7DD3

Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2

Functional Information from GO Data

Chain	GOid	namespace	contents
x	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
x	0003676	molecular_function	nucleic acid binding
x	0003723	molecular_function	RNA binding
x	0003724	molecular_function	RNA helicase activity
x	0004386	molecular_function	helicase activity
x	0005524	molecular_function	ATP binding
x	0005634	cellular_component	nucleus
x	0006396	biological_process	RNA processing
x	0006397	biological_process	mRNA processing
x	0008186	molecular_function	ATP-dependent activity, acting on RNA
x	0008380	biological_process	RNA splicing
x	0016787	molecular_function	hydrolase activity
x	0016887	molecular_function	ATP hydrolysis activity
x	0022613	biological_process	ribonucleoprotein complex biogenesis
x	0034247	biological_process	snoRNA splicing
x	0071006	cellular_component	U2-type catalytic step 1 spliceosome
x	1990904	cellular_component	ribonucleoprotein complex
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0001671	molecular_function	ATPase activator activity
y	0003676	molecular_function	nucleic acid binding
y	0005634	cellular_component	nucleus
y	0005681	cellular_component	spliceosomal complex
y	0005737	cellular_component	cytoplasm
y	0006397	biological_process	mRNA processing
y	0008380	biological_process	RNA splicing

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIMIDEAHE

Chain	Residue	Details
x	SER341-GLU350

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
x	GLY246

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
x	SER2

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