7CXR
Cryo-EM structure of human TMEM120A/TACAN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002376 | biological_process | immune system process |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005637 | cellular_component | nuclear inner membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0045087 | biological_process | innate immune response |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0051291 | biological_process | protein heterooligomerization |
| A | 0120225 | molecular_function | coenzyme A binding |
| A | 0140374 | biological_process | antiviral innate immune response |
| B | 0002376 | biological_process | immune system process |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005637 | cellular_component | nuclear inner membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0008218 | biological_process | bioluminescence |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0045087 | biological_process | innate immune response |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0051291 | biological_process | protein heterooligomerization |
| B | 0120225 | molecular_function | coenzyme A binding |
| B | 0140374 | biological_process | antiviral innate immune response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-GLU132 | |
| A | ARG178-LYS190 | |
| A | GLN241-ARG270 | |
| A | HIS331-ASP343 | |
| B | MET1-GLU132 | |
| B | ARG178-LYS190 | |
| B | GLN241-ARG270 | |
| B | HIS331-ASP343 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | TYR133-ARG152 | |
| B | TYR133-ARG152 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE153-ARG158 | |
| A | TRP210-LYS218 | |
| A | ASN295-GLU304 | |
| B | PHE153-ARG158 | |
| B | TRP210-LYS218 | |
| B | ASN295-GLU304 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | VAL159-ILE177 | |
| B | VAL159-ILE177 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | GLY191-THR209 | |
| B | GLY191-THR209 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | PHE219-TYR240 | |
| B | PHE219-TYR240 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | GLY271-PHE294 | |
| B | GLY271-PHE294 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P |
| Chain | Residue | Details |
| A | TRP305-HIS330 | |
| B | TRP305-HIS330 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34374645, ECO:0000269|PubMed:34409941, ECO:0007744|PDB:7F3T, ECO:0007744|PDB:7N7P |
| Chain | Residue | Details |
| A | LYS130 | |
| A | GLN237 | |
| A | TYR240 | |
| B | LYS130 | |
| B | GLN237 | |
| B | TYR240 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34374645, ECO:0007744|PDB:7N7P |
| Chain | Residue | Details |
| A | SER187 | |
| A | ARG188 | |
| A | GLN241 | |
| A | LYS332 | |
| B | SER187 | |
| B | ARG188 | |
| B | GLN241 | |
| B | LYS332 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8C1E7 |
| Chain | Residue | Details |
| A | HIS283 | |
| B | HIS283 |
