7CCZ
Crystal structure of the ES2 intermediate form of human hydroxymethylbilane synthase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
| B | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| B | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| B | 0006783 | biological_process | heme biosynthetic process |
| B | 0006784 | biological_process | heme A biosynthetic process |
| B | 0006785 | biological_process | heme B biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| B | 0033014 | biological_process | tetrapyrrole biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue 7J8 A 401 |
| Chain | Residue |
| A | SER96 |
| A | ARG150 |
| A | ARG173 |
| A | LEU188 |
| A | ALA189 |
| A | ARG195 |
| A | ALA214 |
| A | VAL215 |
| A | GLN217 |
| A | GLY218 |
| A | LEU254 |
| A | LYS98 |
| A | CYS261 |
| A | SER262 |
| A | HOH503 |
| A | HOH504 |
| A | HOH524 |
| A | HOH530 |
| A | HOH548 |
| A | HOH559 |
| A | HOH577 |
| A | HOH578 |
| A | ASP99 |
| A | HOH593 |
| A | HOH607 |
| A | HOH644 |
| A | LEU100 |
| A | PRO101 |
| A | THR102 |
| A | SER146 |
| A | SER147 |
| A | ARG149 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | binding site for Di-peptide 7J8 B 401 and CYS B 261 |
| Chain | Residue |
| B | SER96 |
| B | LYS98 |
| B | ASP99 |
| B | LEU100 |
| B | PRO101 |
| B | THR102 |
| B | SER146 |
| B | SER147 |
| B | ARG149 |
| B | ARG150 |
| B | ARG173 |
| B | LEU188 |
| B | ALA189 |
| B | ARG195 |
| B | VAL215 |
| B | GLN217 |
| B | GLY218 |
| B | LEU254 |
| B | GLY260 |
| B | SER262 |
| B | VAL263 |
| B | HOH505 |
| B | HOH510 |
| B | HOH516 |
| B | HOH518 |
| B | HOH538 |
| B | HOH547 |
| B | HOH554 |
| B | HOH582 |
| B | HOH592 |
| B | HOH598 |
| B | HOH628 |
Functional Information from PROSITE/UniProt
| site_id | PS00533 |
| Number of Residues | 17 |
| Details | PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaFlrhLeGGCsVPVA |
| Chain | Residue | Details |
| A | GLU250-ALA266 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P22907","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine","evidences":[{"source":"PubMed","id":"18936296","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
