7C61
Crystal structure of 5-HT1B-BRIL and SRP2070_Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCVIALDRYWaI |
| Chain | Residue | Details |
| A | ALA135-ILE151 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | PRO47-ALA72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 51 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | THR73-TYR86 | |
| A | ASP146-ARG165 | |
| A | MET411-SER430 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | LEU87-VAL111 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | THR112-GLN119 | |
| A | PHE185-HIS205 | |
| A | PRO378-HIS387 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | VAL120-LEU145 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | ALA166-PRO184 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | ILE206-GLY229 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | LEU356-MET377 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79 |
| Chain | Residue | Details |
| A | LEU388-THR410 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23519210, ECO:0007744|PDB:4IAR |
| Chain | Residue | Details |
| A | ASP129 | |
| A | THR134 | |
| A | VAL201 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Important for species-specific agonist sensitivity => ECO:0000269|PubMed:23519210 |
| Chain | Residue | Details |
| A | THR395 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| A | CYS428 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP246 | |
| A | ILE341 |
