0042956biological_processmaltodextrin transmembrane transport
X0043190cellular_componentATP-binding cassette (ABC) transporter complex
X0046872molecular_functionmetal ion binding
X0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
X0055085biological_processtransmembrane transport
X0060326biological_processcell chemotaxis
X0070006molecular_functionmetalloaminopeptidase activity
X1901982molecular_functionmaltose binding
X1990060cellular_componentmaltose transport complex
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO2133-ASN2150

site_idPS01357
Number of Residues27
DetailsZF_ZZ_1 Zinc finger ZZ-type signature. CntClkiirnd.SFhCtk...CfDFdVCrdC
ChainResidueDetails
ACYS1062-CYS1088

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsBINDING: BINDING => ECO:0000269|PubMed:34169534, ECO:0007744|PDB:7DDE
ChainResidueDetails
ALEU99
CALA305
CHIS349
CCYS443
ELEU99
EPHE268
ESER304
EALA305
EHIS349
ECYS443
GLEU99
APHE268
GPHE268
GSER304
GALA305
GHIS349
GCYS443
ILEU99
IPHE268
ISER304
IALA305
IHIS349
ASER304
ICYS443
KLEU99
KPHE268
KSER304
KALA305
KHIS349
KCYS443
MLEU99
MPHE268
MSER304
AALA305
MALA305
MHIS349
MCYS443
OLEU99
OPHE268
OSER304
OALA305
OHIS349
OCYS443
QLEU99
AHIS349
QPHE268
QSER304
QALA305
QHIS349
QCYS443
SLEU99
SPHE268
SSER304
SALA305
SHIS349
ACYS443
SCYS443
VLEU99
VPHE268
VSER304
VALA305
VHIS349
VCYS443
XLEU99
XPHE268
XSER304
CLEU99
XALA305
XHIS349
XCYS443
CPHE268
CSER304

site_idSWS_FT_FI2
Number of Residues48
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9ULA0
ChainResidueDetails
AASN174
ETYR352
EARG377
EGLY384
GASN174
GTYR352
GARG377
GGLY384
IASN174
ITYR352
IARG377
ATYR352
IGLY384
KASN174
KTYR352
KARG377
KGLY384
MASN174
MTYR352
MARG377
MGLY384
OASN174
AARG377
OTYR352
OARG377
OGLY384
QASN174
QTYR352
QARG377
QGLY384
SASN174
STYR352
SARG377
AGLY384
SGLY384
VASN174
VTYR352
VARG377
VGLY384
XASN174
XTYR352
XARG377
XGLY384
CASN174
CTYR352
CARG377
CGLY384
EASN174

site_idSWS_FT_FI3
Number of Residues660
DetailsZN_FING: ZZ-type 1 => ECO:0000255|PROSITE-ProRule:PRU00228
ChainResidueDetails
ASER1057-SER1112
SSER1057-SER1112
VSER1057-SER1112
XSER1057-SER1112
CSER1057-SER1112
ESER1057-SER1112
GSER1057-SER1112
ISER1057-SER1112
KSER1057-SER1112
MSER1057-SER1112
OSER1057-SER1112
QSER1057-SER1112

site_idSWS_FT_FI4
Number of Residues96
DetailsBINDING: BINDING => ECO:0000269|PubMed:34169534, ECO:0007744|PDB:7DD9, ECO:0007744|PDB:7DDE
ChainResidueDetails
ACYS1062
CCYS1065
CCYS1076
CCYS1079
CCYS1085
CCYS1088
CHIS1096
CHIS1102
ECYS1062
ECYS1065
ECYS1076
ACYS1065
ECYS1079
ECYS1085
ECYS1088
EHIS1096
EHIS1102
GCYS1062
GCYS1065
GCYS1076
GCYS1079
GCYS1085
ACYS1076
GCYS1088
GHIS1096
GHIS1102
ICYS1062
ICYS1065
ICYS1076
ICYS1079
ICYS1085
ICYS1088
IHIS1096
ACYS1079
IHIS1102
KCYS1062
KCYS1065
KCYS1076
KCYS1079
KCYS1085
KCYS1088
KHIS1096
KHIS1102
MCYS1062
ACYS1085
MCYS1065
MCYS1076
MCYS1079
MCYS1085
MCYS1088
MHIS1096
MHIS1102
OCYS1062
OCYS1065
OCYS1076
ACYS1088
OCYS1079
OCYS1085
OCYS1088
OHIS1096
OHIS1102
QCYS1062
QCYS1065
QCYS1076
QCYS1079
QCYS1085
AHIS1096
QCYS1088
QHIS1096
QHIS1102
SCYS1062
SCYS1065
SCYS1076
SCYS1079
SCYS1085
SCYS1088
SHIS1096
AHIS1102
SHIS1102
VCYS1062
VCYS1065
VCYS1076
VCYS1079
VCYS1085
VCYS1088
VHIS1096
VHIS1102
XCYS1062
CCYS1062
XCYS1065
XCYS1076
XCYS1079
XCYS1085
XCYS1088
XHIS1096
XHIS1102

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PDB entries from 2025-06-18

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