7CXR
Cryo-EM structure of human TMEM120A/TACAN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005637 | cellular_component | nuclear inner membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045087 | biological_process | innate immune response |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0051291 | biological_process | protein heterooligomerization |
| A | 0120225 | molecular_function | coenzyme A binding |
| A | 0140374 | biological_process | antiviral innate immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005637 | cellular_component | nuclear inner membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0008218 | biological_process | bioluminescence |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045087 | biological_process | innate immune response |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0051291 | biological_process | protein heterooligomerization |
| B | 0120225 | molecular_function | coenzyme A binding |
| B | 0140374 | biological_process | antiviral innate immune response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34409941","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7F3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34374645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7N7P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8C1E7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
